Translating discoveries in neurological diseases of infancy and childhood

转化婴儿和儿童神经系统疾病的发现

• 批准号: 8785264
• 负责人: HEATHER J FULLERTON
• 金额: $ 17.72万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8785264
• 关键词: Academic Training; Blood Vessels; Brain; Brain Injuries; Child; Childhood; Childhood stroke; Clinical; Clinical Research; Cognitive; Collaborations; Commit; Coupled; Discipline; Disease; Doctor of Philosophy; Environment; Faculty; Fellowship; Floor; Fostering; Foundations; Goals; Image; Laboratories; Language Development; Language Disorders; Lesion; Mentors; Mission; Neurologist; Neurology; Neurosciences; Pediatric Hospitals; Pediatric Neurology; Phase; Protocols documentation; Psychiatry; Psychologist; Research; Research Methodology; Research Personnel; Scientist; Structure; Testing; Training; Training Programs; Translating; Translational Research; career; career development; infancy; interest; nervous system disorder; neuroimaging; neurosurgery; next generation; outreach; programs; square foot; training project

DESCRIPTION (provided by applicant): The goal of this competing renewal application is to continue to train, with the highest rigor, candidates who will succeed in academic child neurology. At UCSF, we have created a program that combines clinical focus with rigorous postgraduate scientific training. Over the past two decades, the NSADA has provided the foundation for our division of child neurology to grow academically and has allowed us to merge clinical training with scientific discovery. Recent changes at UCSF will further enhance our program. The creation of the UCSF Pediatric Brain Center in 2011 has broken down traditional silos to foster collaboration between clinicians and scientists across disciplines. The 237,000 square foot Sandler Neurosciences Center opened on the UCSF Mission Bay Campus in 2012, bringing investigators in neurology, neurosurgery, and psychiatry together under a single roof. The new UCSF Benioff Children's Hospital will open on the same campus in February, 2015, steps away from the Sandler building, and is already sparking new collaborations on childhood diseases among Sandler investigators. The overall theme of our application is, "Translating discoveries in neurological diseases of infancy and childhood." We will offer rigorous training in research methodology to young investigators with focused clinical expertise who are poised to identify the most pressing research questions in their respective fields within child neurology. Our specific aims are to continue to offer a structured program for training academic child neurologists for a career in translational research; to foster career development, pairing clinical and research interests; to expose candidates to the intellectual environment of UCSF; and to promote diversity in academic child neurology. The planned duration of the program is 5 years; we project training 3 scholars who will be junior faculty having recently completed their clinical subspecialty training. Our first candidate, Kevin Shapiro, MD, PhD, is a child neurologist and cognitive psychologist who is currently completing a vascular neurology fellowship. He will study language development and cortical plasticity after early brain injury using a combination of cognitive testing and multimodal neuroimaging in children with focal ischemic brain lesions. He will benefit from two internationally-recognized mentors: Dr. Maria Luisa Gorno-Tempini, expert in language disorders, and Dr. Heather Fullerton, expert in childhood stroke. He will use Sandler facilities, including the Neuroscience Imaging Center, a state-of-the-art research imaging center on the ground floor of the Sandler Neurosciences Center; his mentors both have their laboratories in the same building. Additional potential candidates will submit protocols for review by the internal and external advisors; we will perform outreach to enhance the diversity of our candidates. With well-established, nationally recognized and supported training programs at UCSF to support the didactic phase of this program, coupled with a team of accomplished mentors committed to the career development of child neurologists, we will succeed in bringing forth the next generation of leaders in academic child neurology.

描述（由申请人提供）：本次竞争更新申请的目标是继续以最高的严谨性培养将在学术儿童神经病学方面取得成功的候选人。在加州大学旧金山分校，我们创建了一个将临床重点与严格的研究生科学训练相结合的项目。在过去的二十年中，NSADA为我们的儿童神经病学部门的学术发展提供了基础，并使我们能够将临床培训与科学发现相结合。加州大学旧金山分校最近的变化将进一步加强我们的项目。2011年，加州大学旧金山分校儿科脑中心的成立打破了传统的藩篱，促进了临床医生和跨学科科学家之间的合作。2012年，占地23.7万平方英尺的桑德勒神经科学中心在加州大学旧金山分校Mission Bay校区开放，将神经病学、神经外科和精神病学的研究人员聚集在一起。新的UCSF贝尼奥夫儿童医院将于2015年2月在同一校园开业，离桑德勒大楼仅几步之遥，并且已经在桑德勒研究人员之间引发了新的儿童疾病合作。我们申请的总体主题是，“转化婴儿和儿童神经系统疾病的发现。”我们将为具有临床专业知识的年轻研究人员提供严格的研究方法培训，这些研究人员准备在儿童神经病学的各自领域确定最紧迫的研究问题。我们的具体目标是继续提供一个结构化的项目，培训学术儿童神经科医生从事转化研究；促进职业发展，配对临床