CLINICAL AND IMAGING CORE SUPPORT OF ACUTE STROKE RESEARCH

急性卒中研究计划的基础是急性卒中临床服务，该服务将确保最大程度的患者转诊，并允许及时快速识别、筛选和招募潜在的研究受试者，以研究脑损伤的早期事件并将患者纳入急性卒中研究方案。由于缺乏急诊科以及筛选和招募急性卒中患者作为研究对象的时间限制，NIH临床中心无法作为我们研究项目的主要地点。因此，我们已经建立并维护了支持当地医院、马里兰州贝塞斯达的郊区医院（SH）和华盛顿特区的MedStar华盛顿医院中心（MWHC）的此类计划所需的临床、成像和研究基础设施。这些地点也是我们ACGME认证的血管神经学奖学金培训计划和创伤性脑损伤研究方案招募的关键培训地点。该基础设施的主要组成部分包括NIH卒中服务，由NIH和承包临床医生卒中神经学家、护士、临床研究员、现场研究/护士协调员和MRI技术专家组成。国家卫生研究院的计算机网络已扩展到每个研究中心。此外，NIH在MWHC放置了一台3 T MRI扫描仪，并在SH共享一台3 T MRI扫描仪。我们为MWHC和SH MRI扫描仪上获得的图像维护自己的PACS，并开发和维护临床和研究患者数据的注册表。于过去一年，受新型冠状病毒疫情严重影响。 虽然临床团队继续为急性中风提供护理，但由于COVID-19大流行，研究招募暂停约6个月。

The foundation of an acute stroke research program is an acute stroke clinical service that will assure maximum patient referral and allow rapid identification, screening and recruitment of potential research subjects in the timely fashion needed to study the early events in cerebral injury and enroll patients in acute stroke research protocols. Absence of an emergency department and the time constraints on screening and recruitment of acute stroke patients as research subjects has precluded the NIH Clinical Center as the main site of our research projects. Thus, we have established and maintained the clinical, imaging and research infrastructure required to support such a program at local hospitals, Suburban Hospital (SH) in Bethesda, Maryland, and MedStar Washington Hospital Center (MWHC) in DC. These sites also serve as the key training locations for our ACGME accredited vascular neurology fellowship training program and for recruitment into the traumatic brain injury research protocols. The major elements of this infrastructure include the NIH Stroke Service, a combination of NIH and contractor clinicians stroke neurologists, nurses, clinical fellows, on-site research/nurse coordinators and MRI technologists. The NIH computer network has been extended to each site. In addition NIH has placed a 3T MRI scanner at MWHC and shares a 3T MRI scanner at SH. We maintain our own PACS for images obtained on the MWHC and SH MRI scanners, and developed and maintain a registry for clinical and research patient data. In the past year was severely impacted by the coronavirus pandemic. While the clinical team continued to provide care for acute stroke, enrollment into research was paused for approximately 6 months due to COVID-19 pandemic.