Developmental Research Program

发展研究计划

• 批准号: 8764765
• 负责人: Carlos L Arteaga
• 金额: $ 6.58万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8764765
• 关键词: Applications Grants; Back; Basic Science; Biology; Breast; Budgets; Clinical; Collaborations; Data; Development; Emerging Technologies; Extramural Activities; Faculty; Foundations; Funding; Gender; Grant; Investigation; Investments; Laboratories; Leadership; Mammary gland; Manuscripts; Medical center; Metric; Peer Review; Pilot Projects; Process; Program Research Project Grants; Publications; Published Comment; Publishing Peer Reviews; Research; Research Personnel; Research Project Grants; Role; Selection Criteria; Solid; TNFRSF5 gene; The Vanderbilt-Ingram Cancer Center at the Vanderbilt University; Translational Research; United States National Institutes of Health; Writing; base; clinical application; high risk; innovation; malignant breast neoplasm; member; migration; programs

In an effort to promote excellent translational research in breast cancer, the Developmental Research Program (DRP) is a major focus of this Breast SPORE. The support of pilot projects allows eariy, high-risk research to move solid basic science findings toward clinical application as well as migrating provocative clinical observations back to the laboratory to understand their mechanistic basis. Main criteria for selection and funding of developmental (pilot) projects include scientific merit, relevance to mammary biology and/or breast cancer, collaboration, and potential for extramural peer-reviewed funding. There is also an emphasis on utilization of emerging technologies and on young investigators. During the current cycle and with generous institutional funds to supplement the SPORE budget, we have allocated $200,000 per year to support 21 pilot projects. This investment has resulted in at least seven R01, ROI equivalent, or K type grants for a combined budget well in excess of the investment made in the Program. In addition, data generated by three DRPs have been highly supportive of at least three multi-investigator, P50-type, or consortia type grants The DRP has also produced at least 17 peer-reviewed published manuscripts. Four investigators funded by the DRP during the last cycle are now Project co-PIs and or Core Directors in this competing renewal application. The DRP is co-led by Carios L. Arteaga, Jennifer Pietenpol, and Scott Hiebert, all with leadership roles at VICC. Applications for pilot projects are open to all Vanderbilt and Meharry Medical Center faculty members in order to maximize the number and breadth of research applications. Fifty-four applications were submitted and reviewed during the last 5 years of which 21 were funded, representing a funding rate of 39%. Special efforts are made to encourage gender and ethnic diversity among the applicants. Applications are reviewed through a multi-step process. After receiving the applications in July, Drs. Arteaga, Pietenpol and Hiebert jointly select 2- 3 expert reviewers per project. At least one of these is a reviewer from outside Vanderbilt.

为了促进乳腺癌领域优秀的转化研究，发展研究项目