Developmental Research Program

为了促进乳腺癌的优秀翻译研究，发展研究计划 (DRP)是该乳孢子的一个主要焦点。试点项目的支持使早期、高风险的研究能够 将扎实的基础科学成果转移到临床应用，并迁移挑衅性的临床 将观察结果带回实验室，以了解其机理基础。遴选的主要标准和 对发展(试点)项目的资助包括科学价值、与乳腺生物学和/或乳房的相关性 癌症、合作和校外同行评审资助的潜力。还有一个重点是 对新兴技术的利用和对年轻研究人员的培训。在当前的周期内，慷慨地 机构资金补充孢子预算，我们每年拨款20万美元支持21个试点项目 项目。这项投资已导致至少七项R01、ROI等值或K型奖励金 预算远远超过计划中的投资。此外，由三个DRP生成的数据具有 高度支持至少三名多调查员、P50类型或财团类型的拨款 制作了至少17份同行评审发表的手稿。四名由DRP资助的调查人员在 上一个周期现在是此竞争续订申请中的项目共同绩效指标和/或核心总监。 DRP由卡里奥斯·L·阿泰加、詹妮弗·皮滕波尔和斯科特·希伯特共同领导，他们都在 VICC。试点项目的申请面向范德比尔特和梅哈里医学中心的所有教职员工 以最大限度地扩大研究应用的数量和广度。共递交了54份申请， 在过去5年中，有21个项目获得了资助，资金率为39%。特别努力 旨在鼓励申请者的性别和种族多样性。申请将通过 多步骤过程。在7月份收到申请后，Arteaga博士、Pietenpol博士和Hiebert博士共同选择了2- 每个项目3名专家评审员。其中至少有一位是范德比尔特以外的评论家。

In an effort to promote excellent translational research in breast cancer, the Developmental Research Program (DRP) is a major focus of this Breast SPORE. The support of pilot projects allows eariy, high-risk research to move solid basic science findings toward clinical application as well as migrating provocative clinical observations back to the laboratory to understand their mechanistic basis. Main criteria for selection and funding of developmental (pilot) projects include scientific merit, relevance to mammary biology and/or breast cancer, collaboration, and potential for extramural peer-reviewed funding. There is also an emphasis on utilization of emerging technologies and on young investigators. During the current cycle and with generous institutional funds to supplement the SPORE budget, we have allocated $200,000 per year to support 21 pilot projects. This investment has resulted in at least seven R01, ROI equivalent, or K type grants for a combined budget well in excess of the investment made in the Program. In addition, data generated by three DRPs have been highly supportive of at least three multi-investigator, P50-type, or consortia type grants The DRP has also produced at least 17 peer-reviewed published manuscripts. Four investigators funded by the DRP during the last cycle are now Project co-PIs and or Core Directors in this competing renewal application. The DRP is co-led by Carios L. Arteaga, Jennifer Pietenpol, and Scott Hiebert, all with leadership roles at VICC. Applications for pilot projects are open to all Vanderbilt and Meharry Medical Center faculty members in order to maximize the number and breadth of research applications. Fifty-four applications were submitted and reviewed during the last 5 years of which 21 were funded, representing a funding rate of 39%. Special efforts are made to encourage gender and ethnic diversity among the applicants. Applications are reviewed through a multi-step process. After receiving the applications in July, Drs. Arteaga, Pietenpol and Hiebert jointly select 2- 3 expert reviewers per project. At least one of these is a reviewer from outside Vanderbilt.