Constructing control samples for the Australian and other populations: improving power and false positive rates in the next generation of genetic association studies with a focus on controlling for fine-scale population structure in DNA sequence data

为澳大利亚和其他人群构建控制样本：提高下一代遗传关联研究的功效和假阳性率，重点是控制 DNA 序列数据中的精细人群结构

• 批准号: nhmrc : 1070884
• 负责人: A/Pr Stephen Leslie
• 金额: $ 18.9万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/constructing-control-samples-dna-sequence/455446
• 关键词: Constructing; control; samples; Australian; other

Individuals who live near each other tend to be more similar genetically than individuals who live in different parts of the world. One reason is that they share more of their genetic ancestry. There can be very subtle differences in patterns of genetic variation even within countries. Accounting for these subtle differences can be important for studies of the genetic basis of diseases. We will develop novel statistical methods to control for these genetic differences in disease studies.

生活在一起的个体在基因上往往比生活在世界不同地方的个体更相似。原因之一是他们有更多的遗传祖先。即使在国家内部，遗传变异的模式也可能存在非常微妙的差异。解释这些细微的差异对于研究疾病的遗传基础是很重要的。我们将开发新的统计方法来控制疾病研究中的这些遗传差异。