Expansion of TGF-beta-Smad signaling network and intrinsic epithelial-mesenchymal-endothelial transition

TGF-β-Smad 信号网络的扩展和内在上皮-间质-内皮转化

• 批准号: nhmrc : 433619
• 负责人: Dr Hong-Jian Zhu
• 金额: $ 37.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/expansion-tgf-beta-endothelial-transition/83136
• 关键词: Expansion; TGF; beta; Smad; signaling

The majority of tumor death occurs due to tumor metastasis. Both tumor growth and tumor spread require angiogenesis, which is thought to be driven by tumor but originated from host endothelial cells. Could tumor cells behave and function like endothelial cells? This application aims to detect the transition of adult epithelial cells to endothelial cells through a transient mesenchymal state. Our studies should reveal both the molecular and cellular causes of vasculogenic mimicry, thus establishing a new paradigm in understanding tumor growth and metastasis. Such novel molecular understanding will open up new anti-tumor therapeutic opportunities.

大多数肿瘤死亡是由于肿瘤转移引起的。肿瘤的生长和扩散都需要血管生成，血管生成被认为是由肿瘤驱动的，但起源于宿主内皮细胞。肿瘤细胞的行为和功能是否与内皮细胞相似？本应用旨在检测成人上皮细胞通过瞬时间充质状态向内皮细胞的转变。我们的研究将揭示血管生成模仿的分子和细胞原因，从而为理解肿瘤生长和转移建立一个新的范式。这种新的分子认识将开辟新的抗肿瘤治疗机会。