Mathematical models of membrane biophysics and microbial locomotion

膜生物物理学和微生物运动的数学模型

• 批准号: 8656718
• 负责人: George Karlsson Roderick
• 金额: $ 18.16万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8656718
• 关键词: Address; Attention; Automobile Driving; Back; Bacteria; Biophysics; Categories; Collaborations; Cyanobacterium; Endocytosis; Endoplasmic Reticulum; Flavobacteria; Flavobacterium genus; Freedom; Geometry; Goals; Grant; Growth; Laboratories; Lead; Lipids; Locomotion; Marines; Membrane; Methods; Modeling; Modus; Myxococcales; Myxococcus xanthus; Organelles; Organism; Process; Property; Research; Role; Shapes; Structure; Swimming; Synechococcus; System; Testing; Vesicle; Work; base; biological systems; cell motility; experience; falls; gliding bacteria; mathematical model; membrane model; microbial; novel; professor; research study

DESCRIPTION (provided by applicant): The research undertaken during the period of this grant falls into two general categories (i) membrane biophysics and (ii) bacterial propulsion. This work will be performed in collaboration and/or correspondence with experimental laboratories engaged in studies on specific organisms. The models will be primarily directed towards understanding and explaining their experimental observations. However, previous experience assures that models directed at particular biological systems frequently lead to general principles that apply to a wider range of phenomena. The specific goals of this project are to model the following systems. 1. Membrane dynamics. We will address the formation of lipid droplets from the endoplasmic reticulum (ER) using models of lipid tilt. We consider this degree of freedom essential to explain vesicle fusion and scission that involve topological changes in membrane geometry. Using continuum models of lipid tilt, we will focus on the initiation and growth of the bud and its subsequent scission. Our model also allows us to model the flow of lipid in the membrane. This is important in dramatic membrane shape changes such as that in the cubic-to-lamellar transition in intracellular organelles. This work will be carried out in collaboration with Prof. D. Steigmann (UC Berkeley). 2. Bacterial propulsion. We will address novel propulsive mechanisms that have not been previously modeled, and for which experimental observations provide clues to their modus operandi. Our attention will be directed at (i) the gliding A-motility system of Myxococcus xanthus and related bacteria (e.g. Flavobacteria), and (ii) the swimming of the cyanobacterium, Synechococcus. This work will be carried out in collaboration with the experimental laboratories of Professor D. Zusman (UC Berkeley) and Dr. B. Brahamsha (Scripps). The mathematical modeling will be carried out in collaboration with Professor J. Neu (UC Berkeley).

描述（由申请人提供）：在此资助期间进行的研究分为两大类(i)膜生物物理学和（ii）细菌推进。这

项目成果

Lipid tubule growth by osmotic pressure.

脂质小管通过渗透压生长。

• DOI: 10.1098/rsif.2013.0637
• 发表时间: 2013
• 期刊: Journal of the Royal Society, Interface
• 作者: Rangamani,Padmini;Zhang,Di;Oster,George;Shen,AmyQ
• 通讯作者: Shen,AmyQ

Interaction between surface shape and intra-surface viscous flow on lipid membranes.

• DOI: 10.1007/s10237-012-0447-y
• 发表时间: 2013-08
• 期刊: BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
• 影响因子: 3.5
• 作者: Rangamani, Padmini;Agrawal, Ashutosh;Mandadapu, Kranthi K.;Oster, George;Steigmann, David J.
• 通讯作者: Steigmann, David J.

Dual biochemical oscillators may control cellular reversals in Myxococcus xanthus.

双生化振荡器可以控制黄色粘球菌的细胞逆转。

• DOI: 10.1016/j.bpj.2014.09.046
• 发表时间: 2014
• 期刊: Biophysical journal
• 影响因子: 3.4
• 作者: Eckhert,Erik;Rangamani,Padmini;Davis,AnnieE;Oster,George;Berleman,JamesE
• 通讯作者: Berleman,JamesE

On the mysterious propulsion of Synechococcus.

• DOI: 10.1371/journal.pone.0036081
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Ehlers K;Oster G
• 通讯作者: Oster G

Small scale membrane mechanics.

小尺度膜力学。

• DOI: 10.1007/s10237-013-0528-6
• 发表时间: 2014
• 期刊: Biomechanics and modeling in mechanobiology
• 影响因子: 3.5
• 作者: Rangamani,Padmini;Benjamini,Ayelet;Agrawal,Ashutosh;Smit,Berend;Steigmann,DavidJ;Oster,George
• 通讯作者: Oster,George