Modifying epigenetics as a novel treatment in COPD

修改表观遗传学作为慢性阻塞性肺病的新型治疗方法

• 批准号: nhmrc : 1079184
• 负责人: Prof Darryl Knight
• 金额: $ 74.87万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modifying-epigenetics-novel-treatment-copd/518641
• 关键词: Modifying; epigenetics; novel; treatment; COPD

Smoking leads to inflammation that causes emphysema, which is a major health problem. Once induced there is a progressive decline in health, which continues even after stopping smoking. There are no treatments that halt this decline. Recently smoking-induced changes in genes have been discovered that control inflammation. We may be able to reverse these changes and stop the induction and progression of emphysema. This project may lead to a completely new way of preventing and treating emphysema.

吸烟会导致炎症，从而导致肺气肿，这是一个主要的健康问题。一旦诱发，健康状况就会逐渐恶化，甚至在戒烟后也会继续恶化。没有任何治疗方法可以阻止这种下降。最近发现吸烟引起的基因变化可以控制炎症。我们也许能够逆转这些变化并阻止肺气肿的诱发和进展。该项目可能会带来一种预防和治疗肺气肿的全新方法。