Integrin-growth factor interactions in the development of airway wall remodelling

气道壁重塑发展中整合素-生长因子的相互作用

• 批准号: nhmrc : 254510
• 负责人: Prof Darryl Knight
• 金额: $ 27.03万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/integrin-growth-factor-wall-remodelling/77395
• 关键词: Integrin; growth; factor; interactions; development

Asthma is a clinically and socio-economically important disease with prevalence in the Australian population of approximately 13% for adults and approaching 25% for children. Currently, glucocorticoids (GCS) are first line prophylactic therapy for the disease. Despite a wide diversity of precipitating factors, the mechanisms underlying its pathogenesis remain unclear. A marked thickening of the airway wall bought about by excessive deposition of extracellular matrix is a prominent pathological feature but why this occurs and how it can be prevented is equally unclear. Recent studies have suggested that interactions between cells and the extracellular matrix influence the airways response to inflammation and modulate the effectiveness of currently available therapies. Indeed, there is mounting evidence to suggest that GCS fail to modulate and indeed in some cases even contribute to structural changes in the remodeled airway wall. The aim of this study is to assess the mechanisms by which cells and the extracellular matrix interact to promote remodelling of the airway wall and to determine whether this association influences the responsiveness to traditional asthma therapies.

哮喘是一种临床上和社会经济上重要的疾病，在澳大利亚人口中，成人患病率约为13%，儿童患病率接近25%。目前，糖皮质激素（GCS）是该疾病的一线预防治疗。尽管诱发因素多种多样，但其发病机制尚不清楚。由细胞外基质过度沉积引起的气道壁明显增厚是一个突出的病理特征，但这种情况发生的原因和如何预防也同样不清楚。最近的研究表明，细胞与细胞外基质之间的相互作用影响气道对炎症的反应，并调节当前可用治疗的有效性。事实上，越来越多的证据表明，GCS不能调节，在某些情况下甚至会导致气道壁重构的结构变化。本研究的目的是评估细胞和细胞外基质相互作用促进气道壁重塑的机制，并确定这种关联是否影响对传统哮喘治疗的反应性。