Methods for increasing the accuracy and efficiency of population based studies of the association between genes and disease

提高基于人群的基因与疾病关联研究的准确性和效率的方法

• 批准号: nhmrc : GNT1070884
• 负责人: A/Pr Stephen Leslie
• 金额: $ 18.14万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/methods-increasing-accuracy-genes-disease/1344997
• 关键词: Methods; increasing; accuracy; efficiency; population

Individuals who live near each other tend to be more similar genetically than individuals who live in different parts of the world. One reason is that they share more of their genetic ancestry. There can be very subtle differences in patterns of genetic variation even within countries. Accounting for these subtle differences can be important for studies of the genetic basis of diseases. We will develop novel statistical methods to control for these genetic differences in disease studies.

生活在一起的个体在基因上往往比生活在世界不同地方的个体更相似。原因之一是他们有更多的遗传祖先。即使在国家内部，遗传变异的模式也可能存在非常微妙的差异。解释这些细微的差异对于研究疾病的遗传基础是很重要的。我们将开发新的统计方法来控制疾病研究中的这些遗传差异。