Modulation of cortical processing by engagement with the sensory environment
通过与感觉环境的接触来调节皮质处理
基本信息
- 批准号:8650124
- 负责人:
- 金额:$ 2.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-04-01 至 2014-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAnterolateralAttentionAttention deficit hyperactivity disorderBehaviorBehavioralBiological ModelsCellsCodeCognition DisordersDendritesDependovirusDevelopmentDextransDiscriminationDyesEnvironmentEquilibriumFunctional disorderGeneticGoalsHeadHistologyImageIndividualInformation TheoryInterneuronsLabelMeasuresMicroscopeMonitorMusNeocortexNeuronsParvalbuminsPerformancePhysiologyPopulationPositioning AttributePreparationProcessProteinsRelative (related person)ResearchResearch PersonnelScanningSensorySensory ProcessSomatostatinSpeedStructureStudentsTask PerformancesTestingTherapeuticTracerTransgenic MiceV1 neuronVisualVisual CortexWorkarea V1area striataawakebehavior influenceblindcalcium indicatorcell typedextranextrastriateextrastriate visual corteximprovedinterestmouse modelnervous system disorderoptogeneticspromoterpublic health relevancered fluorescent proteinrelating to nervous systemresearch studyresponsesensory cortextwo-photonvisual processvisual processingvisual stimulus
项目摘要
DESCRIPTION (provided by applicant): Two individuals presented with similar sensory input may process the incoming material in very different ways depending on their level of engagement with the presented information. However, it is not understood how engagement (defined as non-selective attention to sensory input) exerts such a strong influence on neural processing. The goal of the proposed research is to investigate the influence of engagement on cortical processing of visual input using a mouse model. First, we will establish an experimental preparation for measuring the activity of primary visual cortical (V1) neurons in awake, head-fixed mice performing a behavioral task (Aim 1). Neural activity will be measured by 2-photon imaging of visual cortical neurons expressing a virally delivered genetically encoded calcium indicator (GCaMP5) while the mouse performs a demanding orientation discrimination task. The response apparatus will be withdrawn in alternating blocks, allowing comparison of responses during engaged versus passive viewing. Next, we will characterize the effects of engagement on different classes of neurons in V1 using transgenic mouse lines that express red fluorescent protein (TdTomato) in cell types of interest (specifically, parvalbumin-positive and somatostatin- positive interneurons; Aim 2). Genetic identification of interneuron subtypes will allow us to dissect the effect of engagement on specific components of the cortical circuitry. Finally, we will
investigate the impact of engagement on sensory processing in higher visual cortical regions beyond V1 (Aim 3). For these experiments, secondary visual areas LM (lateromedial), AL (anterolateral), and PM (posteromedial) will be identified using anterograde tracers and imaged using GCaMP5. Responses in secondary visual areas will be imaged to determine whether engagement enhances the propagation of sensory information more broadly throughout the visual cortical hierarchy. Taken together, this work will have important implications for understanding the influence of behavioral engagement on sensory processing in the neocortex, and reveal fundamental mechanisms underlying disorders of cognition that afflict engagement and attention.
描述(由申请人提供):两个人呈现相似的感官输入可能会以非常不同的方式处理传入的材料,这取决于他们对所呈现信息的参与程度。然而,目前还不清楚参与(定义为对感官输入的非选择性注意)如何对神经处理产生如此强烈的影响。该研究的目的是利用小鼠模型研究参与对视觉输入皮层处理的影响。首先,我们将建立一个实验准备测量活动的初级视觉皮层(V1)神经元在清醒的,头部固定的小鼠执行行为任务(目标1)。神经活动将通过表达病毒递送的遗传编码钙指示剂(GCaMP 5)的视觉皮层神经元的双光子成像来测量,同时小鼠执行要求严格的方向辨别任务。反应装置将在交替的区块中被撤回,允许在参与与被动观看期间的反应进行比较。接下来,我们将使用在感兴趣的细胞类型中表达红色荧光蛋白(TdTomato)的转基因小鼠系(特别是小清蛋白阳性和生长抑素阳性中间神经元;目标2)来表征参与对V1中不同类别神经元的影响。对中间神经元亚型的遗传鉴定将使我们能够剖析参与对皮质回路特定组件的影响。最后我们将
研究参与对V1以外的高级视觉皮层区域感觉处理的影响(目标3)。对于这些实验,将使用顺行示踪剂识别次级视觉区域LM(外侧)、AL(前外侧)和PM(后内侧),并使用GCaMP 5成像。将对次级视觉区的反应进行成像,以确定参与是否能更广泛地增强感觉信息在整个视觉皮层层次中的传播。总之,这项工作将对理解行为参与对新皮层感觉处理的影响具有重要意义,并揭示影响参与和注意力的认知障碍的基本机制。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
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Michael Goard其他文献
Michael Goard的其他文献
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{{ truncateString('Michael Goard', 18)}}的其他基金
Dissection of the neural circuitry of short-term memory in behaving mice
行为小鼠短期记忆神经回路的剖析
- 批准号:
9177784 - 财政年份:2016
- 资助金额:
$ 2.03万 - 项目类别:
Dissection of the neural circuitry of short-term memory in behaving mice
行为小鼠短期记忆神经回路的剖析
- 批准号:
9220851 - 财政年份:2016
- 资助金额:
$ 2.03万 - 项目类别:
Dissection of the neural circuitry of short-term memory in behaving mice
行为小鼠短期记忆神经回路的剖析
- 批准号:
8750984 - 财政年份:2014
- 资助金额:
$ 2.03万 - 项目类别:
Modulation of cortical processing by engagement with the sensory environment
通过与感觉环境的接触来调节皮质处理
- 批准号:
8526737 - 财政年份:2013
- 资助金额:
$ 2.03万 - 项目类别:
Cholinergic Modulation of Visual Cortical Processing
视觉皮层处理的胆碱能调节
- 批准号:
7662429 - 财政年份:2008
- 资助金额:
$ 2.03万 - 项目类别:
Cholinergic Modulation of Visual Cortical Processing
视觉皮层处理的胆碱能调节
- 批准号:
7546679 - 财政年份:2008
- 资助金额:
$ 2.03万 - 项目类别:
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