High Density Surface EMG Assessment of Motor Unit Alterations after Stroke

中风后运动单位改变的高密度表面肌电图评估

• 批准号: 8694681
• 负责人: ping zhou
• 金额: $ 33.63万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8694681
• 关键词: Action Potentials; Address; Atrophic; Behavior; Behavior monitoring; Benign; Cessation of life; Clinical; Clinical Research; Complex; Contracture; Contralateral; Data; Data Collection; Denervation; Development; Discrimination; Disease; Electrodes; Examinations and Diagnoses; Functional disorder; Goals; Impairment; Incidence; Individual; Lesion; Limb structure; Mechanics; Motor; Motor Neurons; Muscle; Muscle Fibers; Muscle Weakness; Muscle function; Needles; Nerve; Nonlinear Dynamics; Patients; Pattern; Pharmaceutical Preparations; Pilot Projects; Play; Prevalence; Process; Property; Rehabilitation device; Relative (related person); Research; Research Project Grants; Rest; Role; Spastic; Spinal; Stroke; Surface; Survivors; Symptoms; Techniques; Time; base; chronic stroke; density; functional loss; improved; nerve supply; novel; post stroke; public health relevance; rehabilitation strategy; reinnervation; restoration

DESCRIPTION (provided by applicant): The long-term goal of this research project is to understand the complicated origins of muscle weakness after a hemispheric stroke, and also to explore the origins of the associated muscle fiber loss, contracture, and other key intrinsic property changes of the spastic-paretic muscles. Specifically, we seek to use the most recent advances in high density surface electromyogram (EMG) recording and processing techniques to determine whether these features involve alterations in different motor unit components after an upper motoneuron lesion. The basic clinical and research questions will be addressed via four specific aims. Aim 1 is to assess whether there is active motoneuron degeneration or signs of impending motoneuron death, by examining the patterns of spontaneous discharge in resting paretic muscles of stroke survivors. Aim 2 is to assess whether there is evidence for spinal motoneuron degeneration by estimating the motor unit number loss in paretic muscles of stroke survivors. Aim 3 is to examine alterations in motor unit control properties post stroke using recent advances in high density surface EMG decomposition. Aim 4 is to examine muscle fiber atrophy, denervation/reinnervation changes post stroke using a range of novel quantitative motor unit action potential (MUAP) analyses. Beyond the major scope of the proposal, several pilot studies are planned as well to extract as much useful information as possible for an improved understanding of motor unit property in stroke. The proposed research using novel high density surface EMG techniques will enhance our understanding of the pathophysiology of muscle weakness and other associated changes after stroke, thus providing guidance for the development of rehabilitation strategies and devices for restoration of normal muscle functions. The findings from the novel high density surface EMG techniques will also have important clinical value to diagnosis, examination and medication/therapy study of stroke.

描述（由申请人提供）：该研究项目的长期目标是了解半球中风后肌肉无力的复杂起源，并探索相关的肌肉纤维损失，缔合，缔合以及其他痉挛性肌肉的其他关键内在特性变化的起源。具体而言，我们试图使用高密度表面肌电图（EMG）记录和加工技术的最新进展来确定这些特征是否涉及上部运动神经元病变后不同运动单位成分的改变。基本的临床和研究问题将通过四个特定目标解决。目的1是通过检查中风幸存者的静止偏度肌肉中的自发放电模式，来评估是否有活跃的运动神经元变性或即将发生的运动神经元死亡的迹象。 AIM 2是通过估计中风幸存者偏肌的运动单位数损失来评估是否有证据表明脊柱运动神经元变性。 AIM 3是使用高密度表面EMG分解的最新进展来检查中风后运动单位控制特性的变化。 AIM 4是使用一系列新型的定量运动单位动作电位（MUAP）分析检查中风后进行肌肉纤维萎缩，神经支配/重新连接变化。除了该提案的主要范围外，还计划了一些试点研究，以提取尽可能多的有用信息，以提高对中风中运动单位特性的了解。提出的使用新型高密度表面EMG技术的研究将增强我们对中风后肌肉无力和其他相关变化的病理生理学的理解，从而为发展康复策略的发展提供了指导，并为恢复正常肌肉功能的设备提供了指导。新型高密度表面EMG技术的发现也将对中风的诊断，检查和药物治疗研究具有重要的临床价值。