Integrating Statistical Imputation of HLA and KIR Alleles into Studies of Disease in Diverse Human Populations

将 HLA 和 KIR 等位基因的统计插补纳入不同人群的疾病研究

• 批准号: nhmrc : 1053756
• 负责人: A/Pr Stephen Leslie
• 金额: $ 27.69万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/integrating-statistical-imputation-human-populations/112344
• 关键词: Integrating; Statistical; Imputation; HLA; KIR

Immune system genes are strongly implicated in many infectious and autoimmune diseases, as well as cancer. Some of these genes have many possible types due to natural selection in response to pathogens. This variability makes typing these genes very expensive. Developing accurate and inexpensive methods to type these genes is vital in understanding the role they play in susceptibility and progression of disease and will be important for the development of better diagnostic tests and treatments.

免疫系统基因与许多传染性和自身免疫性疾病以及癌症密切相关。由于对病原体的自然选择，其中一些基因有许多可能的类型。这种可变性使得这些基因的分型非常昂贵。开发准确和廉价的方法对这些基因进行分型，对于了解它们在疾病易感性和进展中所起的作用至关重要，对于开发更好的诊断测试和治疗方法也很重要。