Constructing control samples for the Australian and other populations: improving power and false positive rates in the next generation of genetic association studies with a focus on controlling for fine-scale population structure in DNA sequence data

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Individuals who live near each other tend to be more similar genetically than individuals who live in different parts of the world. One reason is that they share more of their genetic ancestry. There can be very subtle differences in patterns of genetic variation even within countries. Accounting for these subtle differences can be important for studies of the genetic basis of diseases. We will develop novel statistical methods to control for these genetic differences in disease studies.