NINDS Center Core at the University of Minnesota

这是一项关于NINDS机构中心核心拨款的提案，以支持明尼苏达大学的神经科学研究。该中心及其核心的使命是通过提供最先进的共享设备设施和技术和科学支持，加强神经系统的基础和转化性研究。该中心汇集了由NINDS资助的11名研究人员组成的主要小组，他们使用小鼠模型研究人类神经系统疾病/障碍和神经系统功能。该中心还高度重视帮助新的神经科学研究人员建立他们的研究计划和NINDS资助的研究人员，而不需要合格的拨款。该中心还在可能的情况下向一大批研究人员提供服务和资源，这些研究人员中有许多是由NIH资助的，他们的研究重点是神经系统。 这三个研究中心提供技术服务、培训和科学专长，以提高生产率，促进新的研究方向，并促进中心调查人员之间的合作。选择这些核心是为了提供广泛需要的、甚至是关键的工具，用于研究老鼠模型。这些工具最好在一个中央设施中提供，在那里，调查人员可以利用标准化和优化的方案以及专家技术援助。选择这些核心也是为了提供新的、强大的工具，用于调查神经系统功能/功能障碍，这是个别研究人员通常无法获得的。通过专注于对小鼠模型的研究和评估，跨核心的创新协同效应具有很高的潜力。 基因操作核心提供细菌人工染色体转基因小鼠和病毒载体的生成，以在体外和体内操作基因表达。行为表型核心为评估小鼠的一系列运动和认知行为以及一般神经状态提供了设施和技术支持。成像和轨迹跟踪核心为研究人员提供现代成像(单光子和双光子显微镜)、轨迹跟踪/组织学和依赖活动的光学成像的工具和专业知识。执行委员会的第四个行政核心负责中心的监督，管理机构共享计划，促进合作，向神经科学界提供信息，寻求新技术，并评估中心的业绩。该中心和核心将提高NINDS资助的研究人员的影响力和生产率，促进新的研究方向，并促进中心研究人员之间的合作。

This is a proposal for an NINDS Institutional Center Core grant to support neuroscience research at the University of Minnesota. The mission of the Center and its Cores is to enhance basic and translational research on the nervous system by providing state-of-the art, shared equipment facilities with technical and scientific support. The Center brings together a primary group of 11 NINDS-funded investigators using mouse models to study human neurological disease/disorders and nervous system function. The Center also gives high priority to helping new neuroscience investigators establish their research programs and NINDS-funded investigators without qualifying grants. The Center also offers its services and resources when possible to a large group of investigators, many NIH funded, whose research is focused on the nervous system. The three research Cores provide technological services, training and scientific expertise to increase productivity, promote new research directions and foster collaborations among Center investigators. The Cores were selected to provide access to widely needed, even critical, tools used in the study of mouse models. These tools are best offered in a central facility in which investigators can take advantage of standardized and optimized protocols as well as expert technical assistance. The Cores were also selected to provide access to new, powerful tools for the investigation of nervous system function/dysfunction not generally available to individual investigators. By focusing on the study and evaluation of mouse models, there is a high potential for innovative synergistic effects across the Cores. The Genetic Manipulation Core provides the generation of bacterial artificial chromosome transgenic mice and viral vectors to manipulate gene expression in vitro and in vivo. The Behavioral Phenotyping Core provides facilities and technical support for the evaluation of a spectrum of motor and cognitive behaviors as well as general neurological status in the mouse. The Imaging and Tract Tracing Core provides investigators with the tools and expertise for modern imaging (single and two-photon microscopy), tract tracing/histology, and activity-dependent optical imaging. The fourth Administrative Core with the Executive Committee is responsible for Center oversight, administers the institutional sharing plan, promotes collaborations, informs the neuroscience community, seeks new technologies and evaluates the performance of the Center. The Center and Cores will increase the impact and productivity of NINDS-funded investigators, promote new research directions and foster collaborations among Center researchers.