An integrated molecular approach to understand variation in iron metabolism
了解铁代谢变化的综合分子方法
基本信息
- 批准号:8501536
- 负责人:
- 金额:$ 66.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-07-01 至 2016-05-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAffectAnemiaAnemia due to Chronic DisorderCandidate Disease GeneChromosome MappingChronic DiseaseClinicalComputer SimulationDataDeficiency DiseasesDietDiseaseEatingFatigueFishesGene ExpressionGene Expression ProfilingGenesGeneticGenetic VariationGenotypeHaplotypesHealthHemoglobin concentration resultHomeostasisHomologous GeneHumanInbred MouseInbred StrainInbred Strains MiceInbreedingIndividualIntestinesIronIron Metabolism DisordersIron OverloadLiverMaintenanceMalnutritionMapsModelingMolecularMorbidity - disease rateMusNutritionalOrthologous GenePatientsPersonsPhenotypePlayPredispositionQuantitative Trait LociRecombinantsResearchResolutionRodentRoleSNP genotypingSamplingSeveritiesSingle Nucleotide Polymorphism MapStressTestingTimeTissuesVariantVertebratesWorkZebrafishabsorptionbaseeffective therapyhepcidinhuman population studyimmune functionimprovedinsightiron deficiencyiron metabolismknock-downmacrophagemanmortalitymutantpopulation basedresponsetraittranscriptome sequencing
项目摘要
DESCRIPTION (provided by applicant): Disturbances of iron homeostasis can have significant clinical consequences. Iron deficiency is the world's most prominent nutritional deficiency and anemia of chronic disease (ACD) from decreased intestinal iron absorption and impaired iron release from macrophages is common in hospitalized patients. The overall aim of this study is to help us understand the genetic basis of variation in iron metabolism between people. Inbred mice show significant variation in multiple traits including iron metabolism. We propose to identify loci underlying strain specific differences in iron metabolism through a combination of in silico SNP association and gene expression profiling. We will test candidate genes for iron related function in Zebrafish, a complementary vertebrate model. Finally, we will assess candidate genes for a role in human iron metabolism through population based studies. We have assembled a multi- disciplinary research team of iron metabolism biologists, geneticists and computational biologists to carry out the proposed study.
描述(由申请人提供):铁稳态紊乱可导致严重的临床后果。缺铁是世界上最突出的营养缺乏症,慢性疾病贫血(ACD)由肠道铁吸收减少和巨噬细胞铁释放受损引起,在住院患者中很常见。这项研究的总体目的是帮助我们了解人与人之间铁代谢差异的遗传基础。近交系小鼠在铁代谢等多种性状上表现出显著差异。我们建议通过结合硅SNP关联和基因表达谱来确定菌株铁代谢特异性差异的位点。我们将在斑马鱼(一种互补的脊椎动物模型)中测试铁相关功能的候选基因。最后,我们将通过基于人群的研究评估候选基因在人体铁代谢中的作用。我们组建了一个由铁代谢生物学家、遗传学家和计算生物学家组成的多学科研究团队来开展这项研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CHRISTOPHER D VULPE其他文献
CHRISTOPHER D VULPE的其他文献
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{{ truncateString('CHRISTOPHER D VULPE', 18)}}的其他基金
Supplement: CRISPR screens of population relevant genes governing toxicant resilience
补充:CRISPR 筛选控制毒物抵抗力的群体相关基因
- 批准号:
10720972 - 财政年份:2023
- 资助金额:
$ 66.97万 - 项目类别:
CRISPR screens of population relevant genes governing toxicant resilience
CRISPR 筛选控制毒物抵抗力的群体相关基因
- 批准号:
10337726 - 财政年份:2022
- 资助金额:
$ 66.97万 - 项目类别:
CRISPR screens of population relevant genes governing toxicant resilience
CRISPR 筛选控制毒物抵抗力的群体相关基因
- 批准号:
10573193 - 财政年份:2022
- 资助金额:
$ 66.97万 - 项目类别:
Functional Profiling to Identify Mitochondria-cell Signaling Networks
识别线粒体细胞信号网络的功能分析
- 批准号:
9068923 - 财政年份:2015
- 资助金额:
$ 66.97万 - 项目类别:
An integrated molecular approach to understand variation in iron metabolism
了解铁代谢变化的综合分子方法
- 批准号:
8669002 - 财政年份:2012
- 资助金额:
$ 66.97万 - 项目类别:
An integrated molecular approach to understand variation in iron metabolism
了解铁代谢变化的综合分子方法
- 批准号:
8885844 - 财政年份:2012
- 资助金额:
$ 66.97万 - 项目类别:
An integrated molecular approach to understand variation in iron metabolism
了解铁代谢变化的综合分子方法
- 批准号:
8238272 - 财政年份:2012
- 资助金额:
$ 66.97万 - 项目类别:
Project 2: Functional Profiling of Susceptibility Genes
项目2:易感基因的功能分析
- 批准号:
8063132 - 财政年份:2010
- 资助金额:
$ 66.97万 - 项目类别:
Integrated nanoparticle characterizaton and toxicity assessment
综合纳米颗粒表征和毒性评估
- 批准号:
7939794 - 财政年份:2009
- 资助金额:
$ 66.97万 - 项目类别:
Integrated nanoparticle characterizaton and toxicity assessment
综合纳米颗粒表征和毒性评估
- 批准号:
7854985 - 财政年份:2009
- 资助金额:
$ 66.97万 - 项目类别:
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