The Development of Inorganic Ultraviolet Filters Exhibiting Improved Topical Retention on Human Skin for The Prevention of Skin Cancer
无机紫外线滤光剂的开发可改善人体皮肤的局部保留,从而预防皮肤癌
基本信息
- 批准号:10080275
- 负责人:
- 金额:$ 100万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-18 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:AffinityAldehydesAmericanAwardBiological SciencesBiotechnologyCellsChemistryCutaneousDermalDevelopmentDiagnosisEvaluationExcisionExhibitsFormulationGoalsHealthcareHumanImmersionIncidenceKilogramKnowledgeLaboratoriesLegal patentLinkMalignant NeoplasmsMarket ResearchMediatingModificationOutcomePenetrationPerformancePhasePhototoxicityPreventive measureProceduresProcessProteinsReapplicationReproducibilityResistanceRiskRisk FactorsSafetySamplingSchiff BasesSelf CareSkinSkin CancerSmall Business Innovation Research GrantSoapsSunlightSunscreening AgentsSurfaceTechnologyTimeToxic effectUV Radiation ExposureUV protectionUltraviolet RaysUnited StatesWaterZinc Oxidealkalinitycancer carecommercial applicationcovalent bonddesignhealthy volunteerimprovedinterestnovelphase 1 studypreventskin cancer preventionskin organogenesissuccesstechnological innovationtitanium dioxideultravioletultraviolet damagevolunteer
项目摘要
PROJECT SUMMARY / ABSTRACT
This Phase II project is predicated on the NCI Phase I award 1R43CA236265-01 and is a resubmission.
Problem to be Solved and Significance: Exposure to Ultraviolet radiation (UVR) is a risk factor for the
development of skin cancer, and health care agencies recommend that sunscreens be used as a preventative
measure. A major limitation of commercial sunscreens is the need to continually reapply to gain full benefit.
This is because sunscreens contain UV filters that lack affinity with skin and are easily removed by normal
wear. The development of durable filters with improved retention on skin has the potential to mitigate UV-
mediated toxicities and remains a significant priority. Product and Long-Term Goal: Nanometics (d.b.a. PHD
Biosciences [PHD]) is developing novel titanium dioxide and zinc oxide UV filters that contain a coating that
interacts with skin proteins to improve topical retention time for up to 160 min. The novel UV filters are as
photoprotective and safe as commercial UV filters and readily synthesized from inexpensive starting materials.
They will be sold globally as ingredients for sunscreens and other topical products. It is anticipated that these
UV filters will alleviate the need for constant product reapplication. Technological Innovation: The surface of
commercial titanium dioxide and zinc oxide UV filters is covalently modified to contain a coating that interacts
with skin proteins to improve topical retention time. The coating is designed to form a stable interaction at skin
pH and can easily be removed by washing with soap and water. Specific Aim #1 Demonstrate that
modification with HPGA does not influence the dermal penetration profile of the UV filters when
evaluated on human skin explants. In this aim the dermal penetration profile of HPGA-Filters on cultured
human skin will be investigated. Success Criterion: This aim will be successful upon determining that the
HPGA-Filters do not penetrate to viable skin cells after a 48 h evaluation period. Specific Aim #2. Scale the
chemistry, manufacturing and control processes to produce the HPGA-Filters on 75 kilogram batch
sizes. The chemistry, manufacturing, and control (CMC) processes to produce HPGA-Filters in 75 kg batch
sizes will be developed. Success Criterion: This aim will be successful upon optimizing the procedure to
produce materials at 75 kg batch sizes with reproducible analytical profile and stability. Commercial
Opportunity: The global market for UV filters is estimated to exceed $650 million by 2019. Phase II SBIR
studies will include additional studies to confirm the safety on a larger number of volunteers; examine the
performance against leading commercial sunscreens; and optimize the chemistry, manufacturing, and control
(CMC) processes to produce the filters in multi-kilogram quantities. The technology is covered by a pending
patent that protects the PHD commercial and development interests.
项目总结/摘要
该第二阶段项目是基于NCI第一阶段奖励1 R43 CA 236265 -01的,是重新提交的。
待解决的问题及意义:紫外线辐射(UVR)暴露是一个危险因素,
皮肤癌的发展,卫生保健机构建议使用防晒霜作为预防措施,
measure.商业防晒霜的一个主要限制是需要不断地重新应用以获得全部益处。
这是因为防晒霜含有紫外线过滤剂,与皮肤缺乏亲和力,很容易被正常的皮肤去除。
穿.开发持久的过滤器,改善皮肤上的保留,有可能减轻紫外线,
介导的毒性,仍然是一个重要的优先事项。产品和长期目标:纳米技术(d.b.a.博士
Biosciences [PHD])正在开发一种新型的二氧化钛和氧化锌紫外线过滤剂,
与皮肤蛋白相互作用,可延长局部保留时间长达160分钟。
光保护性和安全性作为商业紫外线过滤剂,并容易从廉价的原料合成。
它们将作为防晒霜和其他局部产品的成分在全球销售。预计这些
紫外线过滤剂将减少产品重复使用的需要。技术创新:表面
市售的二氧化钛和氧化锌UV滤光剂被共价改性以包含涂层,
与皮肤蛋白质,以改善局部保留时间。该涂层旨在与皮肤形成稳定的相互作用
pH值,可以很容易地用肥皂和水清洗。具体目标#1证明
用HPGA改性不影响UV过滤剂的皮肤渗透特性,
在人体皮肤移植物上进行评估。在这个目标中,HPGA-过滤器对培养的
将研究人类皮肤。成功的标准:这个目标将是成功的,一旦确定,
HPGA-过滤器在48小时评价期后不渗透到活的皮肤细胞。具体目标#2缩放
化学、制造和控制过程,以生产75千克批量的HPGA过滤器
尺寸.生产75 kg批次HPGA过滤器的化学、生产和控制(CMC)工艺
尺寸将得到发展。成功标准:此目标将在优化程序后成功,
以75 kg批量生产具有可重现分析特征和稳定性的材料。商业
机会:到2019年,全球紫外线过滤器市场估计将超过6.5亿美元。第二阶段SBIR
研究将包括额外的研究,以确认更多志愿者的安全性;检查
性能领先的商业防晒霜;并优化化学,制造和控制
(CMC)生产数公斤数量的过滤器的工艺。该技术涵盖了一个悬而未决的
保护博士商业和发展利益的专利。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Steven Isaacman', 18)}}的其他基金
A Phase 2, randomized, double-blind, 4-arm, multicenter study to demonstrate the efficacy and safety of topical dosage formulations of a prescription drug product for actinic keratosis
一项 2 期、随机、双盲、4 组、多中心研究,旨在证明处方药局部剂量制剂治疗光化性角化病的有效性和安全性
- 批准号:
10820810 - 财政年份:2023
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Furthering the clinical development of a first in class, water resistant sunscreen to meet emerging environmental regulations
推进一流防水防晒霜的临床开发,以满足新兴的环境法规
- 批准号:
10255409 - 财政年份:2021
- 资助金额:
$ 100万 - 项目类别:
The Development of Inorganic Ultraviolet Filters Exhibiting Improved Topical Retention on Human Skin for The Prevention of Skin Cancer
无机紫外线滤光剂的开发可改善人体皮肤的局部保留,从而预防皮肤癌
- 批准号:
10202504 - 财政年份:2018
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A targeted immunomodulator for the treatment of acute sickle crisis
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8979976 - 财政年份:2015
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Orally available transition state inhibitors for triple negative breast cancer
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8646623 - 财政年份:2014
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Schiff base forming sunscreen filters for long-wear UV protection
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- 批准号:
8833063 - 财政年份:2012
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Schiff base forming sunscreen filters for long-wear UV protection
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8392787 - 财政年份:2012
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