Schiff base forming sunscreen filters for long-wear UV protection

席夫碱成型防晒滤光片，可提供长效紫外线防护

• 批准号: 8392787
• 负责人: Steven Isaacman
• 金额: $ 25.05万
• 依托单位: NANOMETICS, LLC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8392787
• 关键词: Accounting; Adsorption; American Cancer Society; Amines; Antioxidants; Basal cell carcinoma; Biotechnology; Caring; Clinical; Cosmetics; Development; Disadvantaged; Drug Formulations; Epidermis; Esthetics; Exhibits; Exposure to; Goals; Grant; Healthcare; Human; In Vitro; Industry; Knowledge; Legal patent; Letters; Ligands; Link; Malignant Neoplasms; Marketing; Measures; Methods; Modeling; Phase; Polymers; Powder dose form; Preparation; Property; Pyridoxal Phosphate; Reapplication; Reporting; Research; Research Proposals; Resistance; Risk; Risk Factors; Safety; Schiff Bases; Skin; Skin Cancer; Skin Carcinoma; Skin Care; Small Business Innovation Research Grant; Sunscreening Agents; Surface; System; Technology; Testing; The Sun; Toxic effect; UV protection; Ultraviolet B Radiation; Ultraviolet Rays; United States; Vitamin B6; Water; Zinc Oxide; cancer care; commercial application; commercialization; covalent bond; cytotoxic; cytotoxicity; design; improved; in vivo; in vivo Model; innovation; medical specialties; metal oxide; novel; particle; radiation effect; skin cancer prevention; success; technological innovation; titanium dioxide; ultraviolet

DESCRIPTION (provided by applicant): Problem to be solved: Skin cancer is the most common of all cancers, accounting for nearly half of all reported cancer cases in the USA. According to the American Cancer Society (ACS), the best way to lower the risk of non-melanoma skin cancer is "to practice sun safety" by applying broad-spectrum sunscreens. One major disadvantage of commercial sunscreens is that the filters lack substantively with the skin and are easily removed by normal wear. As a consequence, the consumer must constantly reapply the sunscreen to benefit from the protection offered by the product. Product and Long-Term Goal: Nanometics has developed coated inorganic sunscreen filters that form temporary bonds with the epidermis, providing for long-wear protection from UV radiation. The filters are useful as ingredients in topical delivery systems and we anticipate that these filters will alleviae the need for constant product reapplication. The novel filters will be sold globally as powders and specialty dispersions, to be incorporated as long-wear ingredients in topical formulas. Technical Innovation: A naturally occurring anti-oxidant ligand, adsorbed to the surface of sunscreen grade TiO2 and ZnO particles, acts as a hetero bifunctional linker and forms temporary covalent bonds with epidermal amines, chemically "linking" the particles to the skin. Preliminary results have demonstrated that the novel particles exhibit water resistant properties. Thus far we have demonstrated the preliminary safety of these particles in a human clinical panel and their utility in an established in vitro skin model. Phase I Hypothesis: The Phase I hypothesis is that adsorption of the ligand onto the sunscreen filter does not negatively impact (1) the breadth and magnitude of UV protection and will not (2) increase the cytotoxicity or photogenotoxicity of the particles. Specific Aims: The specific aims of this Phase I SBIR are to (1) determine the particles breadth of UV protection in vitro and magnitude of UV protection in a human panel and (2) To determine the cytotoxic and photogenotoxic potential of the particles in vitro. Phase II: Phase II SBIR studies will focus on optimizing the long-wear attributes of the particles in vivo and demonstrating the complete toxicological profile of these particles in established models. Commercial Opportunity: The sun care market is estimated to represent 13.30% of the $9.7 billion domestic skin care market. As the public becomes more educated about the dangers of UV exposure, the sun care market is expected to grow more rapidly than other segments. Discussions with executives at cosmetic companies (Avon, Estee Lauder) indicate a need for long-wear sunscreen filters that are substantive on human skin. PUBLIC HEALTH RELEVANCE: Skin cancers, such as squamous and basal cell carcinomas, represent the most common form of cancer in the United States. Exposure to ultraviolet (UV) light is a known risk factor for the development of skin cancer and health care agencies recommend that topical sunscreens be used as preventative measures against UV exposure. This project seeks to advance the use of long-wear sunscreen filters that will protect the consumer from the harmful effects of radiation, without the need for constant reapplication.

描述（由申请人提供）：要解决的问题：皮肤癌是所有癌症中最常见的，占美国所有报告的癌症病例的一半。根据美国癌症协会（ACS）的数据，降低非黑色素瘤皮肤癌风险的最佳方法是通过施加广谱防晒霜“实践太阳安全”。商业防晒霜的一个主要缺点是，过滤器的皮肤缺乏，并且可以通过正常磨损轻松去除。结果，消费者必须不断重新涂抹防晒霜，以从产品提供的保护中受益。产品和长期目标：纳米学开发了涂层的无机防晒过滤器，与表皮形成临时键，从而为紫外线辐射提供了长装保护。这些过滤器在局部输送系统中作为成分很有用，我们预计这些过滤器将减轻持续的产品重新施法的需求。新颖的过滤器将以粉末和特种色散为全球出售，并将其作为局部配方中的长装成分掺入。技术创新：一种天然存在的抗氧化剂配体，吸附在防晒级TiO2和ZnO颗粒表面上，充当异性双功能连接器，并与表皮胺形成临时的共价键，从化学上将粒子链接到皮肤上。初步结果表明，新型颗粒具有防水性能。到目前为止，我们已经证明了这些颗粒在人类临床面板中的初步安全性及其在已建立的体外皮肤模型中的效用。第一阶段假设：I期假设是，配体在防晒过滤器上的吸附不会对（1）紫外线保护的宽度和幅度，并且不会（2）增加颗粒的细胞毒性或光生毒素。具体目的：该阶段I SBIR的具体目的是（1）在人体面板中确定体外和紫外线保护的紫外线保护的颗粒宽度，以及（2）确定体外颗粒的细胞毒性和光生毒性潜力。第二阶段：II期SBIR研究将重点放在优化体内颗粒的长装属性，并在既定模型中证明这些颗粒的完整毒理学特征。商业机会：据估计，日晒市场占97亿美元家庭护肤市场的13.30％。随着公众对紫外线暴露危险的教育程度更高，预计太阳护理市场将比其他细分市场更快增长。与化妆品公司（Avon，Estee Lauder）的高管讨论表明，需要对人类皮肤实质性的长装防晒霜。 公共卫生相关性：皮肤癌，例如鳞状和基底细胞癌，代表了美国最常见的癌症形式。暴露于紫外线（UV）光是皮肤癌和卫生保健机构发展的已知危险因素，建议将局部防晒霜用作防止紫外线暴露的预防措施。该项目旨在提高使用长装防晒过滤器，以保护消费者免受辐射的有害影响，而无需持续重新涂抹。