Alcohol and Adult Development: Etiology, Consequences, and Diagnosis

描述(申请人提供)：这是根据PA-09-076向NIAAA申请高级科学家和导师奖的第二类申请。该申请旨在为赠款“酗酒与成人发育：病因、后果和诊断”(K05AA017242)提供第二个五年期的资金。这位候选人是密苏里大学(MU)心理科学策展人教授肯尼斯·J·谢尔(Kenneth J.Sher)，他提议为密苏里大学三位杰出的终身教职科学家提供一段时间的研究指导。所有这些被辅导者作为独立科学家都有很好的发表记录，但仍然必须跨越一个或多个关键研究里程碑，才能充分发挥他们作为研究人员的潜力。约翰·科恩斯是一位临床心理学家和神经学家，研究大脑功能和认知之间的关系。他之前的大部分工作都是在精神分裂症的认知领域。然而，他越来越多地在酒精和神经认知领域工作，目前获得了NIAAA的R21拨款，用于研究极端饮酒对大脑结构和功能的短期到中期影响。克恩斯博士的主要指导目标是增加他对酒精科学和学术的了解，并帮助他过渡到R01支持，以延长他目前关于极端饮酒影响的研究项目。马特·马滕斯是一位咨询心理学家，他的主要兴趣是为高风险饮酒者提供简短的激励疗法。尽管马滕斯博士已经从NIAAA获得了两笔R21拨款，但他还没有成功地获得R01的支持，使他能够承担更雄心勃勃的项目。像克恩斯博士一样，他的主要目标是在构建研究问题和有效的资助技巧方面提供指导，这样他就可以更成功地竞争R01类型的资金。伊恩·吉泽是一名临床心理学家，曾在遗传学方面接受博士后培训。他是一名非常早期的职业科学家，2010年刚刚完成博士后培训。虽然他是三人中最初级的，但他是NIDA授予的多次PI补助金的PI，这是他还是一名博士后时写的。然而，为了让他在终身教职跟踪职位上取得成功，他需要证明有能力在密苏里州建立一个独立的研究项目，指导研究生和博士后，并获得独立于资深同事合作者的R01(或同等)支持。对于所有申请者，辅导将包括提供有关资助金和学员研究计划的发展以及更一般的专业发展方面的指导和支持。作为研究生和博士后实习生的导师，将特别注意与被辅导者合作，以提高他们自身的有效性。候选人计划继续进行一项广泛的研究计划，寻求表征酒精中毒的核心病因学过程，特别强调在精神病理学和人类发育并存的背景下理解酒精使用障碍(AUD)的生活过程。此外，候选人建议开展一项新的研究计划，从第一个预算期开始，开发新的方法来对酒精使用障碍和相关的精神病理学进行分类和建模。

DESCRIPTION (provided by applicant): This is a Type 2 application for a Senior Scientist and Mentoring Award from NIAAA in response to PA-09-076. The application seeks to extend funding, for a second five-year period, for the grant, "Alcohol and Adult Development: Etiology, Consequences, and Diagnosis" (K05AA017242). The Candidate, Kenneth J. Sher, Curators' Professor of Psychological Sciences at the University of Missouri (MU), proposes to provide a period of research mentoring to three outstanding, tenure-track scientists at MU. All of these mentees have excellent publication records as independent scientists but still have to transit one or more key research milestones to reach their full potential as investigators. John Kerns, is a clinical psychologist and neuroscientist who studies the relationship between brain function and cognition. Most of his prior work has been in the area of cognition in schizophrenia. However, he is working increasingly in the area of alcohol and neurocognition and currently has an R21 grant from NIAAA to study the short-to-intermediate effects of extreme drinking episodes on brain structure and function. Primary mentoring goals for Dr. Kerns is to increase his knowledge of alcohol science and scholarship and to help him transition to R01 support to extend his current research program on the effects of extreme drinking. Matt Martens, is a counseling psychologist with primary interests in brief motivational treatments for high-risk drinkers. Although Dr. Martens has had two R21 grants from NIAAA, he has not yet been successful in obtaining R01 support to enable him to take on more ambitious projects. Like Dr. Kerns, a primary goal is to provide mentoring in the areas of framing research questions and effective grantsmanship so that he can be more successful competing for R01-type funding. Ian Gizer is a clinical psychologist with postdoctoral training in genetics. He is a very early career scientist, having just finished his postdoctoral training in 2010. Although the most junior of the three, he is PI on a multiple PI grant from NIDA that was written while he was still a postdoc. However, in order for him to be successful in his tenure track position, he will need to demonstrate the ability to set up an independent research program at Missouri, mentor graduate students and postdocs, and obtain R01 (or equivalent) support independent of senior colleague collaborators. For all applicants, mentoring will involve providing guidance and support with respect to grantsmanship and development of mentees' research programs and also on more general professional development. Particularly attention will be given to working with mentees on their own effectiveness as mentors to graduate students and postdoctoral trainees. The candidate plans to continue to pursue a broad research program that seeks to characterize core etiological processes in alcoholism with particular emphasis on understanding the life course of alcohol use disorders (AUDs) in the context of comorbid psychopathology and human development. In addition, the Candidate proposes to undertake a new research program, begun in the first budget period, to develop new approaches to classifying and modeling alcohol-use disorders and related psychopathology.