Integrative systems pharmacology, neutron reflectometry and molecular dynamics approaches to unravelling the interactions between polymyxins and bacterial membranes

综合系统药理学、中子反射测定法和分子动力学方法来揭示多粘菌素和细菌膜之间的相互作用

• 批准号: nhmrc : GNT1144652
• 负责人: A/Pr Tony Velkov
• 金额: $ 96.8万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/integrative-systems-pharmacology-bacterial-membranes/1348626
• 关键词: Integrative; systems; pharmacology; neutron; reflectometry

Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii are among the 6 top-priority dangerous ‘superbugs’ causing life-threatening infections worldwide. This study will employ a multi-disciplinary approach to decipher the complex interactions of polymyxins with the membranes of these three ‘superbugs’ and to discover novel antibiotics with superior efficacy. This innovative project targets the urgent unmet global medical crisis due to antibiotic resistance.

肺炎克雷伯氏菌、铜绿假单胞菌和鲍曼不动杆菌是世界范围内导致危及生命感染的6种最危险的“超级细菌”之一。这项研究将采用多学科的方法来破译多粘菌素与这三种“超级细菌”的膜的复杂相互作用，并发现具有上级疗效的新型抗生素。这一创新项目旨在解决由于抗生素耐药性而导致的紧迫的全球医疗危机。