Biospecimen and Biostatistics Core

生物样本和生物统计学核心

• 批准号: 9317443
• 负责人: Susan M Chang
• 金额: $ 31.19万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-27 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9317443
• 关键词: Animals; Archives; Area; Bioinformatics; Biometry; Biostatistics Core; Brain Neoplasms; Clinical; Clinical Research; Clinical Trials Database; Collection; Complex; Confidentiality of Patient Information; Data; Data Analyses; Databases; Development; Ensure; Equipment and supply inventories; Experimental Designs; Follow-Up Studies; Genomics; Glioblastoma; Goals; Grant; Histologic; Human; Human Resources; Image; Individual; Informed Consent; Instruction; Laboratory Research; Leadership; Link; Maintenance; Methods; Molecular; Molecular Analysis; Morphology; Pathology; Preparation; Procedures; Process; Property; Publications; Regulation; Research Design; Resources; Sample Size; Sampling; Schedule; Services; Statistical Data Interpretation; Statistical Models; Techniques; Testing; Tissue Sample; Tissues; Tumor Tissue; clinically relevant; design; epigenomics; human subject; image archival system; image guided; in vivo imaging; meetings; novel; programs; quality assurance; repository; translational impact; validation studies

The Biospecimen and Biostatistics Core, directed by Dr. Joanna Phillips, will provide the leadership and expertise needed to support the laboratory and clinical research of the 3 Projects in this POl grant. The decision to create a single Core covering these two areas reflects the need for using sophisticated approaches to evaluate the histological and genomic properties of tissue samples, as well to understand how to combine the complex, multi-parametric data obtained with the results from in vivo imaging data. The Biospecimen component will be led by Dr. Phillips, who will interact on an ongoing basis with the leaders of each Project to ensure that the acquisition distribution, and analysis of biospecimens meets the needs of the Projects. The following resources and services will be provided: the staff and expertise to collect, process, and archive image guided brain tumor samples and fresh brain tumor tissue; morphologic and relevant molecular analysis required by the Projects; neuropathologic expertise for interpretation of the processed tissue sections and extraction of appropriate quantitative parameters or ordinal scores; a tissue inventory and a database of associated molecular parameters that can be linked to the imaging and clinical databases; and stringent compliance with regulations governing informed consent and patient confidentiality, as well as management of the biospecimens and the information derived from the biospecimens. The Biostatistical component will be led by Dr. Molinaro, who will interact on an ongoing basis with the individual leaders from all three Projects to assess their statistical needs. Services will include: advice on the design of experimental and clinical studies, including calculating sample sizes and power; data analysis support (either by performing the analyses within the core or advising qualified personnel within the projects), developing appropriate statistical models and selecting tests of significance; and, when necessary, the development of novel methods to help interpret experimental results. Dr.Molinaro and her colleagues will participate in regularly scheduled project meetings to provide input on statistical and bioinformatics techniques, as well as assisting in the preparation of material for presentation and publication.

生物标本和生物统计学核心，由乔安娜菲利普斯博士指导，将提供领导， 专业知识需要支持的实验室和临床研究的3个项目在这个POI赠款。的 决定建立一个单一的核心，涵盖这两个领域反映了需要使用复杂的 评估组织样本的组织学和基因组特性的方法，以及了解如何 以将获得的复杂的多参数数据与来自体内成像数据的结果联合收割机组合。 生物样本部分将由菲利普斯博士领导，他将与 各项目负责人确保生物标本的采集、分发和分析符合 项目的需要。将提供以下资源和服务： 收集、处理和存档图像引导的脑肿瘤样本和新鲜脑肿瘤组织;形态学 以及项目所需的相关分子分析; 处理的组织切片和提取适当的定量参数或顺序评分;组织 库存和相关分子参数的数据库，其可以与成像和临床 数据库;以及严格遵守关于知情同意和患者保密的法规， 以及生物样本和从生物样本得到的信息的管理。 生物统计部分将由Molinaro博士领导，他将持续与 所有三个项目的个别领导人评估他们的统计需求。服务将包括： 实验和临床研究设计，包括计算样本量和把握度;数据分析 支持（通过在核心内进行分析或向项目内的合格人员提供咨询）， 开发适当的统计模型和选择显著性检验;必要时， 开发新的方法来帮助解释实验结果。莫利纳罗博士和她的同事们将 参加定期举行的项目会议，就统计和生物信息学提供投入 技术，以及协助编写材料，介绍和出版。