Acute Alcohol Use and Suicide

急性酒精使用和自杀

• 批准号: 8515900
• 负责人: Nathalie Huguet
• 金额: $ 27.83万
• 依托单位: PORTLAND STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-20 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8515900
• 关键词: Acute; Address; Age; Alcohol consumption; Alcohol dependence; Alcohols; American; Autopsy; Behavioral Risk Factor Surveillance System; Blood alcohol level measurement; Businesses; Cause of Death; Censuses; Centers for Disease Control and Prevention (U.S.); Cessation of life; Characteristics; Communities; Complex; Consumption; Control Groups; Coroners and Medical Examiners; County; Data; Databases; Development; Environmental Risk Factor; Epidemiology; Ethnic Origin; Event; Firearms; Foundations; Gender; General Population; Goals; Individual; Industry; Ingestion; Intervention; Intoxication; Knowledge; Life; Link; Methods; Motor; National Institute on Alcohol Abuse and Alcoholism; Pattern; Pharmaceutical Preparations; Play; Population; Population Characteristics; Population Control; Preparation; Prevalence; Prevention program; Prevention strategy; Price; Probability; Public Health; Relative (related person); Reporting; Research; Risk Estimate; Risk Factors; Role; Sampling; Self-Injurious Behavior; Subgroup; Suicide; Suicide prevention; Surveys; System; Taxes; Testing; Time; Toxicology; United States; Variant; Violence; alcohol availability; alcohol involvement; alcohol use disorder; comparison group; density of AOD outlets; design; disorder prevention; drinking; male; men; public policy on alcohol; suicidal; suicidal risk; suicide mortality; suicide rate; treatment program; trend; young adult

DESCRIPTION (provided by applicant): This proposal is a revision of R01 AA020063-01 that was reviewed in June 2010 by BGES. The revisions address methodological shortcomings. The project remains significant because suicide is a major national public health problem with about 30,000 deaths each year, representing the 11th leading overall cause of death and the 5th leading cause of years of potential life lost (YPLL) before age 65. Alcohol plays a key role in suicide and, indeed, according to the Centers for Disease Control and Prevention, 6,969 deaths and 235,865 YPLL resulted from alcohol-attributable suicides in 2001. Although alcohol use disorders and suicide have been intensively studied, there is comparatively little research on acute alcohol use and suicide (i.e., drinking prior to the event). Yet, data on acute alcohol use is essential for developing a comprehensive suicide prevention strategy. Research on toxicological characteristics of suicide decedents in the United States has been constrained by small samples and limited geographic coverage. This project will address these limitations using newly available data from the National Violent Death Reporting System (NVDRS), a large (47,398 suicide decedents in 2003-08) and demographically well-characterized database with toxicology information (blood alcohol concentration, BAC) as well as coroner and medical examiner reports pertaining to suicides. The project aims are as follows: (1) describe the epidemiology of blood-alcohol content among suicide decedents in the United States and among major subgroups defined by age, gender, and ethnicity; (2) compare BAC presence and levels at time of suicide to estimated BAC presence and levels in a matched general population control group; (3) examine blood-alcohol content presence and levels in relation to suicide involving different methods (e.g., firearm, hanging, or drug ingestion); and (4) test the effects of alcohol control policies on alcohol-related suicides compared to non-alcohol-related suicides. The project will also examine geographic and temporal variation among those who were and those who were not using alcohol at the time of suicide. The research is built on a multi-level framework in which counties are nested within states. Key environmental predictors will include data on population drinking patterns from the National Epidemiologic Survey on Alcohol and Related Conditions, alcohol availability indicators from the US Census Bureau Business and Industry Data, alcohol tax rates from the Tax Foundation, and firearm access indicators from the Behavioral Risk Factor Surveillance System. Documenting the alcohol-associated suicide mortality levels and trends over time, estimating the risk for the most commonly used method of suicide with alcohol involvement, and evaluating the effects of alcohol control policies on alcohol-positive suicides address fundamental gaps in the understanding of alcohol use in suicide with implications for the harmonization of alcohol policy and suicide prevention strategies.

描述（由申请人提供）：本提案是 R01 AA020063-01 的修订版，BGES 于 2010 年 6 月进行了审查。这些修订解决了方法上的缺陷。该项目仍然具有重要意义，因为自杀是一个重大的国家公共卫生问题，每年约有 30,000 人死亡，是第 11 位主要死亡原因，也是 65 岁之前潜在寿命损失年数 (YPLL) 的第 5 位主要原因。酒精在自杀中起着关键作用，事实上，根据疾病控制和预防中心的数据，2001 年有 6,969 人死亡和 235,865 名 YPLL 是由酒精引起的自杀造成的。酒精 使用障碍和自杀已得到深入研究，但对急性酒精使用和自杀（即事件发生前饮酒）的研究相对较少。然而，急性饮酒数据对于制定全面的自杀预防策略至关重要。美国自杀死者毒理学特征的研究受到样本量小和地理覆盖范围有限的限制。该项目将利用国家暴力死亡报告系统（NVDRS）的最新数据来解决这些限制，该系统是一个大型（2003-08 年有 47,398 名自杀死者）和人口特征良好的数据库，其中包含毒理学信息（血液酒精浓度，BAC）以及与自杀有关的验尸官和法医报告。该项目的目标如下：（1）描述美国自杀者死者以及按年龄、性别和种族定义的主要亚群体中血液酒精含量的流行病学； (2) 将自杀时的 BAC 存在和水平与匹配的一般人群对照组中估计的 BAC 存在和水平进行比较； (3) 检查血液中酒精含量的存在和水平与涉及不同方法（例如枪支、上吊或吸毒）的自杀的关系； (4) 与非酒精相关自杀相比，测试酒精控制政策对酒精相关自杀的影响。该项目还将研究自杀时饮酒和未饮酒的人之间的地理和时间差异。该研究建立在一个多层次的框架上，其中县嵌套在州内。关键的环境预测因素将包括来自全国酒精及相关状况流行病学调查的人口饮酒模式数据、来自美国人口普查局商业和工业数据的酒精供应指标、来自税务基金会的酒精税率以及来自行为风险因素监测系统的枪支准入指标。记录与酒精相关的自杀死亡率水平和随时间变化的趋势，估计与酒精有关的最常用自杀方法的风险，并评估酒精控制政策对酒精阳性自杀的影响，解决对自杀中饮酒的理解上的根本差距，对酒精政策和自杀预防策略的协调具有影响。

项目成果

Heavy Alcohol Use Among Suicide Decedents: Differences in Risk Across Racial-Ethnic Groups.

自杀者的重度饮酒：不同种族群体的风险差异。

• DOI: 10.1176/appi.ps.201500494
• 发表时间: 2016
• 期刊: Psychiatric services (Washington, D.C.)
• 作者: Kaplan,MarkS;Huguet,Nathalie;McFarland,BentsonH;Caetano,Raul;Conner,KennethR;Nolte,KurtB;Giesbrecht,Norman
• 通讯作者: Giesbrecht,Norman

Acute use of alcohol and methods of suicide in a US national sample.

• DOI: 10.2105/ajph.2013.301352
• 发表时间: 2014-01
• 期刊: American journal of public health
• 影响因子: 12.7
• 作者: Conner KR;Huguet N;Caetano R;Giesbrecht N;McFarland BH;Nolte KB;Kaplan MS
• 通讯作者: Kaplan MS

Precipitating Circumstances of Suicide and Alcohol Intoxication Among U.S. Ethnic Groups.

美国各族裔群体中自杀和酒精中毒的诱因。

• DOI: 10.1111/acer.12788
• 发表时间: 2015
• 期刊: Alcoholism, clinical and experimental research
• 作者: Caetano,Raul;Kaplan,MarkS;Huguet,Nathalie;Conner,Kenneth;McFarland,BentsonH;Giesbrecht,Norman;Nolte,KurtB
• 通讯作者: Nolte,KurtB