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Integrating Statistical Imputation of HLA and KIR Alleles into Studies of Disease in Diverse Human Populations

Integrating Statistical Imputation of HLA and KIR Alleles into Studies of Disease in Diverse Human Populations
将 HLA 和 KIR 等位基因的统计插补纳入不同人群的疾病研究
批准号：
nhmrc : 1053756
负责人：
A/Pr Stephen Leslie
金额：
$27.69万
依托单位：
The University of Melbourne
依托单位国家：
澳大利亚
项目类别：
Career Development Fellowships
财政年份：
2013
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2013-01-01 至 2016-12-31
来源：
https://researchdata.edu.au/integrating-statistical-imputation-human-populations/112344
关键词：
IntegratingStatisticalImputationHLAKIR

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英文摘要
Immune system genes are strongly implicated in many infectious and autoimmune diseases, as well as cancer. Some of these genes have many possible types due to natural selection in response to pathogens. This variability makes typing these genes very expensive. Developing accurate and inexpensive methods to type these genes is vital in understanding the role they play in susceptibility and progression of disease and will be important for the development of better diagnostic tests and treatments.
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Constructing control samples for the Australian and other populations: improving power and false positive rates in the next generation of genetic association studies with a focus on controlling for fine-scale population structure in DNA sequence data
  • 批准号：
    nhmrc : 1070884
  • 项目类别：
    Project Grants
  • 资助金额：
    $18.9万
  • 财政年份：
    2014
  • 负责人：
    A/Pr Stephen Leslie
  • 依托单位：
    The University of Melbourne
Methods for increasing the accuracy and efficiency of population based studies of the association between genes and disease
  • 批准号：
    nhmrc : GNT1070884
  • 项目类别：
    Project Grants
  • 资助金额：
    $18.14万
  • 财政年份：
    2014
  • 负责人：
    A/Pr Stephen Leslie
  • 依托单位：
    The University of Melbourne
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