Mentoring Behavioral Scientists for Career Development in Pediatric T1D Research

描述（由申请人提供）：为了回应 RFA-DK-028“行为科学家糖尿病研究职业发展计划（K12）”，鉴于目前 1 型糖尿病（T1D）研究中缺乏资深行为科学家来指导年轻研究人员，再加上贝勒医学院（BCM）儿科无与伦比的师资、研究和患者资源，我们热情地提交了这份指导行为科学家的提案BCM 儿童 1 型糖尿病 (T1D) 研究的职业发展。该职业发展计划的目的是为博士后和早期职业行为研究者[“学者”]创建一个跨学科和基于证据的计划。我们为 3 名学者（两名博士后级别和一名早期职业级别）提出了一个初步计划，他们将获得 2 至 3 年全面的、教学指导的 T1D 行为研究职业发展经验。该计划围绕三个目标建立：1) 学者必须了解青少年和家庭的 T1D“生活经历”，以促进临床知情的行为研究； 2) 学者们将了解 T1D 的神经生物学、血糖波动与行为之间的密切相互作用，以及神经认知风险和弹性因素如何影响行为、执行功能和依从性； 3) 学者将展示基本的资助写作技巧。该项目要求掌握 T1D 神经生物学的核心教学法和健康行为改变的理论/方法。根据学者之前的培训，教学法上有机会在附近的杰出学术机构（德克萨斯大学公共卫生学院和休斯顿大学）学习高级课程。学者们将接受由高级行为科学家和高级儿科内分泌学家组成的团队的指导，涉及以下 3 个研究途径之一：1）神经心理学和危险因素筛查； 2) 基于家庭和系统的干预措施，以优化血糖控制、依从性和生活质量结果，重点关注患有 T1D 的过渡年龄青少年； 3) 基于交互式技术的干预措施，以提高依从性和血糖控制。由贝勒大学高级教师组成的咨询委员会将评估该项目，并根据既定基准监控个别学者的进展。由资深科学家组成的外部顾问委员会也将提供反馈。我们的长期目标是创建一个全国认可的项目，培养在 T1D 行为研究领域取得成功并获得资助的科学家，他们最终将有能力继承行为糖尿病研究的指导遗产。

DESCRIPTION (provided by applicant): In response to RFA-DK-028 "Career Development Programs in Diabetes Research for Behavioral Scientists (K12)" and given that currently there is a documented lack of senior behavioral scientists in type 1 diabetes (T1D) research to mentor younger investigators, combined with the unparalleled faculty, research, and patient resources in Pediatrics at Baylor College of Medicine (BCM), we enthusiastically submit this proposal for Mentoring Behavioral Scientists for Career Development in Pediatric Type 1 Diabetes (T1D) Research at BCM. The purpose of this career development program is to create an interdisciplinary and evidence-based program for postdoctoral and early-career behavioral investigators ["Scholars"]. We propose an initial program for 3 Scholars (two postdoctoral level and one early career level) who will receive a 2-to 3-year comprehensive, didactic mentored career development experience in T1D behavioral research. The program is built around three objectives: 1) Scholars must understand the 'lived experience' of T1D for youth and families to foster clinically-informed behavioral research; 2) Scholars will understand the neuro-biology of T1D, the close interplay between blood glucose fluctuations and behavior, and how neurocognitive risk and resilience factors impact behavior, executive functioning, and adherence; and 3) Scholars will demonstrate basic grant writing skills. The program requires mastery of core didactics in neuro-biology of T1D and theories/methods of health behavior change. Depending on Scholars' prior training, mapped on to the didactics are opportunities for advanced courses at outstanding academic institutions nearby--the University of Texas School of Public Health and the University of Houston. Scholars will be mentored by a team of senior behavioral scientist and senior pediatric endocrinologist in 1 of 3 research pathways: 1) neuropsychology and risk-factor screening; 2) family- and systems-based interventions to optimize glycemic control, adherence and quality of life outcomes with a focus on transition-age youth with T1D; and 3) interactive technology-based interventions to improve adherence and glycemic control. An Advisory Committee of Senior Baylor faculty will evaluate the program and monitor the progress of the individual Scholars against established benchmarks. An External Advisory Board of senior scientists will also provide feedback. Our long-term goal is to create a nationally-recognized program that produces scientists with successful and funded careers in T1D behavioral research, who will eventually be well-positioned to carry on this legacy of mentoring in behavioral diabetes research.