Strengthening behavioral and social science research capacity to address the evolving challenges in HIV care and prevention in Uganda

项目概要： 抗逆转录病毒疗法的有效性和获得抗逆转录病毒疗法的机会增加， 为艾滋病毒感染者（PLHIV）提供更健康、更有成效的生活。然而，这一成功呈现出 艾滋病毒携带者老龄化人口不断增加的意想不到的后果。艾滋病毒感染者面临的老龄化挑战 包括合并症高风险，与老龄化和艾滋病毒有关的交叉耻辱的双重负担， 和加速老化过程。以前的研究表明，老年人感染艾滋病毒的可能性更大， 社会孤立。与艾滋病毒有关的耻辱和年龄歧视的交叉是一个复杂的问题，需要进一步加以解决。 研究实施减少污名化干预措施的设计和可行性。还有一个 迫切需要进行研究，以解决我们对老龄化对健康影响的理解方面的关键差距 以及艾滋病毒感染者加速老化过程的性质。因此，有必要培训 下一代研究人员来解决这些挑战，并设计，实施和扩大规模 为乌干达日益增长的老年艾滋病毒感染者采取量身定制和针对具体情况的干预措施， 资源有限的环境。 在过去的4年里，我们在Makerere建立了一个全面的研究培训计划 大学（Mak），重点是加强行为和社会方面的领导力和专业知识 科学研究（BSSR-D43 TW 011304），以应对艾滋病毒护理和预防方面不断变化的挑战 在乌干达。我们已经建立在麦教师之间的长期和富有成效的合作， 加州旧金山弗朗西斯科（UCSF），为跨学科提供合适的环境 在BSSR训练。我们建议继续该计划，并将重点放在明年和续期申请， 应对艾滋病毒和老龄化的挑战。我们建议提供一年的补助金，以激发研究兴趣 研究艾滋病毒和老龄化问题，并获得初步数据，为该领域未来的长期研究培训提供信息。 具体而言，我们的目标是：1）扩大MakBSSR培训计划，包括艾滋病毒研究培训， 老龄化、年龄歧视和交叉污名，2）为硕士研究生提供研究培训和指导， 博士后研究金学员，以应对乌干达不断变化的艾滋病毒和老龄化挑战，3） 准备MakBSSR研究培训计划的更新申请，重点是艾滋病毒老化， 年龄歧视和交叉污名。该补充文件将利用MakBSSR的现有资源 计划包括社会，行为和生物医学科学家之间的合作，在马克，合作 艾滋病毒项目，以及美国的合作大学。在为期一年的补充期间，我们计划培训一名 硕士研究生和两名博士后研究生，都在麦。

Project summary: The effectiveness of and increased access to antiretroviral therapy (ART) has resulted in longer, healthier, and more productive lives for people living with HIV (PLHIV). However, this success presents unexpected consequences of a growing population of people aging with HIV. Challenges of aging with HIV include a high risk of co-morbidities, a double burden of intersectional stigma related to both aging and HIV, and an accelerated aging process. Previous research has shown that older PLHIV are more likely to be socially isolated. The intersection of HIV-related stigma and ageism is a complex issue requiring further research on the design and feasibility of implementing stigma reduction interventions. There is also an urgent need for research to address critical gaps in our understanding of the impacts of aging on the health of PLHIV and the nature of the accelerated aging process in PLHIV. There is therefore a need to train the next generation of researchers to address these challenges and to design, implement, and scale-up tailored and context-specific interventions for the growing population of older PLHIV in Uganda and similar resource-limited settings. In the past 4 years, we have established a comprehensive research-training program at Makerere University (Mak) with emphasis on strengthening leadership and expertise in Behavioral and Social Sciences Research (BSSR-D43TW011304) to address the evolving challenges in HIV care and prevention in Uganda. We have built on longstanding and productive collaborations between faculty at Mak and the University of California San Francisco (UCSF), to provide a suitable environment for interdisciplinary training in BSSR. We propose to continue the program and focus the next year and a renewal application to address the challenges of HIV and aging. We propose a one-year supplement to spur interest in research on HIV and aging and to obtain preliminary data to inform future long-term research training in this area. Specifically, we aim to: 1) broaden the MakBSSR training program to include research training on HIV and aging, ageism, and intersectional stigma, 2) provide research training and mentorship to masters and postdoctoral fellowship trainees to address the evolving challenges of HIV and aging in Uganda and, 3) prepare a renewal application of the MakBSSR research training program focused on aging with HIV, ageism and intersectional stigma. This supplement will leverage existing resources of the MakBSSR program including collaborations among social, behavioral, and biomedical scientists at Mak, collaborating HIV programs, and partner universities in the USA. During the one-year supplement, we plan to train one master’s degree candidate and two post-doctoral fellowship trainees, all at Mak.