Integrating Wnt-Apc pathway with TGF-beta signalling in colon cancer

结肠癌中 Wnt-Apc 通路与 TGF-β 信号传导的整合

• 批准号: nhmrc : 628727
• 负责人: Dr Hong-Jian Zhu
• 金额: $ 22.83万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/integrating-wnt-apc-colon-cancer/76108
• 关键词: Integrating; Wnt; Apc; pathway; TGF

Colon cancer is one of the leading causes of death of all cancers. Two molecular pathways have been independently implicated in colon cancer development. Emerging evidences suggest that the two pathways may work together in the colon polypus formation. This application will integrate two separate molecular causes to form a new coherent understanding of cancer development and offer new directions in development of novel colon cancer treatment.

结肠癌是所有癌症死亡的主要原因之一。两条分子途径独立地涉及结肠癌的发展。新的证据表明，这两种途径可能在结肠息肉形成中共同作用。该应用将整合两个不同的分子原因，形成对癌症发展的新的连贯理解，并为新型结肠癌治疗的发展提供新的方向。