PEDIATRIC LATE OUTCOMES PROTOCOL (ACTG 219C)

儿科晚期结果方案 (ACTG 219C)

• 批准号: 7606740
• 负责人: Yvonne J. Bryson
• 金额: $ 0.33万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-21 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606740
• 关键词: AIDS clinical trial group; Adolescent; Anti-Retroviral Agents; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Evaluation; Exposure to; Funding; Grant; Growth; Immunologics; Immunotherapy; Infant; Institution; Laboratories; Malignant Neoplasms; Metabolic Diseases; Neurologic; Neuropsychology; Opportunistic Infections; Outcome; Perinatal; Protocols documentation; Puberty; Quality of life; Research; Research Personnel; Resources; Source; Time; Toxic effect; United States National Institutes of Health; Vaccine Therapy; Woman; antiretroviral therapy; body system; in utero; infancy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To primary objectives are 1) to describe late outcomes over time in relation to survival, growth, neurologic and neuropsychologic function, quality of life, organ system toxicity, metabolic disorders, development of opportunistic infections and malignancies, and immunologic, and virologic parameters in HIV-infected infants, children, and adolescents. This will also include evaluation of potential late outcomes, impact of puberty, and complications of antiretroviral and immune therapy received by the subject. 2)to determine if uninfected infants born to HIV-infected women demonstrate any short or long term adverse clinical or laboratory effects due to exposure to antiretroviral therapy or immune therapy/vaccines in utero, the perinatal period, or early infancy.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 主要目的是：1）描述HIV感染婴儿、儿童和青少年的生存、生长、神经和神经心理功能、生活质量、器官系统毒性、代谢紊乱、机会性感染和恶性肿瘤的发生以及免疫学和病毒学参数随时间推移的晚期结局。 这还将包括评价受试者接受的抗逆转录病毒和免疫治疗的潜在晚期结局、青春期影响以及并发症。2）确定HIV感染妇女所生的未感染婴儿是否因在子宫内、围产期或婴儿早期暴露于抗逆转录病毒治疗或免疫治疗/疫苗而表现出任何短期或长期不良临床或实验室影响。