CRCNS: Integrated Empirical and Multi-scale Modeling of Human Sleep Spindles

CRCNS：人类睡眠纺锤波的综合经验和多尺度建模

• 批准号: 8656621
• 负责人: TERRENCE J SEJNOWSKI
• 金额: $ 52.89万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-08 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8656621
• 关键词: Action Potentials; Animals; Attention; Biophysical Process; Boundary Elements; Brain; Calcium; Cell Nucleus; Cells; Cerebral cortex; Computer Simulation; Cortical Column; Coupled; Data; Electrocorticogram; Electrodes; Electroencephalogram; Elements; Event; Experimental Models; Generations; Goals; Hodgkin Disease; Human; Hybrids; Interneurons; Investigation; Link; Location; Magnetic Resonance Imaging; Mammals; Measurement; Measures; Memory; Methods; Microelectrodes; Microscopic; Modeling; Neurobiology; Neurons; Neurosciences; Pattern; Phase; Physiological; Principal Component Analysis; Pyramidal Cells; Recruitment Activity; Research; Role; SHFM1 gene; Scalp structure; Sleep; Sleep Disorders; Source; Specific qualifier value; Surface; Synapses; System; Techniques; Testing; Thalamic Nuclei; Thalamic structure; Time; Waxes; Work; base; biophysical model; computer studies; cranium; density; magnetoencephalogram; multi-scale modeling; neural circuit; neural model; novel; relating to nervous system

DESCRIPTION (provided by applicant): Neural oscillations organize cortico-thalamic activity, and their role in memory, attention and sleep are a central focus of systems neuroscience. Sleep spindles are among the most prominent oscillations, and have been studied at many levels of investigation, from the biophysical level, where the low threshold calcium currents are implicated in the waxing-and-waning 11-15 Hz bursts of spikes that originate in the thalamus and recruit cortical circuits, to the systems level where the electroencephalogram (EEG) and magnetoencephalogram (MEG) measured outside the skull register largescale spatial and temporal coherence in the bursting pattern across the cortex (Destexhe and Sejnowski, 2001). Despite the wealth of physiological, anatomical and computational studies, major questions remain to be resolved: How do nearby parts of the cortex become synchronized during spindles? How are spindles propagated across the cortex? Why is there a discrepancy between the temporal patterns of spindles simultaneously observed in EEG and MEG measurements? What are the consequences of spindle activity in thalamocortical systems for cortical reorganization and memory consolidation during sleep? We propose to attack these questions with a range of experimental and modeling techniques that 1) link detailed models at the biophysical level to recordings from humans at the level of current source density analysis (CSD) recordings from depth electrodes; and 2) relate large scale reduced models of cortical circuits to EEG and MEG measurements in humans. This is the first time that all of these powerful empirical and modeling approaches have been integrated into a single, multiscale approach to understanding the origin of macroscopic field measurements outside the scalp based on the specific biophysical mechanisms occurring in neurons located in different layers of the cortex and thalamus.

描述（由申请人提供）：神经振荡组织皮质-丘脑活动，它们在记忆、注意力和睡眠中的作用是系统神经科学的中心焦点。睡眠纺锤波是最突出的振荡之一，并且已经在许多调查水平上进行了研究，从生物物理水平，其中低阈值钙电流与起源于丘脑并招募皮质回路的11-15 Hz尖峰脉冲的起伏有关，到系统层面，脑电图（EEG）和脑磁图（MEG）在颅骨外测量，记录了大脑皮层上爆发模式的大尺度空间和时间相干性（Destexhe和Sejnowski，2001年）。尽管有大量的生理学、解剖学和计算研究，但主要的问题仍然有待解决：在纺锤波期间，皮层的邻近部分是如何同步的？纺锤波是如何在大脑皮层中传播的？为什么在EEG和MEG测量中同时观察到的纺锤波的时间模式之间存在差异？在睡眠中，丘脑皮质系统的纺锤体活动对皮质重组和记忆巩固有什么影响？我们建议用一系列实验和建模技术来解决这些问题，这些技术包括：1）将生物物理水平的详细模型与来自深度电极的电流源密度分析（CSD）记录水平的人类记录联系起来; 2）将大规模的皮层电路简化模型与人类的EEG和MEG测量结果联系起来。这是第一次，所有这些强大的经验和建模方法已被集成到一个单一的，多尺度的方法来理解头皮外的宏观场测量的起源基于特定的生物物理机制发生在位于不同层的皮层和丘脑的神经元。