2014 Drug Carriers in Medicine and Biology Gordon Research Conference and Gordon

描述(由申请者提供)：申请资助将于2014年8月16日至22日在新罕布夏州沃特维尔山谷度假村举行的戈登研究会议和相关的戈登研究研讨会关于药物载体在医学和生物学上的应用。这次综合性会议将聚焦于药物输送方面的前沿研究，同时为来自学术界和工业界的初级和高级研究人员、学生和博士后提供一个相互接触的杰出论坛。长期目标是促进合作，将该领域提升到一个更高的水平，支持年轻研究人员的成长和发展，以增加这一重要主题的工作人员渠道，并为将尖端研究转化为临床和患者提供一条途径。药物传递是现代医学的重要组成部分，靶向药物载体的设计和优化是一个重要的研究领域。GRC的副主题是“利用机制和化学设计改善治疗效果”，GRS是“分子和细胞”。特别是，会议将侧重于最新的交付系统，并包括关于运营商分配机制、蜂窝吸收和贩运以及解决障碍的新方法的会议。会议主题包括靶向给药系统，化学修饰的新方法，工程学，改善给药的偶联，以及药物给药系统的运输、命运和疗效。在眼科递送、癌症和免疫治疗方面的应用和令人兴奋的机会将包括在特定的会议中。临床机会和翻译将是会议的关键焦点，业界参与将提供这一观点。演讲者和讨论领导者是各自领域公认的领导者，他们是在与代表药物输送领域广度的科学家协商后选出的。GRC/GRS方案反映了人口在性别、职业阶段、地点和代表性不足的少数群体方面的多样性。特别是，这一高质量的节目将 包括来自职业生涯早期阶段的演讲(GRS的研究生和博士后，GRC的助理和副教授以及年轻的工业研究人员)，来自代表性不足群体的人，以及女性。将通过积极招聘和登记来自代表性不足群体的教员和受训人员，进一步促进多样性。这项提案专门为这一目标寻求资金。药物靶向GRC/GRS工程进展的具体目标是：1)提供一个讨论最新药物载体研究的论坛。2)将在不同药物输送设计领域工作的不同科学家小组聚集在一起。3)通过确定知识差距和改进概念模型，确定未来几年的优先研究主题。4)为学员和高级研究人员之间的互动提供一个高质量和可接近的场所。5)为青年研究人员提供演讲和海报的渠道，并为他们未来的职业生涯拓宽培训范围。

DESCRIPTION (provided by applicant): Funding is requested for partial support of the Gordon Research Conference and associated Gordon Research Symposium on Drug Carriers in Medicine and Biology to be held in Waterville Valley Resort, New Hampshire August 16-22, 2014. This comprehensive meeting will focus on cutting edge research in drug delivery, while simultaneously providing an outstanding forum for junior and senior researchers, students and postdocs from academia and industry to engage each other. The long term goals are to foster collaboration to bring the field to an even higher level, support the growth and development of young researchers in order to increase the worker pipeline in this important topic, and to provide an avenue for translation of cutting edge research to the clinic and patients. Drug delivery is a crucial component of modern day medicine, and the design and optimization of targeted drug carriers is an important area of research. The subtopic of the GRC is "Leveraging Mechanism and Chemical Design for Improved Therapeutic Effect" and the GRS is " Molecular and Cellular." In particular, the conference will focus on the latest delivery systems and include sessions on mechanisms of carrier distribution, cellular uptake and trafficking, and new approaches to addressing hurdles. Session themes include targeted systems for delivery, new approaches to chemical modification, engineering, and conjugation for improved delivery, and transport, fate, and efficacy of drug delivery systems. Applications and exciting opportunities in ophthalmic delivery, cancer, and immunotherapy will be included in specific sessions. Clinical opportunities and translation will be a key focus of the meeting, with industrial participation to give this perspective. Speakers and discussion leaders are recognized leaders in their fields and were chosen in consultation with scientists who represent the breadth of the field of drug delivery. The GRC/GRS program reflects diversity in the population in terms of gender, career stage, location, and underrepresented minority group. In particular, this high quality program will include talks from early career stages (graduate students and postdocs for the GRS and assistant and associate professors and young industrial researchers for the GRC), from persons of underrepresented groups, and females. Diversity will be further boosted through active recruitment and registration of faculty and trainees from underrepresented groups. This proposal seeks funding specifically for this goal. The specific objectives of the Engineering Advances in Drug Targeting GRC/GRS are: 1) To provide a forum for discussion of the latest drug carrier research. 2) To bring together a diverse group of scientists working in different areas of drug delivery design. 3) To identify priority research themes for the coming years by identifying gaps in knowledge and improving conceptual models. 4) To provide a high quality and accessible arena for interaction between trainees and senior researchers. 5) To provide an avenue for young researchers to give talks and posters and to broaden their training for their future careers.