CLINICAL AND IMAGING CORE SUPPORT OF ACUTE STROKE RESEARCH

急性卒中转化研究项目的基础是急性卒中临床服务，它将确保最大限度的患者转诊，并允许快速识别、筛选和招募潜在的研究对象，及时研究脑缺血的早期事件，并将患者纳入急性卒中研究方案。由于缺乏急诊科，以及筛查和招募急性中风患者作为研究对象的时间限制，NIH临床中心无法作为我们研究项目的主要地点。因此，我们需要在当地医院、马里兰州贝塞斯达的郊区医院（SH）和华盛顿特区的华盛顿医院中心（WHC）建立和维护支持这一项目所需的临床、成像和研究基础设施。该基础设施的主要组成部分包括NIH中风服务，NIH和承包商临床医生中风神经科医生、护士、临床研究员、现场研究/护士协调员的组合，NIH 3T MRI MRI在WHC，在SH和MRI技术人员共享1.5 T扫描仪，NIH计算机网络放置和维护在每个医院，医院办公空间的项目需求。此外，我们为WHC和SH MRI扫描仪获得的图像维护自己的PACS，并开发和维护临床和研究患者数据的注册表。每年我们筛选大约1200名患者，并招募大约100名患者进入我们的临床研究方案之一。

The foundation of an acute stroke translational research program is an acute stroke clinical service that will assure maximum patient referral and allow rapid identification, screening and recruitment of potential research subjects in the timely fashion needed to study the early events in cerebral ischemia and enroll patients in acute stroke research protocols. Absence of an emergency department and the time constraints on screening and recruitment of acute stroke patients as research subjects has precluded the NIH Clinical Center as the main site of our research projects. Thus, we have needed to establish and maintain the clinical, imaging and research infrastructure required to support such a program at local hospitals, Suburban Hospital (SH) in Bethesda, Maryland, and Washington Hospital Center (WHC) in DC. The major elements of this infrastructure include the NIH Stroke Service, a combination of NIH and contractor clinicians stroke neurologists, nurses, clinical fellows, on-site research/nurse coordinators, MRI scanners NIH 3T MRI at WHC, shared 1.5 T scanner at SH and MRI technologists, NIH computer network placed and maintained at each hospital, hospital office space for program needs. In addition, we maintain our own PACS for images obtained on the WHC and SH MRI scanners, and developed and maintain a registry for clinical and research patient data. Every year we screen approximately 1200 patients and enroll approximately 100 patients into one of our clinical research protocols.