PS11-003 Minority AIDS Research Initiative

PS11-003 少数民族艾滋病研究计划

• 批准号: 8403466
• 负责人: Bridgette Mercedez Rice
• 金额: $ 27.27万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8403466
• 关键词: PS11; 003; Minority; AIDS; Research

Project Summary This application is responsive to the fourth research topic in Request for Applications RFA-PS-11-003, "A Sexual Health Approach for Black and Hispanic Youth: New strategies for prevention, screening and facilitating healthy choices." In Philadelphia, PA, urban Black adolescents are disproportionately impacted by unintended sexual outcomes, such as HIV, sexually transmitted infections (STIs) and unwanted pregnancies. Novel studies translated into nontraditional community programs to address overall sexual health and decrease sexual infections are essential for this population. The proposed study is an effort to translate the Principal Investigator's (PI's) preliminary research findings to benefit sexual health education needs identified within the local adolescent mental health community. The PI innovatively proposes the first steps in a program of research to address HIV/STI prevention needs in a historically underserved sector of the Black community- Black adolescents suffering from mental illnesses. The applicant is a young African American nurse scientist with a proven track record to implement culturally and linguistically competent research methodology, a history of service to Black communities, strong linkages to the targeted population and outstanding research training through the Center for Health Equity Research at the University of Pennsylvania School of Nursing. Accordingly, a community-based participatory research (CBPR) framework is proposed with mentorship by renowned senior scientists, Drs. Loretta Jemmott and Gina Wingood. Hard to reach, disenfranchised adolescents are at the epicenter of our national HIV/STI epidemic, and those with mental health illnesses are at heightened risk. Early sexual debut, substance abuse, poverty and limited educational attainment are all documented risk factors. Black adolescents with mental illnesses are at increased risk for HIV/STIs because they are more likely to encounter social and structural drivers of the HIV/STI epidemic. Further, research indicates that they engage in HIV/STI risk related sexual behaviors at higher rates than other adolescents. The delivery of HIV/STI prevention programming in a nontraditional setting, such as an outpatient mental health treatment program, may prove effective to engage at-risk Black adolescents with mental illnesses. Behavioral interventions have demonstrated efficacy in the general adolescent population; however, it remains unknown whether these findings translate to adolescents with mental illnesses. To enhance efficacy, interventions for this population should be targeted to account for unique social and psychological factors which may impair their ability to accurately appraise risky situations, control impulses and negotiate condom use. Despite these facts, a paucity of comprehensive evidence-based interventions are available to reduce HIV/STI risk among Black adolescents with mental illnesses. Through a health equity lens, and a social determinants approach to HIV/STI prevention, the purpose of this study is to develop and pilot a theoretically-driven, gender and culturally relevant, developmentally and psychologically appropriate behavioral intervention to reduce the risk of HIV/STIs among heterosexually-active Black adolescents (ages 13 to 17) with mental illnesses. A CBPR framework, the Theory of Planned Behavior, and the investigators' preliminary work with the target population will guide the research process. Both males and females (N= 128) currently receiving outpatient mental health treatment from a Philadelphia Community Behavioral Health (CBH) provider will be randomized to one of two conditions: 1) a targeted HIV/STI risk reduction intervention to reduce their risk of HIV and other STIs; or 2) an attention control condition on general health promotion to reduce their risk of adverse health conditions including cancer, obesity, and heart disease. In partnership with the community, the specific aims are focused on elucidation of factors that influence HIV/STI risk, intervention development, testing the intervention's effects on HIV/STI risk related sexual behavior and STI incidence, and testing the mediation of effects of the intervention. The primary study outcome is self-reported consistent condom use assessed at baseline, immediately post-intervention, and at 3-, 6- and 12-month follow-ups. Secondary outcomes include sexual activity, the number of concurrent and sequential sexual partners, the theoretical mediators of intervention effects (adolescents' attitudes, beliefs, intentions and self-efficacy) and laboratory confirmed STIs. These data will contribute to the development of evidence-based HIV/STI sexual risk reduction programs for Black adolescents with mental illnesses. Specifically, the intended impact is to: 1) generate data to address unique, unmet HIV/STI risk reduction needs via a gender and culturally relevant, developmentally and psychologically appropriate vehicle targeted to reach Black adolescents with mental illnesses; 2) partner with community stakeholders to deliver a novel intervention in a nontraditional setting embedded in the community at risk to enhance sexual health dialogue and prevention efforts between adolescents and trusted adult facilitators; and 3) inform mental health policy toward the standardization of sexual health assessment and intervention in community outpatient mental health treatment. The investigator's long-term goal is to build an HIV epidemiologic prevention program of research focused on decreasing HIV/STI morbidity in highly affected urban Philadelphia, and generalizable to other urban communities. Given that adolescent health is imperative to public health, the proposed research is timely, innovative and bears great significance.

项目摘要 本申请响应申请请求RFA-PS-11-003中的第四个研究主题，“A 黑人和西班牙裔青年的性健康方法：预防，筛查和预防的新策略 促进健康的选择。“在费城，宾夕法尼亚州，城市黑人青少年受到不成比例的影响， 意外的性后果，如艾滋病毒、性传播感染和意外怀孕。 新的研究转化为非传统的社区计划，以解决整体性健康和 减少性感染对这一人群至关重要。拟议的研究是一项努力， 主要研究者（PI）的初步研究结果有助于确定性健康教育需求 在当地的青少年心理健康社区。PI创新性地提出了计划的第一步 在黑人社区一个历来得不到充分服务的部门开展研究，以满足艾滋病毒/性传播感染预防需求- 患有精神疾病的黑人青少年。申请人是一位年轻的非裔美国护士科学家 在实施文化和语言能力强的研究方法方面， 服务黑人社区的历史，与目标人群的紧密联系和杰出的研究 通过宾夕法尼亚大学护理学院健康公平研究中心进行培训。 因此，提出了一个基于社区的参与式研究（CBPR）框架， 著名的资深科学家洛蕾塔·杰莫特博士和吉娜·温古德博士很难接触到被剥夺了公民权 青少年是我们国家艾滋病毒/性传播感染流行病的中心，那些患有心理健康疾病的人 处于更高的风险中过早的初次性行为、药物滥用、贫困和受教育程度有限都是 记录的风险因素。患有精神疾病的黑人青少年感染艾滋病毒/性传播感染的风险增加， 他们更有可能遇到艾滋病毒/性传播感染流行病的社会和结构性驱动因素。此外，研究 表明他们从事艾滋病毒/性传播感染风险相关的性行为的比率高于其他青少年。的 在非传统环境中提供艾滋病毒/性传播感染预防方案，如门诊心理健康 治疗计划，可能会证明有效地从事风险黑人青少年与精神疾病。行为 干预措施已在一般青少年人群中证明有效;然而， 这些发现是否适用于患有精神疾病的青少年。为了提高效力， 应针对这一人群，以考虑可能损害其健康的独特社会和心理因素 他们准确评估危险情况、控制冲动和协商使用安全套的能力。尽管有这些 事实上，缺乏全面的循证干预措施，以减少艾滋病毒/性传播感染的风险， 患有精神疾病的黑人青少年。通过健康公平透镜和社会决定因素方法， 艾滋病毒/性传播感染预防，这项研究的目的是制定和试点一个理论驱动的，性别和 文化上相关的，发展和心理上适当的行为干预，以减少风险 患有精神疾病的异性恋黑人青少年（13至17岁）中的艾滋病毒/性传播感染率。A CBPR 框架，计划行为理论，以及调查人员对目标人群的初步工作 将指导研究过程。男性和女性（N= 128）目前接受门诊心理健康 来自费城社区行为健康（CBH）提供者的治疗将被随机分配到两个治疗组之一。 条件：1）有针对性的艾滋病毒/性传播感染风险降低干预措施，以降低他们感染艾滋病毒和其他性传播感染的风险;或2） 一般健康促进的注意力控制条件，以减少他们出现不良健康状况的风险 包括癌症、肥胖症和心脏病。在与社区的伙伴关系中， 阐明影响艾滋病毒/性传播感染风险的因素，制定干预措施，测试干预措施， 对HIV/STI风险相关性行为和STI发病率的影响，并测试 干预主要的研究结果是自我报告的安全套使用一致性评估基线， 干预后即刻以及3个月、6个月和12个月随访时。次要结果包括性 活动，同时和连续性伴侣的数量，干预的理论中介 影响（青少年的态度，信仰，意图和自我效能）和实验室确认的性传播感染。这些数据 将有助于制定以证据为基础的减少黑人艾滋病毒/性传播感染风险的计划 患有精神疾病的青少年。具体而言，预期的影响是：1）生成数据以解决唯一， 通过性别和文化相关性、发展和心理方面的 有针对性地接触患有精神疾病的黑人青少年的适当工具; 2）与社区合作 利益攸关方在嵌入风险社区的非传统环境中提供新的干预措施， 加强青少年与值得信赖的成人促进者之间的性健康对话和预防工作; 3)为性健康评估和干预的标准化提供信息， 社区门诊心理健康治疗。研究人员的长期目标是建立一个艾滋病毒 一项流行病学预防研究计划，重点是降低艾滋病毒/性传播感染发病率， 城市费城，并推广到其他城市社区。鉴于青少年健康是当务之急 对公共卫生而言，本研究具有时代性、创新性和重要意义。