催乳素分泌的调节-猫眼课题宝

催乳素分泌的调节

批准号：

8606455

负责人：

Richard Bertram

金额：

$43.11万

依托单位：

FLORIDA STATE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

1992

资助国家：

美国

项目状态：

已结题

起止时间：

1992-05-01 至 2016-01-31

来源：

https://reporter.nih.gov/project-details/8606455

关键词：

Address Adverse effects Affect Angiotensin II Anterior Pituitary Gland Behavior Benign Biological Blood Bromocriptine Calcitonin Calcium Calcium Signaling Cell Nucleus Cells Clinical Coupled Data Disease Dopamine Dopamine Agonists Dopamine Receptor Endothelin Environment Estrous Cycle Experimental Designs GTP-Binding Proteins Galanin Hormones Hypothalamic structure Implant Lactation Metabolism Modeling Nature Neurohormones Neurons Neurosecretory Systems Neurotensin Oligonucleotides Organism Osmoregulation Ovarian Oxytocin Pathway interactions Patients Pharmaceutical Preparations Physiological Pituitary Gland Pituitary Neoplasms Population Progress Reports Prolactin Prolactin Release-Inhibiting Hormone Prolactin-Releasing Hormone Prolactinoma Property Rattus Regulation Reporting Reproduction Role Self-control as a personality trait Signal Pathway Signal Transduction Site Social Welfare Staging Steroids Stimulus Structure of nucleus infundibularis hypothalami Substance P Testing Thyrotropin-Releasing Hormone Time Vasoactive Intestinal Peptide Vasopressins base cabergoline desensitization design dopaminergic neuron immune function inhibitor/antagonist insight interdisciplinary approach lactotroph mathematical methods mathematical model model development neuropeptide Y novel prevent public health relevance relating to nervous system release factor research study response suprachiasmatic nucleus

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DESCRIPTION (provided by applicant): The Central Hypothesis of this renewal application is that under physiological conditions, prolactin (PRL) secretion is inhibited by dopamine (DA) and stimulated by oxytocin (OT) and that the activities of these neurons are regulated by higher hypothalamic input and PRL itself. We will test this hypothesis with a novel interdisciplinary experimental and mathematical approach to the following specific aims: (1) To determine the basis for a physiological interaction between DA, OT and PRL secretion, (2) To determine the physiological basis for the estrous cycle stage differences in the response of lactotropes to the PRL-releasing properties of OT, (3) To characterize the mechanism of action of OT on pituitary lactotropes and (4) To characterize the relationship of DA and other modulators of PRL release on OT-induced responses in lactotropes. These aims are significant because they will challenge accepted dogma that PRL secretion in physiological circumstances is only under inhibitory control of hypothalamic DA.

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