Breathing and Walking Coupling Variability in COPD

慢性阻塞性肺病 (COPD) 的呼吸和行走耦合变异

• 批准号: 8663410
• 负责人: Jennifer M Yentes
• 金额: $ 18.98万
• 依托单位: UNIVERSITY OF NEBRASKA OMAHA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8663410
• 关键词: Accounting; Address; Adult; Age; Aging; Auditory; Biological; Cerebral Palsy; Clinic; Cognitive; Complex; Cues; Data; Disease; Elderly; Ensure; Environment; Evidence based practice; Exhibits; Fractals; Future; Gait; Gait abnormality; Genetic Crossing Over; Glass; Goals; Human; Impairment; Independent Living; Individual; Injury; Long-Term Effects; Methods; Motor; Movement; Multiple Sclerosis; Outcome; Parkinson Disease; Patient Education; Patients; Pattern; Performance; Persons; Physiological; Population; Principal Component Analysis; Property; Psychosocial Factor; Reaction; Rehabilitation therapy; Reporting; Research; Running; Series; Solutions; Speed; Stimulus; Stroke; Structure; System; Testing; Time; Training; Training Programs; Traumatic Brain Injury; Visual; Walking; Work; base; cost; cost effective; design; experience; fall risk; falls; fear of falling; flexibility; improved; innovation; mathematical theory; millisecond; neuromuscular system; novel; prevent; programs; research study; restoration; theories; tool; visual stimulus; young adult

Healthy gait exhibits natural stride-to-stride fluctuations that over large series of observations reveal a particular order or structure. This phenomenon is referred to as "physiological complexity". This complexity is thought to be beneficial to the locomotor system as it allows for optimal adaptability, while also ensuring stable, coherent movement, both of which are required to safely navigate realworid, dynamic environments. Walking to an invariant external stimulus as it is the case in current gait rehabilitation leads to a breakdown of this critical property of gait, as it contains no complexity and is purely periodic. We propose a novel variable visual stimulus that reflects the natural variability observed in healthy gait. The stimulus is based on the theory of fractals, meaning it is not simply a randomly variable stimulus. Rather, it has a certain repeated pattern contained within a varying temporal structure, mirroring healthy gait. We propose that this design provides optimal stability and flexibility to the neuromuscular system. In Aim 1, we will carry out an experiment in older adults to consolidate the theory that complexity in gait predicts a person's ability to adapt to internal and external perturbations. In Aims 2 and 3, we will determine the short- and long-term effects of walking in time to the variable visual stimulus on the gait of older adults who are at risk of falls due to poor gait performance. Our preliminary data has shown that the complex structure of gait variability is altered in older adults, but can be restored to levels similar to young adults when they are exposed to a variable external stimulus. We aim to investigate the long-term and retention effects of training with this stimuli (compared to training with an invariant or a completely random visual stimulus) on the restoration of optimal gait variability. We expect that our findings will confirm the efficacy of the proposed variable visual stimulus by positively influencing falls risk and function in older adults, thereby revealing a simple, low-cost therapy that could potentially enable them to remain independent for longer. The longer term goal of our research is. to apply this novel stimulus, and the innovative theoretical framework on which it is based, to all populations that experience gait impairments due to injury (e.g. post-operatively) or disease (e.g. stroke).

健康的步态表现出自然的步幅波动，通过大量的系列观察揭示了 特定的顺序或结构。这种现象被称为“生理复杂性”。这种复杂性是 被认为对运动系统有利，因为它允许最佳的适应性，同时还确保 稳定、连贯的运动，这两者都是在真实、动态的环境中安全导航所必需的。 行走到一个不变的外部刺激，就像目前步态康复中的情况一样，会导致崩溃 步态的这一关键属性，因为它不包含复杂性，并且纯粹是周期性的。我们提议写一部小说 反映在健康步态中观察到的自然可变性的可变视觉刺激。刺激计划的基础是 分形论，这意味着它不是简单的随机变量刺激。相反，它有一定的重复 包含在不同的时间结构中的模式，反映了健康的步态。我们建议这个设计 为神经肌肉系统提供最佳的稳定性和灵活性。在目标1中，我们将开展 在老年人身上进行实验，以巩固步态复杂性预测一个人的适应能力这一理论 对内部和外部的干扰。在目标2和目标3中，我们将确定 老年人因贫穷而有跌倒风险的步态上的可变视觉刺激的及时行走 步态表演。我们的初步数据显示，步态可变性的复杂结构在 老年人，但当他们暴露在变量中时，可以恢复到与年轻人相似的水平 外部刺激。我们的目标是调查使用这种刺激进行训练的长期和保留效果。 (与具有不变或完全随机视觉刺激的训练相比)关于恢复最优 步态可变性。我们期望我们的发现将证实所提出的可变视觉刺激的有效性 通过积极影响老年人的跌倒风险和功能，从而揭示了一种简单、低成本的治疗方法 这可能会使他们在更长时间内保持独立。我们研究的长期目标是。 将这一新的刺激措施及其所基于的创新理论框架应用于所有人口 因受伤(如手术后)或疾病(如中风)导致步态受损的患者。