Alcohol and Adult Development: Etiology, Consequences, and Diagnosis

描述（由申请人提供）：这是 NIAAA 响应 PA-09-076 的高级科学家和指导奖的 2 类申请。该申请旨在为“酒精与成人发展：病因学、后果和诊断”(K05AA017242) 拨款延长第二个五年期。密苏里大学 (MU) 心理科学策展人教授肯尼思·J·谢尔 (Kenneth J. Sher) 候选人提议为密苏里大学三位杰出的终身教授科学家提供一段时间的研究指导。所有这些受训者作为独立科学家都拥有出色的发表记录，但仍需要通过一个或多个关键研究里程碑才能充分发挥研究人员的潜力。约翰·克恩斯 (John Kerns) 是一位临床心理学家和神经科学家，研究大脑功能与认知之间的关系。他之前的大部分工作都是在精神分裂症的认知领域。然而，他越来越多地致力于酒精和神经认知领域的研究，目前获得 NIAAA 的 R21 资助，用于研究极端饮酒事件对大脑结构和功能的短期到中期影响。 Kerns 博士的主要指导目标是增加他对酒精科学和学术的了解，并帮助他过渡到 R01 支持，以扩展他目前关于极度饮酒影响的研究项目。马特·马滕斯 (Matt Martens) 是一位咨询心理学家，主要研究针对高风险饮酒者的简短激励治疗。尽管 Dr. Martens 已获得 NIAAA 的两次 R21 资助，但他尚未成功获得 R01 支持，使他能够承担更雄心勃勃的项目。与 Kerns 博士一样，他的主要目标是在制定研究问题和有效资助方面提供指导，以便他能够更成功地竞争 R01 型资助。 Ian Gizer 是一位临床心理学家，接受过遗传学博士后培训。他是一位非常早期的职业科学家，刚刚在 2010 年完成博士后培训。虽然他是三人中资历最低的，但他是 NIDA 多项 PI 资助的 PI，该资助是在他还是博士后时撰写的。然而，为了让他在终身教职中取得成功，他需要证明有能力在密苏里州建立独立研究项目、指导研究生和博士后，并获得独立于高级同事合作者的 R01（或同等）支持。对于所有申请人来说，指导将包括在资助和受训者研究项目的发展以及更一般的专业发展方面提供指导和支持。我们将特别关注与学员合作，提高他们作为研究生和博士后实习生导师的有效性。该候选人计划继续开展广泛的研究计划，旨在描述酗酒的核心病因过程，特别强调在共病精神病理学和人类发展的背景下了解酒精使用障碍（AUD）的生命历程。此外，候选人提议在第一个预算期开始开展一项新的研究计划，以开发对酒精使用障碍和相关精神病理学进行分类和建模的新方法。

DESCRIPTION (provided by applicant): This is a Type 2 application for a Senior Scientist and Mentoring Award from NIAAA in response to PA-09-076. The application seeks to extend funding, for a second five-year period, for the grant, "Alcohol and Adult Development: Etiology, Consequences, and Diagnosis" (K05AA017242). The Candidate, Kenneth J. Sher, Curators' Professor of Psychological Sciences at the University of Missouri (MU), proposes to provide a period of research mentoring to three outstanding, tenure-track scientists at MU. All of these mentees have excellent publication records as independent scientists but still have to transit one or more key research milestones to reach their full potential as investigators. John Kerns, is a clinical psychologist and neuroscientist who studies the relationship between brain function and cognition. Most of his prior work has been in the area of cognition in schizophrenia. However, he is working increasingly in the area of alcohol and neurocognition and currently has an R21 grant from NIAAA to study the short-to-intermediate effects of extreme drinking episodes on brain structure and function. Primary mentoring goals for Dr. Kerns is to increase his knowledge of alcohol science and scholarship and to help him transition to R01 support to extend his current research program on the effects of extreme drinking. Matt Martens, is a counseling psychologist with primary interests in brief motivational treatments for high-risk drinkers. Although Dr. Martens has had two R21 grants from NIAAA, he has not yet been successful in obtaining R01 support to enable him to take on more ambitious projects. Like Dr. Kerns, a primary goal is to provide mentoring in the areas of framing research questions and effective grantsmanship so that he can be more successful competing for R01-type funding. Ian Gizer is a clinical psychologist with postdoctoral training in genetics. He is a very early career scientist, having just finished his postdoctoral training in 2010. Although the most junior of the three, he is PI on a multiple PI grant from NIDA that was written while he was still a postdoc. However, in order for him to be successful in his tenure track position, he will need to demonstrate the ability to set up an independent research program at Missouri, mentor graduate students and postdocs, and obtain R01 (or equivalent) support independent of senior colleague collaborators. For all applicants, mentoring will involve providing guidance and support with respect to grantsmanship and development of mentees' research programs and also on more general professional development. Particularly attention will be given to working with mentees on their own effectiveness as mentors to graduate students and postdoctoral trainees. The candidate plans to continue to pursue a broad research program that seeks to characterize core etiological processes in alcoholism with particular emphasis on understanding the life course of alcohol use disorders (AUDs) in the context of comorbid psychopathology and human development. In addition, the Candidate proposes to undertake a new research program, begun in the first budget period, to develop new approaches to classifying and modeling alcohol-use disorders and related psychopathology.