Determining the Functional Contribution of Prostate Tumor Microenvironment in Bon

项目摘要：在此项目中，我们建议解决功能 低氧的作用 微环境(TME)对前列腺癌进展和骨转移的影响 疾病。本项目使用在项目1中生成的鼠标模型来研究 人前列腺癌中缺氧、EMT和肌成纤维细胞代谢的研究及验证 组织。这些研究将在合作斯卡登实验室(项目3)进行，该实验室将 确定可能与骨转移相关的骨细胞成分。我们也 建议详细评估癌细胞模拟间充质细胞的能力的获得 细胞类型，并经历上皮向间充质转化(EMT)的程序，希望 收集信息以确定治疗转移性前列腺癌的新靶点 癌症。

Project Summary: In this project, we propose to address the functional contribution of hypoxic microenvironment (TME) to the progression of prostate cancer and emergence of metastatic bone disease. This project use the mouse models generated in the Project 1 to study the influence of hypoxia, EMT and myofibroblasts metabolism and validate these finding in human prostate cancer tissue. Such studies will be performed in collaboration Scadden Laboratory (Project 3), which will determine the cellular components of the bone that likely cooperate with bone metastasis. We also propose to evaluate in detail the acquisition of the ability of cancer cell to mimic mesenchymal cell types and undergo a program of epithelial to mesenchymal transition (EMT), in hopes of gathering information to identify new therapeutic targets against metastatic prostate cancer.