Sourcerer IC: A Web-Based Integrative Multi-Modal Workflow for Epilepsy Surgical Planning

Sourcerer IC：基于网络的癫痫手术计划综合多模式工作流程

• 批准号: 10379723
• 负责人: PHAN LUU
• 金额: $ 26.24万
• 依托单位: BRAIN ELECTROPHYSIOLOGY LABORATORY COMPANY, LLC
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10379723
• 关键词: Accounting; Achievement; Anatomy; Brain; Brain region; Clinical; Cognitive; Complex; Computer software; Data; Databases; Development; Digital Imaging and Communications in Medicine; Electrodes; Electroencephalography; Ensure; Environment; Epilepsy; Evaluation; Excision; Failure; Foundations; Functional Magnetic Resonance Imaging; Goals; Guidelines; Head; Hospitals; Image; Image Analysis; Implant; Individual; Intuition; Life; Magnetic Resonance Imaging; Measures; Methods; Modality; Modeling; Monitor; Movement; Multimodal Imaging; Neuronavigation; Neuropsychology; Neurosurgeon; Online Systems; Operative Surgical Procedures; Patients; Persons; Pharmaceutical Preparations; Pharmacology; Phase; Physicians; Positioning Attribute; Positron-Emission Tomography; Postoperative Period; Preparation; Procedures; Public Health; Regulation; Research; Resistance; Resolution; Secure; Seizures; Site; Small Business Innovation Research Grant; Source; Structure; Symptoms; System; Technology; Testing; Tissues; Transact; Validation; Work; X-Ray Computed Tomography; bioimaging; brain abnormalities; brain tissue; candidate identification; cost; cost estimate; cranium; data resource; design; electrical source imaging; experience; image guided; imaging modality; implantation; improved; innovation; life time cost; multimodal neuroimaging; multimodality; neurosurgery; product development; single photon emission computed tomography; source localization; success; tool; treatment response; usability; web interface

Abstract The overarching goal of this project is to create software that improves the use of intracranial EEG to qualify patients with medication-resistant epilepsy for neurosurgery. One million people in the US suffer from continual seizures that are not controlled by medication. The current estimate is that half of these could be treated effectively by surgical resection of the epileptic cortical tissue, and yet the majority of them will not receive the surgery (Engel & Wiebe, 2012). There are 200 Comprehensive Epilepsy Centers in the US that are certified to provide both the epilepsy resection and the multimodal presurgical evaluation (clinical semiology, neuropsychological assessment, EEG, MRI, PET, and intracranial or icEEG). A problem for this evaluation is the software for integrating the multiple imaging and assessment modalities in the presurgical workup to allow confidence in the neurosurgical plan. The localization of the icEEG electrodes is often problematic because of brain shift (movement and deformation of the brain from the preoperative imaging to the postoperative CT used for electrode position imaging). With recent advances in dense array EEG (dEEG) with individual head conductivity models, electrical source imaging can provide noninvasive estimates of the seizure onset zone, which could then guide more focused and effective icEEG probes, and potentially more confident and limited neurosurgical resections. The present SBIR research builds on our extensive experience with icEEG electrode localization, multimodal neuroimage registration, dEEG source imaging, and user interface design to create Sourcerer IC, a software platform optimized for bringing multiple forms of evidence to interpret icEEG measures and improve the localization of the seizure onset zone. The key innovations of this project are: the integration of multimodal neuroimaging data (MRI, dwMRI, fMRI, PET) registered precisely with structural MRI in a DICOM format for export to the neurosurgeon’s neuronavigator software; the capacity for noninvasive dEEG source localization of spikes and seizure onset with individual head conductivity models in preparation for icEEG electrode placement (as validation rather than exploration); the correction of brain shift due to surgical implanting of icEEG electrodes by registering the postoperative CT to the preoperative MRI; and perhaps most importantly, the integration of all components of the presurgical workup within an intuitive and usable software workflow with full quality system regulation and validation following FDA guidelines. Sourcerer IC will build on the many years of experience with Yale’s BioImage Suite, such that physicians and technicians access their components of the workflow through secure web interfaces, and the networked database maintains and integrates all transactions to coordinate computational as well as data resources for efficient completion, review, and implementation of an optimized neurosurgical plan.

抽象的 该项目的总体目标是创建改善颅内使用的软件 脑电图使耐药性癫痫患者有资格进行神经外科手术。 100万人 在美国，不受药物控制的持续癫痫发作。电流 估计是，其中一半可以通过手术切除的癫痫病有效治疗 皮质组织，但大多数人都不会接受手术（Engel＆Wiebe，2012年）。 美国有200个综合癫痫中心已获得认证以提供 癫痫切除和多模式的前评估（临床半学，， 神经心理学评估，脑电图，MRI，PET和颅内或ICEEG）。这个问题 评估是将多种成像和评估方式整合到中的软件 术前检查以使神经外科计划有信心。冰原的本地化 由于大脑的移动和变形，电极通常是有问题的 从术前成像到用于电极位置成像的术后CT）。 随着密集阵列EEG（DEEG）的最新进展，具有单个头部电导率模型， 电源成像可以提供癫痫发作区的无创估计值，该区域 然后可以指导更加专注和有效的ICEEG问题，并可能更自信，并且 有限的神经外科切除术。目前的SBIR研究以我们的丰富经验为基础 随着ICEEG电极定位，多模式神经图像登记，DEEG源成像， 和用户界面设计以创建souderer ic，这是一个优化用于带来的软件平台 多种形式的证据来解释ICEEG测量并改善 癫痫发作区。该项目的关键创新是：多模式的集成 神经影像数据（MRI，DWMRI，FMRI，PET）在A中精确注册了结构MRI DICOM格式用于导出到神经外科神经元护酮软件；能力 无创的DEEG来源的尖峰和癫痫发作的定位 电导率模型，以准备放置Iceeg电极（作为验证而不是 勘探）;通过手术植入ICEEG电极引起的大脑转移的校正 将术后CT注册到术前MRI中；最重要的是， 在直观且可用的软件中将所有组件的所有组件集成 遵循FDA指南的全质量系统调节和验证的工作流程。我们人 IC将基于耶鲁的生物图像套件的多年经验，以便医生 技术人员通过安全的Web界面访问工作流程的组件， 网络数据库维护并集成了所有交易以协调计算 以及有效完成，审查和实施优化的数据资源 神经外科计划。