Role of brown adipose tissue (BAT) in energy balance
Role of brown adipose tissue (BAT) in energy balance
批准号:
10919489
负责人:
MARC L REITMAN
金额:
$38.47万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
AcuteAdrenergic AgonistsAdultBiologyBody TemperatureBody WeightBrown FatDinitrophenolsEnergy MetabolismEnsureGenesGoalsHistamineHomeostasisHouse miceHumanInsulin ResistanceKnockout MiceMammalsModelingMusNeural PathwaysNeuronsObese MiceObesityPharmaceutical PreparationsPreoptic AreasProtonsRecoveryRegulationRoleTemperatureTissuescomorbidityenergy balanceexperimental studyinduced hypothermiainterestmetabolic ratenatural hypothermiareceptor
中文摘要
简介:
英文摘要
Summary:
Thermal biology is different between small and large mammals. At typical ambient environmental temperature (eg., 22 C), over one third of energy expenditure in mice is devoted to maintaining core body temperature, largely by brown adipose tissue (BAT). To conserve energy, mice can enter a regulated hypothermia, while humans do not. Since humans expend little or no energy specifically to keep warm, mice studied at 30 C (near thermoneutrality) may be a better model for human energy homeostasis. In mice, dinitrophenol, a protonophore, and CL316243, a beta3-adrenergic agonist, both increased metabolic rate at thermoneutrality but only CL316243 increased it at 22 C. Mice housed at 30 C also may become more obese than mice at 22 C. The effect of environmental temperature must be understood to ensure applicability of mouse experiments to human obesity.
BAT is also intimately involved with hypothermia, as induction of hypothermia involves complete inactivation of BAT, while recovery reactivates it. Thus, studies of drugs causing hypothermia should interact in the neural pathways that contribute to the regulation and control of BAT.
Progress in FY2023 includes the following:
We are continuing to study subpopulations of preoptic area neurons expressing BRS3 (POA-BRS3) neurons whose activation increased body temperature; inversely, acute inhibition of these neurons reduced body temperature. We have also begun to explore the role of histamine-1 receptors, encoded by the Hrh1 gene.
Another ongoing project is aimed at understanding the role of Otop1 (Otopetrin 1), a proton-selective channel that is highly expressed in brown adipose tissue. The main approach is comparison of wild-type and Otop1 knockout mice.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
REGULATION OF GENE EXPRESSION RELEVANT TO THE ADIPOSE CELL AND OBESITY
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批准号:6105566
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Physiology and Pharmacology of BRS-3 (Bombesin Receptor Subtype-3)
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批准号:8553647
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项目类别:
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资助金额:$69.66万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Studies in Youths & Young Adults with Obesity & T2DM (07-DK-0115, 10-DK-0163)
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批准号:8349793
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项目类别:
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资助金额:$57.65万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Physiology and Pharmacology of BRS3 (Bombesin-Like Receptor 3)
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批准号:10001930
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项目类别:
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资助金额:$123.98万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
What can body temperature tell us about energy homeostasis?
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批准号:10248173
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项目类别:
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资助金额:$38.0万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
What can body temperature tell us about energy homeostasis?
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批准号:10697821
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项目类别:
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资助金额:$40.63万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Physiology and Pharmacology of BRS-3 (Bombesin-Like Receptor 3)
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批准号:9356205
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项目类别:
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资助金额:$40.34万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
REGULATION OF GENE EXPRESSION RELEVANT TO THE ADIPOSE CELL AND OBESITY
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批准号:6289802
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Studies in Youths & Young Adults with Obesity & T2DM (07-DK-0115, 10-DK-0163)
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批准号:8553500
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项目类别:
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资助金额:$40.83万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Physiology and Pharmacology of BRS-3 (Bombesin Receptor Subtype-3)
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批准号:8741598
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项目类别:
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资助金额:$33.61万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Studies in Youths & Young Adults with Obesity & T2DM (07-DK-0115)
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批准号:8939596
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项目类别:
-
资助金额:$40.14万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Role of brown adipose tissue (BAT) in energy balance
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批准号:8939708
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项目类别:
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资助金额:$31.8万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Pharmacologic approaches to the treatment of obesity
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批准号:9549938
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项目类别:
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资助金额:$37.96万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Physiology and Pharmacology of BRS3 (Bombesin Receptor Subtype-3)
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批准号:10919485
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项目类别:
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资助金额:$38.47万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Role of brown adipose tissue (BAT) in energy balance
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批准号:10248174
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项目类别:
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资助金额:$38.0万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
What can body temperature tell us about energy homeostasis?
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批准号:9356208
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项目类别:
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资助金额:$40.34万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Secondary Prevention Trials For Recently Diagnosed Type 1 Diabetes Mellitus
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批准号:8349883
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项目类别:
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资助金额:$9.61万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Physiology and Pharmacology of BRS-3 (Bombesin Receptor Subtype-3)
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批准号:8349965
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项目类别:
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资助金额:$91.61万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
What can body temperature tell us about energy homeostasis?
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批准号:8741603
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项目类别:
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资助金额:$22.41万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
Role of brown adipose tissue (BAT) in energy balance
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批准号:8741604
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项目类别:
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资助金额:$28.01万
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财政年份:--
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负责人:MARC L REITMAN
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依托单位:
海外基金