Biospecimen and Biostatistics Core

由乔安娜·菲利普斯博士领导的生物科学和生物统计核心将提供领导和 支持这项POL拨款中的3个项目的实验室和临床研究所需的专业知识。这个 创建涵盖这两个领域的单一核心的决定反映了使用复杂的 评估组织样本的组织学和基因组特性的方法，以及了解如何 将获得的复杂的多参数数据与活体成像数据的结果相结合。 Biospecimen部分将由Phillips博士领导，他将与 每个项目的负责人确保生物菌种的获取、分配和分析符合 项目的需求。将提供以下资源和服务：工作人员和专门知识 采集、处理和存档图像引导下的脑瘤标本和新鲜脑瘤组织；形态学 和项目所需的相关分子分析；神经病理学专业知识 经过处理的组织切片和适当的定量参数或序数分数的提取；组织 清单和可与成像和临床相关联的相关分子参数的数据库 数据库；以及严格遵守有关知情同意和患者保密的规定， 以及对生物标本和来自生物标本的信息的管理。 生物统计学部分将由Molinaro博士领导，他将与 来自所有三个项目的个人领导人评估他们的统计需求。服务将包括：关于 实验和临床研究的设计，包括计算样本量和能量；数据分析 支持(通过在核心内部进行分析或向项目内的合格人员提供建议)， 开发适当的统计模型并选择有意义的检验；以及在必要时， 开发新的方法来帮助解释实验结果。莫里纳罗博士和她的同事们 参加定期安排的项目会议，提供统计和生物信息学方面的意见 技术方面，以及协助准备材料以供介绍和出版。

The Biospecimen and Biostatistics Core, directed by Dr. Joanna Phillips, will provide the leadership and expertise needed to support the laboratory and clinical research of the 3 Projects in this POl grant. The decision to create a single Core covering these two areas reflects the need for using sophisticated approaches to evaluate the histological and genomic properties of tissue samples, as well to understand how to combine the complex, multi-parametric data obtained with the results from in vivo imaging data. The Biospecimen component will be led by Dr. Phillips, who will interact on an ongoing basis with the leaders of each Project to ensure that the acquisition distribution, and analysis of biospecimens meets the needs of the Projects. The following resources and services will be provided: the staff and expertise to collect, process, and archive image guided brain tumor samples and fresh brain tumor tissue; morphologic and relevant molecular analysis required by the Projects; neuropathologic expertise for interpretation of the processed tissue sections and extraction of appropriate quantitative parameters or ordinal scores; a tissue inventory and a database of associated molecular parameters that can be linked to the imaging and clinical databases; and stringent compliance with regulations governing informed consent and patient confidentiality, as well as management of the biospecimens and the information derived from the biospecimens. The Biostatistical component will be led by Dr. Molinaro, who will interact on an ongoing basis with the individual leaders from all three Projects to assess their statistical needs. Services will include: advice on the design of experimental and clinical studies, including calculating sample sizes and power; data analysis support (either by performing the analyses within the core or advising qualified personnel within the projects), developing appropriate statistical models and selecting tests of significance; and, when necessary, the development of novel methods to help interpret experimental results. Dr.Molinaro and her colleagues will participate in regularly scheduled project meetings to provide input on statistical and bioinformatics techniques, as well as assisting in the preparation of material for presentation and publication.