Investigating the role of bvFTD-affected networks in socioemotional behavior

调查受 bvFTD 影响的网络在社会情感行为中的作用

基本信息

项目摘要

ABSTRACT The behavioral variant of frontotemporal dementia (bvFTD) is one of only a handful of neurologic syndromes for whom initial clinical diagnosis relies entirely on assessment of patients' social and emotional symptoms. Until recently, no measures of socioemotional behavior were psychometrically validated in neurodegenerative disease patients. In its first four years, this project has directly addressed this problem by successfully developing such measures, a subset of which have already been incorporated into an FTD testing module promoted by National Institute of Aging through the National Alzheimer's Disease Coordinating Centers. Now that these tests have been developed, we hope to use them to model the neural systems underlying human socioemotional behavior in both healthy and disease states. This proposal builds on the recent discovery that each major neurodegenerative disorders initially targets a distinctive intrinsically connected functional network (ICN) in the brain. Three of these ICNs have been identified as the initial site of dysfunction in different clinical subtypes of bvFTD: the ventral salience network (SN), the task control network (TCN), and the semantic- context network (SCN). Still, little is known about the specific socioemotional behaviors driven by these ICNs, either in normal cognition or in disease. By identifying how these tests reflect network connectivity, we can use them to more easily screen patients for early bvFTD, measure symptom progression, and better predict patients' underlying neuropathology. The Specific Aims of this project are to elucidate the contribution of these three neural networks to normal social behavior and to the socioemotional symptoms of bvFTD: AIM 1: To clarify how the three bvFTD networks correspond to socioemotional behavior and cognition in healthy normal adults. We will collect resting-state MRI (rsMRI) and social testing data from 40 younger controls (ages 20-45), which together with data collected from healthy older controls (ages 45-90) during the first phase of this project. We hypothesize that scores on measures of visceral emotional reactivity will correlate with SN connectivity; social self-control will correlate with TCN connectivity; and tasks requiring applied socioemotional knowledge will correlate with SCN connectivity. AIM 2: To determine how these three networks relate to severity of social dysfunction in bvFTD. We will collect rsMRI and social data from 50 bvFTD patients, which when added to data collected during the first phase of this project, will provide adequate power to investigate the correspondence between patients' socioemotional symptoms and network dysfunction. AIM 3: To examine socioemotional and network dysfunction occurring at the earliest stage of bvFTD. For this more exploratory aim, we will collect rsMRI and social data yearly from a cohort of 30 presymptomatic carriers (PC) and 30 non-carriers (NONC) from families with FTD-causing gene mutations, to examine patterns of progressive change in socioemotional function in PCs who later develop a behavioral phenotype, and identify socioemotional changes in PCs that correspond to altered connectivity in the three ICNs.
摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Katherine P Rankin其他文献

Predicting amyloid status in corticobasal syndrome using modified clinical criteria, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography
  • DOI:
    10.1186/s13195-014-0093-y
  • 发表时间:
    2015-03-02
  • 期刊:
  • 影响因子:
    7.600
  • 作者:
    Sharon J Sha;Pia M Ghosh;Suzee E Lee;Chiara Corbetta-Rastelli;Willian J Jagust;John Kornak;Katherine P Rankin;Lea T Grinberg;Harry V Vinters;Mario F Mendez;Dennis W Dickson;William W Seeley;Marilu Gorno-Tempini;Joel Kramer;Bruce L Miller;Adam L Boxer;Gil D Rabinovici
  • 通讯作者:
    Gil D Rabinovici

Katherine P Rankin的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Katherine P Rankin', 18)}}的其他基金

Core C: Data Management and Statistics Core
核心C:数据管理和统计核心
  • 批准号:
    10647906
  • 财政年份:
    2019
  • 资助金额:
    $ 51.73万
  • 项目类别:
Core C: Data Management and Statistics Core
核心C:数据管理和统计核心
  • 批准号:
    10431781
  • 财政年份:
    2019
  • 资助金额:
    $ 51.73万
  • 项目类别:
Identifying the clinicopathologic basis of dementia-related psychosis
确定痴呆相关精神病的临床病理基础
  • 批准号:
    8573258
  • 财政年份:
    2013
  • 资助金额:
    $ 51.73万
  • 项目类别:
Measuring Altered Social Behavior in Neurodegenerative Disease
测量神经退行性疾病中社会行为的改变
  • 批准号:
    8236958
  • 财政年份:
    2008
  • 资助金额:
    $ 51.73万
  • 项目类别:
Measuring Altered Social Behavior in Neurodegenerative Disease
测量神经退行性疾病中社会行为的改变
  • 批准号:
    7795783
  • 财政年份:
    2008
  • 资助金额:
    $ 51.73万
  • 项目类别:
Measuring Altered Social Behavior in Neurodegenerative Disease
测量神经退行性疾病中社会行为的改变
  • 批准号:
    7610986
  • 财政年份:
    2008
  • 资助金额:
    $ 51.73万
  • 项目类别:
Measuring Altered Social Behavior in Neurodegenerative Disease
测量神经退行性疾病中社会行为的改变
  • 批准号:
    8053787
  • 财政年份:
    2008
  • 资助金额:
    $ 51.73万
  • 项目类别:
Measuring Altered Social Behavior in Neurodegenerative Disease
测量神经退行性疾病中社会行为的改变
  • 批准号:
    7465327
  • 财政年份:
    2008
  • 资助金额:
    $ 51.73万
  • 项目类别:
Investigating the role of bvFTD-affected networks in socioemotional behavior
调查受 bvFTD 影响的网络在社会情感行为中的作用
  • 批准号:
    9040068
  • 财政年份:
    2008
  • 资助金额:
    $ 51.73万
  • 项目类别:
Measuring Altered Social Behavior in Neurodegenerative Disease
测量神经退行性疾病中社会行为的改变
  • 批准号:
    8699320
  • 财政年份:
    2008
  • 资助金额:
    $ 51.73万
  • 项目类别:

相似海外基金

Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
  • 批准号:
    MR/Z503605/1
  • 财政年份:
    2024
  • 资助金额:
    $ 51.73万
  • 项目类别:
    Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
  • 批准号:
    2336167
  • 财政年份:
    2024
  • 资助金额:
    $ 51.73万
  • 项目类别:
    Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
  • 批准号:
    2402691
  • 财政年份:
    2024
  • 资助金额:
    $ 51.73万
  • 项目类别:
    Standard Grant
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
  • 批准号:
    2341428
  • 财政年份:
    2024
  • 资助金额:
    $ 51.73万
  • 项目类别:
    Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
  • 批准号:
    24K12150
  • 财政年份:
    2024
  • 资助金额:
    $ 51.73万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
  • 批准号:
    DE240100561
  • 财政年份:
    2024
  • 资助金额:
    $ 51.73万
  • 项目类别:
    Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
  • 批准号:
    10065645
  • 财政年份:
    2023
  • 资助金额:
    $ 51.73万
  • 项目类别:
    Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
  • 批准号:
    23K09542
  • 财政年份:
    2023
  • 资助金额:
    $ 51.73万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
  • 批准号:
    23K07552
  • 财政年份:
    2023
  • 资助金额:
    $ 51.73万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
  • 批准号:
    23K07559
  • 财政年份:
    2023
  • 资助金额:
    $ 51.73万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了