Differential Cooperation of MAPKs with TGF-beta signaling in Epithelial-Mesenchymal Transition

MAPKs 与 TGF-β 信号传导在上皮间质转化中的差异合作

• 批准号: nhmrc : 280913
• 负责人: Dr Hong-Jian Zhu
• 金额: $ 33.16万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/differential-cooperation-mapks-mesenchymal-transition/80908
• 关键词: Differential; Cooperation; MAPKs; TGF; beta

Tumor metastasis - the spread of tumor cells from the original site of growth to other sites in the body, is the biggest threat to survival for patients with solid tumors. The most damage change during cancer progression is the switch from a locally growing tumor to a metastastic killer. For biologist studying cancer, a major challenge is to identify the molecular and cellular mechanisms underlying the switch of non-invasive tumor to an invasive, metastatic state. This application aims to identify key molecular and cellular mechanism controlling this switch, with the ultimate aim being to devise treatments that inhibit tumor metastasis. The results from this work will provide clear and specific targets to prevent and to treat tumor metastasis. More importantly, the success of strategies used in this work can potentially be used clinically for tumor treatment.

肿瘤转移-肿瘤细胞从原始生长部位扩散到体内其他部位，是实体瘤患者生存的最大威胁。癌症进展过程中最大的损害变化是从局部生长的肿瘤转变为肿瘤杀手。对于研究癌症的生物学家来说，一个主要的挑战是确定非侵袭性肿瘤转变为侵袭性转移状态的分子和细胞机制。该应用旨在确定控制这种开关的关键分子和细胞机制，最终目的是设计抑制肿瘤转移的治疗方法。本研究结果将为肿瘤转移的预防和治疗提供明确的靶点。更重要的是，在这项工作中使用的策略的成功可以潜在地用于临床肿瘤治疗。