Smoking Relapse-Prevention Intervention for Cancer Patients

癌症患者的吸烟预防复吸干预措施

• 批准号: 8230488
• 负责人: Vani N Simmons
• 金额: $ 45.82万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8230488
• 关键词: Abstinence; Address; Behavioral; Behavioral Model; Cancer Center; Cancer Patient; Clinical; Cognitive; Coping Skills; Development; Diagnosis; Evaluation; Future; Health; Intervention; Interview; Knowledge; Literature; Malignant Neoplasms; Mediating; Mediator of activation protein; Modality; National Cancer Institute; Nicotine Dependence; Outcome; Pamphlets; Participant; Patients; Personal Satisfaction; Physical Function; Population; Preventive Intervention; Public Health; Quality of life; Randomized; Relapse; Relative (related person); Research; Research Personnel; Risk; Second Primary Cancers; Self Efficacy; Signal Recognition Particle; Smoke; Smoker; Smoking; Smoking Cessation Intervention; Social support; Staging; Testing; Tobacco Dependence; Tobacco use; Treatment Efficacy; base; cancer site; cancer therapy; coping; cost; design; digital; disorder later incidence prevention; efficacy testing; evidence base; follow-up; improved; intervention effect; multi-component intervention; non-smoking; patient population; psychologic; public health relevance; sex; smoking cessation; smoking intervention; smoking relapse; symposium; therapy design; tobacco abstinence; treatment as usual; videodisc

DESCRIPTION (provided by applicant): A growing body of literature illustrates that once a smoker has been diagnosed with cancer, immediate smoking cessation is medically warranted because continued smoking contributes to several adverse health outcomes for cancer patients (e.g., reduction in treatment efficacy, increased risk of developing a second primary cancer, poorer survival). Given the large number of cancer patients making a quit attempt and the high rate of smoking relapse, there is a critical need for evidence-based smoking relapse-prevention interventions for this population. To our knowledge, no smoking relapse-prevention interventions exist for cancer patients. Therefore, the primary aim of this study is to address this gap by testing the efficacy of an empirically based, targeted smoking relapse-prevention intervention for cancer patients. We propose a multimodal intervention comprised of a targeted digital videodisc (DVD) designed specifically for cancer patients and accompanying relapse prevention booklets (Forever Free) that have been previously demonstrated efficacious with the general smoking population. The key content of the targeted DVD is based on Witkiewitz and Marlatt's cognitive-behavioral model of relapse, existing literature, and our prior qualitative and quantitative smoking relapse research conducted with cancer patients. Examples of targeted content include: the effects of continued tobacco use on cancer treatment; benefits of quitting for cancer patients; and interviews with cancer patients who have been successful at maintaining their smoking abstinence. Participants (N = 414) will be randomized to receive usual care (UC) or usual care plus our Smoking Relapse Prevention for Cancer Patients (SRP-CaP) intervention. Based on previous research, we hypothesize that cancer patients who receive the SRP-CaP intervention will demonstrate lower rates of smoking relapse at 6 and 12-month follow-up, relative to patients in the UC condition. Secondary aims of this study are to evaluate the impact of potential mediating and moderating variables on intervention outcomes. The inclusion of possible moderators will allow us to examine whether future relapse-prevention interventions with cancer patients should include additional tailoring. The identification of mediators of intervention effects will guide the development of future smoking interventions as well as aid in the conceptualization of a smoking relapse framework for cancer patients. If demonstrated effective, the proposed intervention would represent an easily disseminable and low-cost intervention with significant public health implications, including improved physical functioning, quality of life, and survival for cancer patients. PUBLIC HEALTH RELEVANCE: Continued smoking among cancer patients is related to a number of significant adverse health outcomes. The aim of the proposed study is to test the first smoking relapse- prevention intervention designed specifically for cancer patients. Efforts aimed at maintaining tobacco abstinence among this population could have significant public health implications, including improved physical functioning, quality of life, and survival for cancer patients.

描述（由申请人提供）：越来越多的文献表明，一旦吸烟者被诊断患有癌症，立即戒烟在医学上是有必要的，因为继续吸烟会对癌症患者的健康造成一些不良后果（例如，治疗效果降低、患第二原发性癌症的风险增加、生存时间缩短）。考虑到大量癌症患者尝试戒烟和高吸烟率，这一人群迫切需要循证预防吸烟复发的干预措施。据我们所知，目前还没有针对癌症患者的预防吸烟复吸的干预措施。因此，本研究的主要目的是通过测试一种基于经验的、有针对性的预防癌症患者吸烟复发的干预措施的有效性来解决这一差距。我们提出了一种多模式干预方法，包括专门为癌症患者设计的有针对性的数字视频光盘（DVD）和伴随的预防复发小册子（Forever Free），这些小册子先前已被证明对普通吸烟人群有效。目标DVD的关键内容是基于Witkiewitz和Marlatt的复发认知行为模型，现有文献，以及我们之前对癌症患者进行的定性和定量吸烟复发研究。目标内容的例子包括：继续使用烟草对癌症治疗的影响；癌症患者戒烟的好处并采访了一些成功地保持了戒烟的癌症患者。参与者（N = 414）将随机接受常规治疗（UC）或常规治疗加我们的癌症患者吸烟复发预防（SRP-CaP）干预。基于先前的研究，我们假设接受SRP-CaP干预的癌症患者在6个月和12个月的随访中吸烟复发率较UC患者低。本研究的次要目的是评估潜在的中介和调节变量对干预结果的影响。纳入可能的调节因子将使我们能够检查未来对癌症患者的复发预防干预是否应该包括额外的定制。确定干预效果的中介将指导未来吸烟干预措施的发展，并有助于癌症患者吸烟复发框架的概念化。如果证明有效，提议的干预措施将是一种易于推广和低成本的干预措施，具有重大的公共卫生影响，包括改善癌症患者的身体功能、生活质量和生存率。