Molecular Microbiology Training Grant

德克萨斯大学西南医学中心（UTSW）是世界上首屈一指的学术医学中心之一，要求继续支持已经存在15年的研究生和研究生分子微生物学培训计划（MMTP）。这个非常成功的培训计划的一个特别吸引人的特点是它从传统的“计划”或“基于部门”的培训转向跨学科的计划，该计划保持了很强的微生物学方向， 同时，扩大了培训使命的范围，使之包括分子和细胞生物学的许多其他方面。26名培训师的高度多样化的背景，包括一个高度成就的研究人员和一个不断扩大的，令人印象深刻的新教师的核心小组，体现了由分子和细胞微生物学的共同主题约束的跨学科研究计划。培训教师来自10个不同的部门/中心（微生物学，免疫学，生理学，内科/传染病，综合癌症中心，细胞生物学，分子生物学，药理学，生物化学和儿科）。MMTP作为一个主要的焦点，在这个重叠的人才培训师谁在研究和培训的成就有很强的记录之间的正式互动。我们的目标是培养学生和研究员在微生物发病机制的分子基础，细胞微生物学，宿主防御机制，疫苗开发，毒力表达调控，病原体适应，药物开发，结构生物学和许多其他相关领域的一般领域的研究事业。大多数教师的研究兴趣包括但不限于细菌和病毒的发病机制，微生物毒素，群体 生物学领域的研究领域包括：免疫系统、免疫原性有一个强烈的强调分子机制，分子生物学，和最现代的方法在分子技术中的应用（例如，结构生物学、生物化学和分子生物物理学），所有这些都提供了将不同研究领域联合和整合的线索。完成该计划的学员预计将能够应用最先进的分子方法来解决微生物科学中的重要问题，并改善传染病的预防和/或治疗干预策略。有确凿的证据表明，在过去的供资期间，这一培训方案取得了重大成功。

DESCRIPTION (provided by applicant): The University of Texas Southwestern Medical Center (UTSW), one of the premier academic medical centers in the world, requests continued support for a graduate and post-graduate Molecular Microbiology Training Program (MMTP) that has been extant for 15 years. A particularly attractive feature of this highly successful training program has been its departure from conventional "program-" or "departmental-based" training to an interdisciplinary program that maintains a strong microbiology orientation while, at the same time, broadens the scope of the training mission to include many other aspects of molecular and cell biology. The highly diverse backgrounds of the 26 trainers, comprised of a core group of highly accomplished established investigators and an expanding, impressive new faculty, embody interdisciplinary research programs bound by the common theme of molecular and cellular microbiology. The training faculty emanate from 10 different departments/centers (Microbiology, Immunology, Physiology, Internal Medicine/Infectious Diseases, Comprehensive Cancer Center, Cell Biology, Molecular Biology, Pharmacology, Biochemistry, and Pediatrics). The MMTP serves as a primary focus for formal interactions among this overlapping group of talented trainers who have strong records of accomplishment in research and training. Our goal is to train students and fellows for research careers in the general areas of the molecular basis of microbial pathogenesis, cellular microbiology, host defense mechanisms, vaccine development, regulation of virulence expression, pathogen adaptation, drug development, structural biology, and many other related areas. The research interests of the majority of the faculty include, but are not limited to, bacterial and viral pathogenesis, microbial toxins, quorum sensing, innate and adaptive immune mechanisms, antimicrobial drug design, small molecule inhibitors for viruses and bacteria, autophagy, cancer chemotherapy, RNA metabolism in viral life cycles, bacterial type III secretion systems and effectors, prokaryotic membrane biology, contemporary approaches to vaccine development, translational science, microbial physiology, and structural biology. There is a strong emphasis on molecular mechanisms, molecular biology, and the application of the most contemporary methods in molecular technologies (e.g., structural biology, biochemistry, and molecular biophysics), all of which provide the thread that unites and integrates the diverse research areas. Trainees who complete this program are expected to be able to apply state-of-the-art molecular approaches towards important problems in the microbiological sciences and for the improvement of preventive and/or therapeutic intervention strategies for infectious diseases. There is solid evidence of major successes for this training program over the past funding interval.