Reversal of Myocardial Infarction by Localized Stimulation

通过局部刺激逆转心肌梗塞

基本信息

  • 批准号:
    8803093
  • 负责人:
  • 金额:
    $ 50.66万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-08-01 至 2016-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Heart attacks (i.e. myocardial infarction or MI) occur in more than 1.2 million patients annually. Advances in pharmacological therapy have dramatically improved survival following the initial MI. Consequently, the number of patients with previous MI continues to increase, and as a result, put in jeopardy millions of patients for development of heart failure. In these patients with a previous MI, despite optimal standard-of-care, a scar can form in the portion of the heart muscle (myocardium) that was injured from the MI. Formation of a myocardial scar following MI is associated with a malignant remodeling process with respect to changes in the structure and shape of the MI region (infarct expansion). This adverse remodeling after MI can lead to increased morbidity and mortality in these patients. Unfortunately, there are no current pharmacological / therapeutic means to specifically target the myocardial scar as a means to halt and/or reverse the adverse remodeling post-MI. The technology to be advanced in this application directly addresses this unmet medical need by expanding previously performed proof-of-concept studies whereby localized high frequency stimulation (LHFS) beneficially altered the course of post-MI myocardial remodeling. This fast track technology transfer application is intended to move forward the LHFS technology by finalizing the prototype of this technology, and then optimizing efficacy of this technology in a preclinical animal model of MI. These studies will be undertaken in two phases: Phase I: optimize electrical stimulation parameters for LHFS using a validated in vitro test bed, and Phase II: in vivo testing of a selected LHFS device in a preclinical large animal model of MI. The outcomes from these combined Phase I / Phase II projects will move the LHFS technology to establish readiness for clinical feasibility studies.
描述(由申请人提供):心脏病发作(即心肌梗死或MI)每年发生在120多万患者中。药物治疗的进步极大地提高了初次心肌梗死后的生存率。因此,既往心肌梗死患者的数量继续增加,结果使数百万患者处于发展为心力衰竭的危险之中。在这些既往发生心肌梗死的患者中,尽管采用了最佳的标准治疗,但心肌损伤部分(心肌)仍可能形成疤痕。心肌梗死后心肌疤痕的形成与心肌区域结构和形状改变(梗死扩张)的恶性重塑过程有关。心肌梗死后的不良重构可导致这些患者的发病率和死亡率增加。不幸的是,目前还没有专门针对心肌疤痕的药物/治疗手段来阻止和/或逆转心肌梗死后的不良重构。通过扩展先前进行的概念验证研究,局部高频刺激(LHFS)有益地改变心肌梗死后心肌重构的过程,该应用中的先进技术直接解决了这一未满足的医疗需求。这项快速通道技术转移申请旨在通过最终确定该技术的原型来推进LHFS技术,然后优化该技术在心肌梗死临床前动物模型中的功效。这些研究将分两个阶段进行:第一阶段:使用经过验证的体外试验台优化LHFS的电刺激参数,第二阶段:在临床前大型心肌梗死动物模型中对选定的LHFS设备进行体内测试。这些I / II期联合项目的结果将推动LHFS技术为临床可行性研究做好准备。

项目成果

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FRANCIS G SPINALE其他文献

FRANCIS G SPINALE的其他文献

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{{ truncateString('FRANCIS G SPINALE', 18)}}的其他基金

Fibroblast targeting for myocardial repair
成纤维细胞靶向心肌修复
  • 批准号:
    10636106
  • 财政年份:
    2023
  • 资助金额:
    $ 50.66万
  • 项目类别:
Myocardial Plasticity in Heart Failure with Preserved Ejection Fraction (HFpEF)
射血分数保留的心力衰竭 (HFpEF) 中的心肌可塑性
  • 批准号:
    10367549
  • 财政年份:
    2022
  • 资助金额:
    $ 50.66万
  • 项目类别:
Myocardial Plasticity in Heart Failure with Preserved Ejection Fraction (HFpEF)
射血分数保留的心力衰竭 (HFpEF) 中的心肌可塑性
  • 批准号:
    10661497
  • 财政年份:
    2022
  • 资助金额:
    $ 50.66万
  • 项目类别:
Therapeutic Targeting of Tissue Inhibitor-4 in Hypertrophy and Failure
组织抑制剂 4 在肥大和衰竭中的治疗靶向
  • 批准号:
    9346782
  • 财政年份:
    2016
  • 资助金额:
    $ 50.66万
  • 项目类别:
Therapeutic targeting of tissue inhibitor-4 in hypertrophy and failure
组织抑制剂 4 在肥大和衰竭中的治疗靶向
  • 批准号:
    9751943
  • 财政年份:
    2016
  • 资助金额:
    $ 50.66万
  • 项目类别:
Therapeutic targeting of tissue inhibitor-4 in hypertrophy and failure
组织抑制剂 4 在肥大和衰竭中的治疗靶向
  • 批准号:
    9174201
  • 财政年份:
    2016
  • 资助金额:
    $ 50.66万
  • 项目类别:
Proteolytic Imaging of Remodeling Myocardium
心肌重塑的蛋白水解成像
  • 批准号:
    9138519
  • 财政年份:
    2016
  • 资助金额:
    $ 50.66万
  • 项目类别:
Reversal of Myocardial Infarction by Localized Stimulation
通过局部刺激逆转心肌梗塞
  • 批准号:
    8591918
  • 财政年份:
    2013
  • 资助金额:
    $ 50.66万
  • 项目类别:
Myocardial Protection and Matrix Proteases
心肌保护和基质蛋白酶
  • 批准号:
    8653132
  • 财政年份:
    2010
  • 资助金额:
    $ 50.66万
  • 项目类别:
Continuous monitoring of anti-fibrinolytic therapy in cardiovascular surgery
心血管手术中抗纤溶治疗的持续监测
  • 批准号:
    8213199
  • 财政年份:
    2010
  • 资助金额:
    $ 50.66万
  • 项目类别:

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