Methods for increasing the accuracy and efficiency of population based studies of the association between genes and disease
Methods for increasing the accuracy and efficiency of population based studies of the association between genes and disease
批准号:
nhmrc : GNT1070884
负责人:
A/Pr Stephen Leslie
金额:
$18.14万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31
中文摘要
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英文摘要
Individuals who live near each other tend to be more similar genetically than individuals who live in different parts of the world. One reason is that they share more of their genetic ancestry. There can be very subtle differences in patterns of genetic variation even within countries. Accounting for these subtle differences can be important for studies of the genetic basis of diseases. We will develop novel statistical methods to control for these genetic differences in disease studies.
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会议论文
Constructing control samples for the Australian and other populations: improving power and false positive rates in the next generation of genetic association studies with a focus on controlling for fine-scale population structure in DNA sequence data
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批准号:nhmrc : 1070884
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项目类别:Project Grants
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资助金额:$18.9万
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财政年份:2014
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负责人:A/Pr Stephen Leslie
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依托单位:
Integrating Statistical Imputation of HLA and KIR Alleles into Studies of Disease in Diverse Human Populations
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批准号:nhmrc : 1053756
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项目类别:Career Development Fellowships
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资助金额:$27.69万
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财政年份:2013
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负责人:A/Pr Stephen Leslie
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依托单位:
海外基金