Physiology and Pharmacology of BRS-3 (Bombesin Receptor Subtype-3)

作为我们研究BRS-3激动剂作用机制的一部分，我们有初步的数据表明BRS-3激动剂通过刺激棕色脂肪组织来提高代谢率。这些研究正在得到证实和扩展。我们也在研究BRS-3在血压控制中的作用。

As part of our studies to elucidate the mechanism of action of BRS-3 agonists, we have preliminary data that BRS-3 agonists increase metabolic rate via stimulating brown adipose tissue. These studies are being confirmed and expanded upon. We are also investigating the role fo BRS-3 in blood pressure control. In order to study the specific cells, sites, tissues, and transmitters by which BRS-3 acts, we are generating the following tools: 1) a conditional knockout floxed Brs3 mouse, 2) a knockin mouse with Cre recombinase driven by Brs3, and 3) a BAC transgenic mouse with Brs3 driving GFP expression. The long-term investment required to generate and validate these tools is expected to yield great rewards in future years. We are collaborating with Merck, using selective BRS-3 compounds (particularly the agonists MK-5046 and MK-7255). Additionally, work on BRS-3 that I was involved with at Merck Research Laboratories prior to my arrival at NIDDK continues to be guided through to publication.