Developmental Research Program

为了促进乳腺癌的优秀转化研究，发展研究计划 (DRP)是这次乳房孢子的主要焦点。对试点项目的支持使早期的高风险研究能够 将坚实的基础科学发现推向临床应用， 将观察结果带回实验室，以了解其机械基础。选择的主要标准和 对发展（试点）项目的资助包括科学价值、与乳腺生物学和/或乳腺 癌症，合作，以及校外同行评审资金的潜力。还有一个重点是 利用新兴技术和年轻的调查人员。在本周期内， 为了补充SPORE预算，我们每年拨款20万美元，支持21个试点项目， 项目这项投资已经导致了至少七个R 01，ROI等效，或K型赠款的组合 预算远远超过对该计划的投资。此外，三个DRP生成的数据 一直高度支持至少三个多研究者，P50型，或财团型赠款的DRP也 出版了至少17份同行评审的出版手稿。四名研究人员在 在此竞争性续约申请中，最后一个周期的项目共同PI和/或核心总监。 DRP由Carios L共同领导。Arteaga，Jennifer Pietenpol和Scott Hiebert，都在 VICC。试点项目的申请对所有范德比尔特和梅哈里医疗中心的教职员工开放， 以最大限度地提高研究应用的数量和广度。共提交了54份申请， 在过去5年中，对21个项目进行了审查，其中21个项目获得资助，资助率为39%。特别努力 鼓励申请人的性别和种族多样性。申请通过一个 多步骤过程。在7月收到申请后，Arteaga博士，Pietenpol和Hiebert共同选择了2- 每个项目3名专家审评员。其中至少有一个是来自范德比尔特以外的评论家。

In an effort to promote excellent translational research in breast cancer, the Developmental Research Program (DRP) is a major focus of this Breast SPORE. The support of pilot projects allows eariy, high-risk research to move solid basic science findings toward clinical application as well as migrating provocative clinical observations back to the laboratory to understand their mechanistic basis. Main criteria for selection and funding of developmental (pilot) projects include scientific merit, relevance to mammary biology and/or breast cancer, collaboration, and potential for extramural peer-reviewed funding. There is also an emphasis on utilization of emerging technologies and on young investigators. During the current cycle and with generous institutional funds to supplement the SPORE budget, we have allocated $200,000 per year to support 21 pilot projects. This investment has resulted in at least seven R01, ROI equivalent, or K type grants for a combined budget well in excess of the investment made in the Program. In addition, data generated by three DRPs have been highly supportive of at least three multi-investigator, P50-type, or consortia type grants The DRP has also produced at least 17 peer-reviewed published manuscripts. Four investigators funded by the DRP during the last cycle are now Project co-PIs and or Core Directors in this competing renewal application. The DRP is co-led by Carios L. Arteaga, Jennifer Pietenpol, and Scott Hiebert, all with leadership roles at VICC. Applications for pilot projects are open to all Vanderbilt and Meharry Medical Center faculty members in order to maximize the number and breadth of research applications. Fifty-four applications were submitted and reviewed during the last 5 years of which 21 were funded, representing a funding rate of 39%. Special efforts are made to encourage gender and ethnic diversity among the applicants. Applications are reviewed through a multi-step process. After receiving the applications in July, Drs. Arteaga, Pietenpol and Hiebert jointly select 2- 3 expert reviewers per project. At least one of these is a reviewer from outside Vanderbilt.