Schiff base forming sunscreen filters for long-wear UV protection

描述（由申请人提供）：根据美国癌症协会的说法，降低非黑色素瘤皮肤癌风险的最佳方法是通过使用广谱防晒霜“实践阳光安全”。商用紫外线（UV）过滤器的一个主要限制是它们与人体皮肤缺乏亲和力，很容易被水、汗水和正常佩戴去除。因此，消费者必须不断地重新涂抹防晒霜以获得充分的保护效果。产品及长远目标：Nanometics公司对二氧化钛和氧化锌颗粒进行了改性，开发出长时间使用的紫外线防晒过滤器。新的紫外线过滤器是由廉价的商业原料合成的，将作为粉末在全球销售，作为各种皮肤产品的长期使用成分。预计这些紫外线过滤器将减轻不断重复使用产品的需要。技术创新：一种天然存在的抗氧化配体被吸附在防晒级TiO2或ZnO的表面，并作为异双功能连接体，将紫外线过滤器与皮肤共价结合。预计这些

DESCRIPTION (provided by applicant): According to the American Cancer Society, the best way to lower the risk of non-melanoma skin cancer is "to practice sun safety" by applying broad-spectrum sunscreens. A major limitation of commercial Ultraviolet (UV) filters is that they lack affinity with human skin and are easily removed by water, perspiration, and normal wear. Consequently, the consumer must continually reapply sunscreen to gain full protective benefit. Product and Long-Term Goal: Nanometics has modified TiO2 and ZnO particles to develop long-wear UV sunscreen filters. The new UV filters are synthesized from inexpensive commercial starting materials and will be sold globally as powders for incorporation as long-wear ingredients in a variety of dermatological products. It is anticipated that these UV filters wll alleviate the need for constant product reapplication. Technical Innovation: A naturally occurring anti-oxidant ligand is adsorbed onto the surface of sunscreen grade TiO2 or ZnO and utilized as a heterobifunctional linker to covalently bond UV filters to the skin. It is anticipated that these new UV filters will exhibit enhanced water-resistance when delivered to the skin and provide long-wear protection from UV radiation. Phase I Outcomes: Phase I SBIR studies were designed to demonstrate the feasibility of modified TiO2 and ZnO particles as long-wear UV filters and de-risk the technology for the more cost-intensive Phase II SBIR studies. Preliminary in vitro and in vivo studies have demonstrated that adsorption of the heterobifunctional linker does not negatively influence the photo-protective properties or safety profile of the particles. Phase II Hypotheses: (1) Modified TiO2 and ZnO particles will be water-resistant for at least 80 minutes when evaluated in a human clinical sun protection factor assay; (2) adsorption of the heterobifunctional linker does not enhance the dermal penetration profile of the particles; and (3) a cost-effective protocol to commercial- scale quantities of modified particles will be developed. Commercial Opportunity: The global market size for UV filters is estimated to exceed $650 million by 2018. Contingent upon successful completion of the milestones in this proposal, Nanometics will commercialize PLP- Particles as novel inorganic UV filters to be sold globally as ingredients for dermatological products.