Pediatric Artificial Pancreas System for Enhanced Diabetes Management in Young Children with Type 1 Diabetes
儿科人工胰腺系统可增强 1 型糖尿病幼儿的糖尿病管理
基本信息
- 批准号:9189931
- 负责人:
- 金额:$ 170.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-05-27 至 2019-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
PROJECT SUMMARY
Type 1 diabetes mellitus (T1D) management requires a significant effort by patients and their
families to maintain near-normal glycemia. The effort is magnified when patients are young
children. Recent technology development, integrated with advanced control design, has proven
effective for improving diabetes managements in adults. However, the design of a pediatric
artificial pancreas, focusing specifically on requirements of young children with T1D, and their
parents, is in early stages and not yet been thoroughly investigated. We will focus on the design
and clinical evaluation of a pediatric artificial pancreas system for enhanced diabetes
management in young children with T1D. The ultimate goal of the project is to develop, and
demonstrate in clinical studies, a safe and effective glucose management system that improves
glucose outcomes in young children with T1D, and improves parental quality of life.
Phase 1 - Development, refinement, and evaluation of pediatric glucose control strategy
– pediatric artificial pancreas: Insulin/Carbohydrate on Board (IOB/COB) models for young
children with T1D will be characterized and employed as safety mechanisms within a zone
Model Predictive Controller for automatic insulin delivery. The controller will undergo preliminary
clinical evaluation, with emphasis on assessing overnight and meal-time glucose control.
Phase 2 - Design and evaluation of parental oriented remote advisory and glucose
supervision system for open and closed-loop glucose control: We will engineer a parental
remote supervision and alert system to reduce the risk of hypoglycemia, and the fear of
nocturnal hypoglycemia, and develop adaptive advisory algorithms for glucose control, thereby
improving insulin management by parents of young children with T1D. The alert and advisory
system will be evaluated in a series of CRC and ambulatory clinical trials for safety and efficacy,
as well for its effects on mitigating parental stress and anxiety.
Phase 3 – Reduction of nocturnal hypoglycemia events and parental stress and
improvement in glycemic control in ambulatory settings: The integrated system will be
validated in a pilot clinical trial prior to deployment into practice, and contrasted, by a
randomized crossover trial, with the state-of-the-art therapy; sensor augmented pump (SAP) or
threshold suspend (TS) technology. The hypothesis of phase 3 is: Compared to SAP or TS,
combining a pediatric AP and safety system reduces the hypoglycemia risk and lengthens time
spent in the range 70-180 mg/dL, without compromising average glycemic control. Secondary
outcomes include the system's effect on parental stress, anxiety, and fear of hypoglycemia.
项目摘要
1型糖尿病(T1 D)的管理需要患者及其家属做出巨大努力。
家庭保持正常的生活。当患者年轻时,
孩子最近的技术发展,结合先进的控制设计,已经证明,
有效改善成人糖尿病管理。然而,儿科的设计
人工胰腺,特别关注T1 D幼儿的需求,
父母,处于早期阶段,尚未进行彻底调查。我们将专注于设计
小儿人工胰腺系统治疗糖尿病的临床评价
治疗T1 D儿童。该项目的最终目标是发展,
在临床研究中证明,一种安全有效的葡萄糖管理系统,
T1 D患儿的血糖结果,并改善父母的生活质量。
第1阶段-儿科血糖控制策略的开发、完善和评价
- 小儿人工胰腺:适用于年轻人的胰岛素/碳水化合物(IOB/COB)模型
患有T1 D的儿童将被定性并用作区域内的安全机制
用于自动胰岛素输注的模型预测控制器。控制器将进行初步
临床评价,重点是评估夜间和餐时血糖控制。
第2阶段-面向父母的远程咨询和血糖监测的设计和评价
开环和闭环葡萄糖控制的监督系统:我们将设计一个父母
远程监控和警报系统,以减少低血糖的风险,
夜间低血糖,并开发自适应血糖控制咨询算法,从而
改善T1 D幼儿父母的胰岛素管理。警报和咨询
将在一系列CRC和门诊临床试验中评估系统的安全性和有效性,
以及减轻父母压力和焦虑的效果。
3期-减少夜间低血糖事件和父母压力,
改善门诊环境中的血糖控制:集成系统将
在部署到实践中之前,在试点临床试验中进行了验证,并通过
随机交叉试验,采用最先进的治疗;传感器增强泵(SAP)或
阈值暂停(TS)技术。第3阶段的假设是:与SAP或TS相比,
结合儿科AP和安全系统可降低低血糖风险,
在70-180 mg/dL的范围内消耗,而不影响平均血糖控制。二次
结果包括该系统对父母压力、焦虑和低血糖恐惧的影响。
项目成果
期刊论文数量(19)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(2)
Minority groups and the artificial pancreas: who is (not) in line?
少数群体和人工胰腺:谁(不)排队?
- DOI:10.1016/s2213-8587(16)30144-9
- 发表时间:2016
- 期刊:
- 影响因子:0
- 作者:Huyett,Lauren;Dassau,Eyal;Pinsker,JordanE;Doyle3rd,FrancisJ;Kerr,David
- 通讯作者:Kerr,David
A Personalized Week-to-Week Updating Algorithm to Improve Continuous Glucose Monitoring Performance.
个性化的每周更新算法,以提高连续血糖监测性能。
- DOI:10.1177/1932296817734367
- 发表时间:2017
- 期刊:
- 影响因子:5
- 作者:Zavitsanou,Stamatina;Lee,JoonBok;Pinsker,JordanE;Church,MeiMei;Doyle3rd,FrancisJ;Dassau,Eyal
- 通讯作者:Dassau,Eyal
Outpatient Randomized Crossover Automated Insulin Delivery Versus Conventional Therapy with Induced Stress Challenges.
门诊随机交叉自动胰岛素输送与诱导应激挑战的传统疗法。
- DOI:10.1089/dia.2021.0436
- 发表时间:2022
- 期刊:
- 影响因子:5.4
- 作者:Kaur,RavinderJeet;Deshpande,Sunil;Pinsker,JordanE;Gilliam,WesleyP;McCrady-Spitzer,Shelly;Zaniletti,Isabella;Desjardins,Donna;Church,MeiMei;DoyleIii,FrancisJ;Kremers,WalterK;Dassau,Eyal;Kudva,YogishC
- 通讯作者:Kudva,YogishC
Enhanced Model Predictive Control (eMPC) Strategy for Automated Glucose Control.
- DOI:10.1021/acs.iecr.6b02718
- 发表时间:2016-11-23
- 期刊:
- 影响因子:4.2
- 作者:Lee, Joon Bok;Dassau, Eyal;Gondhalekar, Ravi;Seborg, Dale E.;Pinsker, Jordan E.;Doyle, Francis J., III
- 通讯作者:Doyle, Francis J., III
Embedded Model Predictive Control for a Wearable Artificial Pancreas.
- DOI:10.1109/tcst.2019.2939122
- 发表时间:2020-11
- 期刊:
- 影响因子:0
- 作者:Chakrabarty A;Healey E;Shi D;Zavitsanou S;Doyle FJ 3rd;Dassau E
- 通讯作者:Dassau E
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
FRANCIS J DOYLE其他文献
FRANCIS J DOYLE的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('FRANCIS J DOYLE', 18)}}的其他基金
MECHANISMS AND MODELING OF NETWORKED CIRCADIAN PACEMAKER SYNCHRONIZATION
网络化昼夜节律起搏器同步的机制和建模
- 批准号:
8515466 - 财政年份:2011
- 资助金额:
$ 170.97万 - 项目类别:
MECHANISMS AND MODELING OF NETWORKED CIRCADIAN PACEMAKER SYNCHRONIZATION
网络化昼夜节律起搏器同步的机制和建模
- 批准号:
8710258 - 财政年份:2011
- 资助金额:
$ 170.97万 - 项目类别:
MECHANISMS AND MODELING OF NETWORKED CIRCADIAN PACEMAKER SYNCHRONIZATION
网络化昼夜节律起搏器同步的机制和建模
- 批准号:
8049511 - 财政年份:2011
- 资助金额:
$ 170.97万 - 项目类别:
MECHANISMS AND MODELING OF NETWORKED CIRCADIAN PACEMAKER SYNCHRONIZATION
网络化昼夜节律起搏器同步的机制和建模
- 批准号:
8309142 - 财政年份:2011
- 资助金额:
$ 170.97万 - 项目类别:
Closed-loop Artificial Pancreas: Algorithm Engineering and Clinical Evaluation
闭环人工胰腺:算法工程和临床评估
- 批准号:
8531230 - 财政年份:2009
- 资助金额:
$ 170.97万 - 项目类别:
Closed-loop Artificial Pancreas: Algorithm Engineering and Clinical Evaluation
闭环人工胰腺:算法工程和临床评估
- 批准号:
8326148 - 财政年份:2009
- 资助金额:
$ 170.97万 - 项目类别:
Closed-loop Artificial Pancreas: Algorithm Engineering and Clinical Evaluation
闭环人工胰腺:算法工程和临床评估
- 批准号:
7939714 - 财政年份:2009
- 资助金额:
$ 170.97万 - 项目类别:
Closed-loop Artificial Pancreas: Algorithm Engineering and Clinical Evaluation
闭环人工胰腺:算法工程和临床评估
- 批准号:
8137201 - 财政年份:2009
- 资助金额:
$ 170.97万 - 项目类别:
Closed-loop Artificial Pancreas: Algorithm Engineering and Clinical Evaluation
闭环人工胰腺:算法工程和临床评估
- 批准号:
7792135 - 财政年份:2009
- 资助金额:
$ 170.97万 - 项目类别:
a Run-to-Run Algorithm for Glucose Regulation
用于葡萄糖调节的逐次运行算法
- 批准号:
6827019 - 财政年份:2004
- 资助金额:
$ 170.97万 - 项目类别:
相似海外基金
Quantifying Artificial Pancreas-related Changes in Diabetic Neuropathy
量化糖尿病神经病变中人工胰腺相关的变化
- 批准号:
MR/W030071/1 - 财政年份:2023
- 资助金额:
$ 170.97万 - 项目类别:
Research Grant
SenSE: Closed-loop Artificial Pancreas with Noninvasive Monitoring of Glucose and Diet
SenSE:可无创监测血糖和饮食的闭环人工胰腺
- 批准号:
2322879 - 财政年份:2022
- 资助金额:
$ 170.97万 - 项目类别:
Standard Grant
Co-administration of pramlintide and insulin via an automated dual hormone artificial pancreas system to regulate glucose levels in adults with type 1 diabetes
通过自动双激素人工胰腺系统联合施用普兰林肽和胰岛素来调节成人 1 型糖尿病患者的血糖水平
- 批准号:
500273 - 财政年份:2022
- 资助金额:
$ 170.97万 - 项目类别:
Studentship Programs
Advanced Artificial Pancreas Systems to Enable Fully Automated Glycemic Control in Type 1 Diabetes Mellitus
先进的人工胰腺系统可实现 1 型糖尿病的全自动血糖控制
- 批准号:
10676903 - 财政年份:2021
- 资助金额:
$ 170.97万 - 项目类别:
Multivariable Artificial Pancreas System to Detect and Mitigate the Effects of Unannounced Physical Activities and Acute Psychological Stress
多变量人工胰腺系统可检测和减轻未经通知的体力活动和急性心理压力的影响
- 批准号:
10488195 - 财政年份:2021
- 资助金额:
$ 170.97万 - 项目类别:
Advanced Artificial Pancreas Systems to Enable Fully Automated Glycemic Control in Type 1 Diabetes Mellitus
先进的人工胰腺系统可实现 1 型糖尿病的全自动血糖控制
- 批准号:
10276560 - 财政年份:2021
- 资助金额:
$ 170.97万 - 项目类别:
Advanced Artificial Pancreas Systems to Enable Fully Automated Glycemic Control in Type 1 Diabetes Mellitus
先进的人工胰腺系统可实现 1 型糖尿病的全自动血糖控制
- 批准号:
10488207 - 财政年份:2021
- 资助金额:
$ 170.97万 - 项目类别:
Analysis of glycemic metabolism and exploration of novel therapy for surgical patients with sarcopenia using an artificial pancreas
人工胰腺外科手术患者的血糖代谢分析及新疗法探索
- 批准号:
21K12647 - 财政年份:2021
- 资助金额:
$ 170.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A randomized, controlled, pilot, crossover trial to assess a fully automated, dual-hormone (insulin-pramlintide) artificial pancreas without carbohydrate counting in regulating glucose levels in adults with type 1 diabetes.
一项随机、对照、试点、交叉试验,旨在评估全自动双激素(胰岛素-普兰林肽)人工胰腺(无需碳水化合物计数)在调节 1 型糖尿病成人血糖水平方面的作用。
- 批准号:
466655 - 财政年份:2021
- 资助金额:
$ 170.97万 - 项目类别:
Studentship Programs
Multivariable Artificial Pancreas System to Detect and Mitigate the Effects of Unannounced Physical Activities and Acute Psychological Stress
多变量人工胰腺系统可检测和减轻未经通知的体力活动和急性心理压力的影响
- 批准号:
10290033 - 财政年份:2021
- 资助金额:
$ 170.97万 - 项目类别: