Smoking Relapse-Prevention Intervention for Cancer Patients

癌症患者的吸烟预防复吸干预措施

• 批准号: 8616353
• 负责人: Vani N Simmons
• 金额: $ 43.89万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8616353
• 关键词: Abstinence; Address; Behavioral; Behavioral Model; Cancer Center; Cancer Patient; Clinical; Cognitive; Coping Skills; Development; Diagnosis; Evaluation; Future; Health; Intervention; Interview; Knowledge; Literature; Malignant Neoplasms; Mediating; Mediator of activation protein; Modality; National Cancer Institute; Nicotine Dependence; Outcome; Pamphlets; Participant; Patients; Personal Satisfaction; Physical Function; Population; Preventive Intervention; Public Health; Quality of life; Randomized; Relapse; Relative (related person); Research; Research Personnel; Risk; Second Primary Cancers; Self Efficacy; Signal Recognition Particle; Smoke; Smoker; Smoking; Smoking Cessation Intervention; Social support; Staging; Testing; Tobacco Dependence; Tobacco use; Treatment Efficacy; base; cancer site; cancer therapy; coping; cost; design; digital; disorder later incidence prevention; efficacy testing; evidence base; follow-up; improved; intervention effect; multi-component intervention; non-smoking; patient population; psychologic; public health relevance; sex; smoking cessation; smoking intervention; smoking relapse; symposium; therapy design; tobacco abstinence; treatment as usual; videodisc

DESCRIPTION (provided by applicant): A growing body of literature illustrates that once a smoker has been diagnosed with cancer, immediate smoking cessation is medically warranted because continued smoking contributes to several adverse health outcomes for cancer patients (e.g., reduction in treatment efficacy, increased risk of developing a second primary cancer, poorer survival). Given the large number of cancer patients making a quit attempt and the high rate of smoking relapse, there is a critical need for evidence-based smoking relapse-prevention interventions for this population. To our knowledge, no smoking relapse-prevention interventions exist for cancer patients. Therefore, the primary aim of this study is to address this gap by testing the efficacy of an empirically based, targeted smoking relapse-prevention intervention for cancer patients. We propose a multimodal intervention comprised of a targeted digital videodisc (DVD) designed specifically for cancer patients and accompanying relapse prevention booklets (Forever Free) that have been previously demonstrated efficacious with the general smoking population. The key content of the targeted DVD is based on Witkiewitz and Marlatt's cognitive-behavioral model of relapse, existing literature, and our prior qualitative and quantitative smoking relapse research conducted with cancer patients. Examples of targeted content include: the effects of continued tobacco use on cancer treatment; benefits of quitting for cancer patients; and interviews with cancer patients who have been successful at maintaining their smoking abstinence. Participants (N = 414) will be randomized to receive usual care (UC) or usual care plus our Smoking Relapse Prevention for Cancer Patients (SRP-CaP) intervention. Based on previous research, we hypothesize that cancer patients who receive the SRP-CaP intervention will demonstrate lower rates of smoking relapse at 6 and 12-month follow-up, relative to patients in the UC condition. Secondary aims of this study are to evaluate the impact of potential mediating and moderating variables on intervention outcomes. The inclusion of possible moderators will allow us to examine whether future relapse-prevention interventions with cancer patients should include additional tailoring. The identification of mediators of intervention effects will guide the development of future smoking interventions as well as aid in the conceptualization of a smoking relapse framework for cancer patients. If demonstrated effective, the proposed intervention would represent an easily disseminable and low-cost intervention with significant public health implications, including improved physical functioning, quality of life, and survival for cancer patients.

描述(由申请人提供)：越来越多的文献表明，一旦吸烟者被诊断出患有癌症，立即戒烟在医学上是有根据的，因为继续吸烟会给癌症患者带来几种不利的健康后果(例如，治疗效果降低，发生第二次原发癌症的风险增加，生存状况更差)。鉴于大量癌症患者尝试戒烟，以及高吸烟率，迫切需要对这一人群进行循证的吸烟复发预防干预。据我们所知，没有针对癌症患者的预防吸烟复发的干预措施。因此，这项研究的主要目的是通过测试针对癌症患者的基于经验的、有针对性的预防吸烟复发干预的有效性来解决这一差距。我们提出了一种多模式干预措施，包括专门为癌症患者设计的有针对性的数字视盘(DVD)和先前已被证明对普通吸烟人群有效的随附预防复发手册(Forever Free)。靶向DVD的主要内容是基于Witkiewitz和Marlatt的复发认知行为模型、现有文献以及我们先前对癌症患者进行的定性和定量吸烟复发研究。有针对性的内容包括：继续使用烟草对癌症治疗的影响；癌症患者戒烟的好处；以及对成功保持戒烟状态的癌症患者的采访。参与者(N=414)将随机接受常规护理(UC)或常规护理加上我们的癌症患者吸烟复发预防(SRP-CAP)干预。基于之前的研究，我们假设接受SRP-CAP干预的癌症患者在6个月和12个月的随访中表现出比UC患者更低的吸烟复发率。本研究的次要目的是评估潜在的中介变量和调节变量对干预结果的影响。纳入可能的主持人将使我们能够检查未来对癌症患者的复发预防干预是否应该包括额外的定制。确定干预效果的中介因素将指导未来吸烟干预措施的发展，并有助于癌症患者吸烟复发框架的概念化。如果证明有效，建议的干预措施将是一种易于传播和低成本的干预措施，具有重大的公共卫生影响，包括改善癌症患者的身体功能、生活质量和生存。