Molecular Microbiology Training Grant

项目摘要/摘要 德克萨斯大学西南医学中心(UTSW)，领先的学术医学中心之一 世界上的分子微生物学中心，要求继续支持研究生和研究生分子微生物学 已经存在了20年的培训计划(MMTP)。这项MMTP支持五名博士后学生和 两名博士后研究员，每人为期两年的训练期。它的一个特别吸引人的特点是高度 成功的培训计划是它脱离了传统的“计划”或“以部门为基础” 对跨学科项目的培训，该项目保持强烈的微生物学方向，同时， 扩大培训任务的范围，将分子和细胞生物学的许多其他方面包括在内。这个 28名培训员的背景非常不同，由一组非常有成就的 研究人员和不断扩大的、令人印象深刻的新教师队伍，体现了受 分子和细胞微生物学的共同主题。培训人员来自10个不同的 科室/中心(微生物学、免疫学、生理学、内科/传染病、 综合癌症中心、细胞生物学、分子生物学、药理学、生物化学和儿科学)。 MMTP是这群有才华的培训师之间正式互动的主要焦点 他们在研究和培训方面有很强的成就记录。我们的目标是培养学生和研究员 在微生物发病的分子基础的一般领域的研究生涯，细胞 微生物学，寄主防御机制，疫苗开发，毒力表达调控，病原体 适应、药物开发、结构生物学和许多其他相关领域。该中心的研究兴趣 大多数教员包括细菌和病毒致病机制、微生物毒素、群体感应、先天和 适应性免疫机制、抗菌药物设计、自噬、肿瘤发生、RNA代谢、细菌 III型分泌系统，疫苗开发，翻译科学，微生物生理学，病毒进化， 和结构生物学(因为它与微生物发病机制有关)。对分子的重视程度很高 机制、分子生物学和最新方法在分子科学中的应用 技术(例如，结构生物学、生物化学和分子生物物理学)，所有这些都提供了线索 它统一和整合了不同的研究领域。完成这一计划的受训者预计将是 能够将最先进的分子方法应用于微生物学中的重要问题 以及改进传染病的预防和/或治疗干预战略。那里 是这一培训计划在过去的资助期间取得重大成功的确凿证据。

PROJECT SUMMARY/ABSTRACT The University of Texas Southwestern Medical Center (UTSW), one of the premier academic medical centers in the world, requests continued support for a graduate and post-graduate Molecular Microbiology Training Program (MMTP) that has existed for 20 years. This MMTP supports five predoctoral students and two postdoctoral fellows for two-year training periods each. A particularly attractive feature of this highly successful training program has been its departure from conventional "program-" or "departmental-based" training to an interdisciplinary program that maintains a strong microbiology orientation while, at the same time, broadens the scope of the training mission to include many other aspects of molecular and cell biology. The highly diverse backgrounds of the 28 trainers, comprised of a core group of highly accomplished established investigators and an expanding, impressive new faculty, embody interdisciplinary research programs bound by the common theme of molecular and cellular microbiology. The training faculty emanate from 10 different departments/centers (Microbiology, Immunology, Physiology, Internal Medicine/Infectious Diseases, Comprehensive Cancer Center, Cell Biology, Molecular Biology, Pharmacology, Biochemistry, and Pediatrics). The MMTP serves as a primary focus for formal interactions among this overlapping group of talented trainers who have strong records of accomplishment in research and training. Our goal is to train students and fellows for research careers in the general areas of the molecular basis of microbial pathogenesis, cellular microbiology, host defense mechanisms, vaccine development, regulation of virulence expression, pathogen adaptation, drug development, structural biology, and many other related areas. The research interests of the majority of the faculty include bacterial and viral pathogenesis, microbial toxins, quorum sensing, innate and adaptive immune mechanisms, antimicrobial drug design, autophagy, oncogenesis, RNA metabolism, bacterial type III secretion systems, vaccine development, translational science, microbial physiology, viral evolution, and structural biology (as it pertains to microbial pathogenesis). There is a strong emphasis on molecular mechanisms, molecular biology, and the application of the most contemporary methods in molecular technologies (e.g., structural biology, biochemistry, and molecular biophysics), all of which provide the thread that unites and integrates the diverse research areas. Trainees who complete this program are expected to be able to apply state-of-the-art molecular approaches towards important problems in the microbiological sciences and for the improvement of preventive and/or therapeutic intervention strategies for infectious diseases. There is solid evidence of major successes for this training program over the past funding interval.