Integrated nanoparticle characterizaton and toxicity assessment

综合纳米颗粒表征和毒性评估

• 批准号: 7939794
• 负责人: CHRISTOPHER D VULPE
• 金额: $ 38.48万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-26 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7939794
• 关键词: Address; Adverse effects; Affect; Arts; Behavior; Biological; Breathing; Caliber; Carbon Nanotubes; Cells; Chemistry; Collaborations; Environment; Gene Expression; Health; Human; In Situ; Ions; Knowledge; Lead; Length; Lung; Metals; Nanotechnology; Property; Rattus; Research; Research Priority; Risk; Risk Assessment; Role; Safety; Screening procedure; Shapes; Silicon Dioxide; Silver; Solutions; Staging; Structure of parenchyma of lung; Surface; System; Testing; Toxic effect; Toxicology; Work; aqueous; chemical stability; consumer product; expectation; light scattering; meetings; nanomaterials; nanoparticle; nanotoxicology; nanowire; novel strategies; public health relevance

DESCRIPTION (provided by applicant): While it is now recognized that the manufacture of nanomaterials may present unique risks to humans and the environment, the field of nanotoxicology remains at an early stage. Nanomaterials, the building blocks of nanotechnology, constitute a very diverse range of compounds. They include low dimensionality materials such as C60 and inorganic nanoparticles (NP), and one-dimensional materials such as carbon nanotubes and the focus of this study, inorganic nanowires (NW). With the exception of studies of carbon nanotubes, most toxicology studies have assessed the impacts of inorganic nanoparticles. There is a growing expectation that inorganic nanowires may be more broadly utilized than other nanomaterials but there is a remarkable lack of safety information on these compounds. We therefore propose a collaboration between environmental chemists and toxicologists to develop the knowledge to minimize the risks of nanowires to human health. We will focus in this proposal on silver nanowires of varying lengths and diameters as a representative of this class of nanomaterials. We will address three inter-related questions in our work. What is the role of the intrinsic physicochemical properties of nanowires on their behavior in different environments? What is the relationship between nanowire properties and the environment on cellular and organismal toxicity? And what are the mechanisms by which nanowires lead to adverse effects in these systems? We propose to develop new approaches for the assessment of nanowire properties and toxicity which could have general applicability for assessment of other nanomaterials of concern. PUBLIC HEALTH RELEVANCE: Nanowires are a form of nanomaterials that are expected to be used in a broad array of commercial and consumer products. Despite their likely wide spread use, there is very limited information on the safety of nanowires. We propose to assess the safety of nanowires using state of the art toxicology approaches.

描述（由申请人提供）：虽然现在认识到纳米材料的制造可能对人类和环境构成独特的风险，但纳米毒理学领域仍处于早期阶段。纳米材料是纳米技术的基石，构成了一系列非常多样化的化合物。它们包括低维材料，如C60和无机纳米颗粒（NP），和一维材料，如碳纳米管和本研究的重点，无机纳米线（NW）。除了对碳纳米管的研究外，大多数毒理学研究都评估了无机纳米颗粒的影响。人们越来越期望无机纳米线可能比其他纳米材料更广泛地使用，但这些化合物的安全信息明显缺乏。因此，我们建议环境化学家和毒理学家之间的合作，以发展知识，以尽量减少纳米线对人类健康的风险。我们将集中在这个建议上的银纳米线的长度和直径不同，这类纳米材料的代表。我们将在工作中处理三个相互关联的问题。纳米线的内在物理化学性质对它们在不同环境中的行为有什么作用？纳米线的特性与环境对细胞和生物毒性的影响有什么关系？纳米线在这些系统中导致不利影响的机制是什么？我们建议开发新的方法来评估纳米线的性能和毒性，这可能具有普遍适用性的评估其他纳米材料的关注。 公共卫生相关性：纳米线是一种纳米材料，预计将用于广泛的商业和消费产品。尽管它们可能广泛使用，但关于纳米线安全性的信息非常有限。我们建议使用最先进的毒理学方法来评估纳米线的安全性。