2013 Infections of the Nervous System: Pathogenesis and Worldwide Impact GRC

描述(申请人提供)：我们建议举办一次新的戈登研究会议(GRC)，主题是“神经系统感染：发病机制和世界影响”，因为嗜神经性病原体对世界各地的人类痛苦和疾病负担有重大贡献，特别是在热带和发展中国家。与西方社会对神经系统感染的研究相比，发展中国家对这类疾病的研究被忽视了。这是自相矛盾的，因为嗜神经性病原体在发展中国家很常见，对人类的痛苦和疾病负担有很大贡献。此外，患有神经性残疾和/或认知功能障碍将对社会经济发展产生重大影响。这次会议的范围将是前所未有的广泛，聚集了由这些病原体引起的重大疾病的顶尖科学家。我们的目标是增进该领域的知识，促进资源丰富和贫困地区的医学研究中心之间的交流。这一新的GRC系列将汇集著名的临床医生和科学家，他们研究人类神经系统全球感染的临床疾病表现和潜在的分子机制。建立一个致力于神经系统感染的顶级科学家的强大社区，也将提高世界领先的研究机构对这一领域的影响和挑战的认识，并促进该主题的新研究和培训计划。会议将以主旨讲座开始，随后将举行科学会议，详细讨论不同病原体入侵神经系统的方式如何不同；嗜神经病原体的特定神经靶细胞及其受体是什么；对入侵病原体的免疫和神经反应的特征是什么；临床和发病机制研究如何能够阐明由不同病原体造成的神经系统损害的性质；在所涵盖的一些疾病中，治疗和诊断的新前景是什么。GRC的形式(以社区为基础，受众较少，专注于未发表的材料)是创建包括临床医生和科学家在内的多学科对话的理想选择。在这方面，会议的另一个重要目标将是不吸引来自各大洲的年轻研究人员/实习生，特别是在这些疾病流行的地方，他们将提供海报和/或简短的口头陈述，使他们有充分的时间与专家讨论他们的工作。因此，至关重要的是，本次会议能够依靠和支持该领域最优秀的科学家的出席。我们相信，这次会议将通过扩大对这些破坏性神经疾病的临床方面和发病机制的了解，并促进在预防、诊断和治疗方面的进展，推动NINDS的使命。Bruzzone GRC 2013神经系统感染。

DESCRIPTION (provided by applicant): We propose to hold a new Gordon Research Conference (GRC) on "Infections of the nervous system: pathogenesis and world impact" because neurotropic pathogens contribute significantly to human suffering and disease burden throughout the world, particularly in tropical and developing countries. In comparison to studies on infections of the nervous system in western societies, studies on diseases of such nature in the developing world have been neglected. This is paradoxical as neurotropic pathogens are frequent in the developing world and contribute significantly to human suffering and disease burden. Moreover living with neurological handicap and/or cognitive dysfunction will have a significant impact on socio-economic development. The conference will have an unprecedented broad scope, gathering leading scientists on major diseases caused by these pathogens. Our goals are to advance knowledge in the field and promote exchanges between medical research centers in resource-rich and -poor regions. This new series of GRC will bring together renowned clinicians and scientists, who investigate clinical disease manifestations and the molecular mechanisms underlying worldwide infections of the nervous system in humans. The establishment of a strong community of top-ranked scientists working on infections of the nervous system will also increase the awareness of world-leading research institutions on the impact and challenges in this field and foster new research and training programs in that topic. The conference will open with keynote lectures followed by scientific sessions that will address in detail how ways of invading the nervous system vary between pathogens; what are the specific neural target cells and their receptors for neurotropic pathogens; what are the characteristics of the immune and neural responses to invading pathogens; how clinical and pathogenesis studies can elucidate the nature of the nervous system damage caused by different pathogens; what are the new prospects for therapies and diagnostic in some of the diseases covered. The format of GRC (community- based, small audience, focus on unpublished material) is ideal to create a multidisciplinary dialogue that will involve both clinicians and scientists. In this context, another important objective of the conference will be t attract from all continents an audience of young researchers/trainees in the field, particularly those where these diseases are prevalent, who will present posters and/or short oral presentations, giving them ample time to discuss their work with the experts. It is, therefore, crucial that this conference can count on and support the presence of the best scientists in the field. We believe that this conference will advance the mission of NINDS by expanding the knowledge on clinical aspects and pathogenesis of these devastating neurological diseases and promoting progress in their prevention, diagnostic and therapies. Bruzzone GRC 2013 Infections of the nervous system .