Alcohol and Adult Development: Etiology, Consequences, and Diagnosis

描述（由申请人提供）：这是NIAAA响应PA-09-076的高级科学家和指导奖的2类申请。该申请旨在延长资助，第二个五年期，为赠款，“酒精和成人发展：病因，后果和诊断”（K 05 AA 017242）。候选人Kenneth J. Sher是密苏里州大学（MU）的心理科学策展人教授，他提议为MU的三位杰出的终身科学家提供一段时间的研究指导。所有这些学员作为独立科学家都有出色的出版记录，但仍然必须通过一个或多个关键的研究里程碑，以充分发挥他们作为研究人员的潜力。John科恩斯是一位临床心理学家和神经科学家，研究大脑功能和认知之间的关系。他以前的大部分工作都是在精神分裂症的认知领域。然而，他越来越多地在酒精和神经认知领域工作，目前获得了NIAAA的R21资助，研究极端饮酒事件对大脑结构和功能的短期至中期影响。科恩斯博士的主要指导目标是增加他对酒精科学和学术的了解，并帮助他过渡到R 01支持，以扩展他目前对极端饮酒影响的研究计划。马特·马滕斯是一位咨询心理学家，主要研究高危饮酒者的简短激励治疗。虽然Martens博士已经从NIAAA获得了两笔R21赠款，但他尚未成功获得R 01支持，使他能够承担更雄心勃勃的项目。像科恩斯博士一样，他的主要目标是在研究问题的框架和有效的资助方面提供指导，这样他就可以更成功地竞争R 01类型的资金。Ian Gizer是一位临床心理学家，接受过遗传学博士后培训。他是一位非常早期的职业科学家，2010年刚刚完成博士后培训。虽然他是三个人中资历最浅的一个，但他是NIDA授予的多个PI资助的PI，这是他还是博士后时写的。然而，为了让他在他的终身职位上取得成功，他需要证明有能力在密苏里州建立一个独立的研究项目，指导研究生和博士后，并获得独立于高级同事合作者的R 01（或同等）支持。对于所有申请人，辅导将涉及提供指导和支持方面的赠款和发展的学员的研究计划，也对更一般的专业发展。将特别注意与学员合作，提高他们作为研究生和博士后学员导师的效率。候选人计划继续追求一个广泛的研究计划，旨在描述酒精中毒的核心病因过程，特别强调在共病精神病理学和人类发展的背景下理解酒精使用障碍（AUDs）的生命历程。此外，候选人提议在第一个预算期开始实施一项新的研究方案，以制定对酒精使用障碍和相关精神病理学进行分类和建模的新方法。

DESCRIPTION (provided by applicant): This is a Type 2 application for a Senior Scientist and Mentoring Award from NIAAA in response to PA-09-076. The application seeks to extend funding, for a second five-year period, for the grant, "Alcohol and Adult Development: Etiology, Consequences, and Diagnosis" (K05AA017242). The Candidate, Kenneth J. Sher, Curators' Professor of Psychological Sciences at the University of Missouri (MU), proposes to provide a period of research mentoring to three outstanding, tenure-track scientists at MU. All of these mentees have excellent publication records as independent scientists but still have to transit one or more key research milestones to reach their full potential as investigators. John Kerns, is a clinical psychologist and neuroscientist who studies the relationship between brain function and cognition. Most of his prior work has been in the area of cognition in schizophrenia. However, he is working increasingly in the area of alcohol and neurocognition and currently has an R21 grant from NIAAA to study the short-to-intermediate effects of extreme drinking episodes on brain structure and function. Primary mentoring goals for Dr. Kerns is to increase his knowledge of alcohol science and scholarship and to help him transition to R01 support to extend his current research program on the effects of extreme drinking. Matt Martens, is a counseling psychologist with primary interests in brief motivational treatments for high-risk drinkers. Although Dr. Martens has had two R21 grants from NIAAA, he has not yet been successful in obtaining R01 support to enable him to take on more ambitious projects. Like Dr. Kerns, a primary goal is to provide mentoring in the areas of framing research questions and effective grantsmanship so that he can be more successful competing for R01-type funding. Ian Gizer is a clinical psychologist with postdoctoral training in genetics. He is a very early career scientist, having just finished his postdoctoral training in 2010. Although the most junior of the three, he is PI on a multiple PI grant from NIDA that was written while he was still a postdoc. However, in order for him to be successful in his tenure track position, he will need to demonstrate the ability to set up an independent research program at Missouri, mentor graduate students and postdocs, and obtain R01 (or equivalent) support independent of senior colleague collaborators. For all applicants, mentoring will involve providing guidance and support with respect to grantsmanship and development of mentees' research programs and also on more general professional development. Particularly attention will be given to working with mentees on their own effectiveness as mentors to graduate students and postdoctoral trainees. The candidate plans to continue to pursue a broad research program that seeks to characterize core etiological processes in alcoholism with particular emphasis on understanding the life course of alcohol use disorders (AUDs) in the context of comorbid psychopathology and human development. In addition, the Candidate proposes to undertake a new research program, begun in the first budget period, to develop new approaches to classifying and modeling alcohol-use disorders and related psychopathology.