Integrating treatment for alcohol use problems and comorbid PTSD

酒精使用问题和共病创伤后应激障碍 (PTSD) 的综合治疗

• 批准号: nhmrc : 455221
• 负责人: A/Pr Katherine Mills
• 金额: $ 43.88万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/integrating-treatment-alcohol-comorbid-ptsd/101139
• 关键词: Integrating; treatment; alcohol; use; problems

Comorbid alcohol use problems and posttraumatic stress disorder (PTSD) are common mental health problems that cause disability and distress. Despite this, there are few randomized controlled trials of interventions. The proposed study is the first Australian randomised controlled trial in this field to address the question of whether treating PTSD and alcohol use problems is superior to treating alcohol use problems alone. The study compares the relative efficacy of a manual guided treatment for alcohol use disorder alone with a simultaneous treatment for alcohol use and PTSD. This study improves on the methodological limitations described in the two existing studies reported in the published literature. Two-hundred and sixty four participants will be recruited from mutiple sites (media, GPs, specialist clinics) and treated in the community at two sites in Sydney. Participants will be eligible if they consume harmful levels of alcohol (NHMRC risky or high risk levels) and have a concurrent diagnosis of PTSD based on recognised diagnostic criteria. Treatment will consist of 16 sessions of manual guided individual psychological therapy that has been found to be very efficacious with each problem alone. The efficacy of treatment will be determined on the basis of reductions in harmful drinking (above NHMRC low risk levels) and in symptoms of PTSD. Participants will be followed up by an independent, blind, clinician three and six months after treatment completion. The findings of this study have the potential to provide valuable information regarding the treatment needs of people with these complex presentations to clinicians and policy developers alike.

共病的酒精使用问题和创伤后应激障碍（PTSD）是常见的心理健康问题，导致残疾和痛苦。尽管如此，很少有干预措施的随机对照试验。这项研究是澳大利亚在这一领域的第一项随机对照试验，旨在解决治疗创伤后应激障碍和酒精使用问题是否优于单独治疗酒精使用问题的问题。该研究比较了单独使用酒精使用障碍的手动指导治疗与同时治疗酒精使用和创伤后应激障碍的相对疗效。本研究改进了已发表文献中报告的两项现有研究中描述的方法学局限性。将从多个研究中心（媒体、全科医生、专科诊所）招募264名参与者，并在悉尼的两个研究中心的社区接受治疗。参与者将有资格，如果他们消耗有害水平的酒精（NHMRC风险或高风险水平），并有基于公认的诊断标准的创伤后应激障碍的并发诊断。治疗将包括16个疗程的手动指导个人心理治疗，已被发现是非常有效的每一个问题。治疗的有效性将根据有害饮酒（高于NHMRC低风险水平）和PTSD症状的减少来确定。参与者将在治疗完成后3个月和6个月由独立的盲法临床医生进行随访。这项研究的结果有可能为临床医生和政策制定者提供有关这些复杂表现的人的治疗需求的有价值的信息。