UCLA Los Angeles Brazil AIDS Consortium

加州大学洛杉矶分校洛杉矶分校巴西艾滋病联盟

• 批准号: 8787195
• 负责人: Yvonne J. Bryson
• 金额: $ 84.41万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8787195
• 关键词: AIDS clinical trial group; Acquired Immunodeficiency Syndrome; Adolescent; Adult; Brazil; Caring; Catchment Area; Child; Clinical Trials; Clinical Trials Unit; Community Outreach; Complex; County; Data; Data Quality; Economics; Enrollment; Funding; HIV; HIV prevention trial; Hospitals; IMPAACT; Infant; Laboratories; Leadership; Los Angeles; Mentors; Oranges; Patients; Pediatric Hospitals; Perinatal; Phase; Population Heterogeneity; Pregnant Women; Publications; Records; Research Infrastructure; Risk; Site; United States National Institutes of Health; Universities; clinical research site; cohort; experience; pediatric AIDS; pediatric human immunodeficiency virus; success

DESCRIPTION (provided by applicant): UCLA has been NIH funded as a Pediatric AIDS Clinical Trials Unit for Los Angeles since its inception in1988 and as a HIV Prevention Trials Unit for Brazil since 2000. We propose the UCLA LA/BRAZIL AIDS consortium CTU (UCLA-LABAC-CTU) with 5 domestic sites in LA participating as a consortium affiliated with IMPAACT and 5 Brazilian sites participating in multiple networks (IMPAACT, HPTN and AACTG). The proposed UCLA CTU-affiliated clinical sites were chosen as preferred sites by the respective networks (IMPAACT, HPTN, AACTG) by independent reviewers and network leadership. Our specific aims include enrolling significant numbers of HIV infected and at risk infants, children, adolescents and adults into high priority clinical trials associated with NIH networks, contributing to the NIH scientific agenda, maintaining administrative and financial, scientific and data, regulatory and laboratory oversight of affiliated CRS and maintaining and expanding our community outreach and CAB. The LA consortium includes UCLA, Long Beach Memorial, Harbor-UCLA, Children's Hospital LA and Children's Hospital Orange County. This consortium is the major catchment area for geographically and ethnically diverse population (>1000 HIV-exposed / infected children / adolescents and >150 HIV-infected pregnant women/year. UCLA has functioned as the main administrative, data entry, laboratory, CAB and mentor for the group. This resulted insignificant success in clinical trials experience and economic efficiency. Since 1989 we unrolled 826 patients in 71 phase I, II & III perinatal pediatric HIV trials, with excellent retention, data quality and publication records. In Brazil, our group includes HSE hospital in Rio, 3 sites in Porto Alegre, (Concoicao, Santa Casa and Femina Hospitals), and 1 in Sao Paulo (Federal University). All are established UCLA-HPTN sites and 2are also PACTG and AACTG sites. These sites have enrolled >900 subjects in clinical trials (265 enrolled inHPTN040 MTCT). Five other NIH-sponsored trials are being initiated this year. All Brazil CRS propose affiliation with IMPAACT and 2 with the AACTG and HPTN. These sites care for 1700 HIV infected children,900 adolescents, 800 pregnant women, and the AACTG sites have 4,700 infected adults and access to large cohorts of at risk seronegative adults. The LABAC CTU and CRS are successful units with the infrastructure and experience needed for the conduct of both complex and multicenter NIH Network trials. ADMINISTRATIVE COMPONENT:

描述（由申请人提供）：UCLA自1988年成立以来一直是洛杉矶的儿科艾滋病临床试验部门，自2000年以来作为巴西的HIV预防试验部门。巴西站点参与多个网络（Incract，HPTN和AACTG）。独立的审阅者和网络领导力各自的网络（Impaact，hptn，aactg）选择了拟议的UCLA CTU相关临床站点作为首选站点。我们的具体目的包括在与NIH网络相关的高优先临床试验中注册大量的艾滋病毒感染和危险的艾滋病毒和处于风险的艾滋病毒，为NIH科学议程做出了贡献，维持行政和财务，科学和数据，监管和实验室，监管和实验室的监管，对分支机构CRS和我们的社区和驾驶和驾驶和驾驶和驾驶和驾驶和驾驶和驾驶和驾驶。洛杉矶财团包括加州大学洛杉矶分校，长滩纪念馆，苏联港口，洛杉矶儿童医院和橙县儿童医院。该财团是地理和种族多样化人群的主要流水区（> 1000个受HIV暴露 /感染的儿童 /青少年，> 150名受HIV感染的孕妇 /年。加州大学洛杉矶分校（UCLA）作为该小组的主要行政，数据进入，实验室，驾驶室和导师的主要行政，实验室，驾驶室和驾驶员的经验。这在临床效率和经济效率上是不合时宜的。 III在巴西的小儿艾滋病毒试验，包括在里约热内卢的HSE医院，包括在巴西的HSE医院，Concoicao，Santa Casa和Femina Hospitals的3个地点）和Sao Paulo Site and Sities and Sities和2 Arec。临床试验的受试者（265个招募的INHPTN040 MTCT）。这些地点护理1700名受艾滋病毒感染儿童，900名青少年，800名孕妇和AACTG地点有4,700名受感染的成年人，并获得大量的AT风险血清染色成年人。 Labac CTU和CRS是成功进行基础架构和经验的成功单位，用于进行复杂和多中心NIH网络试验。 管理组件：