Morehouse Sch of Medicine/Tuskegee Univ/University of Alabama Ca Ctr Partnership

莫尔豪斯医学院/塔斯基吉大学/阿拉巴马大学 CA Ctr 合作伙伴关系

• 批准号: 8734243
• 负责人: Daniel S. Blumenthal
• 金额: $ 105.85万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8734243
• 关键词: Achievement; Address; Advocacy; African American; Alabama; Area; Award; Basic Science; Bioethics; Biometry; Cancer Biology; Cancer Control; Cancer Research Project; Cancer Survivor; Clinical; Clinical Trials; Colon Carcinoma; Commit; Communities; Community Health; Development; Diet; Discipline; Education; Educational Curriculum; Educational process of instructing; Enrollment; Ensure; Epidemiology; Evaluation; Extramural Activities; Faculty; Foundations; Funding; Goals; Growth; Institution; Intervention; Lead; Life Style; Link; Malignant Neoplasms; Manuscripts; Medical; Medicine; Minority; Mission; Modeling; NCI-Designated Cancer Center; Organizational Change; Outcome; Participant; Peer Review; Physical activity; Pilot Projects; Policies; Population Sciences; Procedures; Productivity; Public Health; Publications; Publishing; Recruitment Activity; Research; Research Institute; Research Personnel; Research Training; Resource Sharing; Resources; Rural; Scientist; Secure; Students; Therapy Clinical Trials; Time; Training; Training Programs; Training and Education; Underserved Population; Universities; anticancer research; base; cancer education; cancer health disparity; career; career development; graduate student; health disparity; improved; interest; investigator training; member; men who have sex with men; outreach; outreach program; programs; prospective; screening; success; undergraduate student

The overall objective of the MSM/TU/UAB CCC Partnership is to reduce and eliminate cancer health disparities. This is being achieved through our programs of Cancer Research, Cancer Training, Cancer Education, Cancer Outreach, Bioethics, and Biostatistics, which are leading to sustained, integrated, organizational changes at the three Institutions. Significant milestones have been reached. At MSM, a Cancer Research Program (CRP) was established In 2007 by developing an organizational framework for the previously disconnected cancer research scientists and teams. The program consists of four sections, Basic Science Research, Community and Epidemiological Research, Clinical Trials Exploratory, and Research Training and Career Development. Thirty faculty members from diverse scientific disciplines are associated with the CRP. In parallel, TU has demonstrated increased capacity to conduct research on cancerhealth disparities by training and garnering a critical mass of scientists who focus on reducing and eliminating these disparities. In 2005, 7 scientists at TU were involved in some aspect of cancer research, compared to 17 in 2010. With the central teaching mission of Tuskegee, the training of 9 undergraduates and 22 graduate students in cancer research since 2005 demonstrates TU's ability to establish a pipeline of prospective minority investigators who are focusing on cancer research. This growth in health disparity research and education led to the creation, in December 2010, of the Health Disparities Institute for Research and Education (HDIRE) at TU. Dr. Roberta Troy, Co-PI on the U54 Partnership, was appointed as its founding director. The HDIRE has as its mission the elimination and/or mitigation of health disparities through research, education, and training, and through advocacy of policies relevant to underserved populations, particularly in the Black Belt region of Alabama. The UAB CCC has similarly expanded its capacity to conduct cancer health disparities research. In the past 5 years, UAB has recruited 6 new faculty members involved in such research. Each of the institutions has had increases in cancer research funding, indicating scientific productivity. At MSM, S8M was secured in 2000 to support cancer research. By 2005, cancer research funding increased to $18M, and, by 2010, to $26M. Similarly, cancer research funding increased at TU, exceeding $6M in 2010. At the UAB CCC, there was an increase in annual funding from $12M in 2005 to $22M by 2010 in its Cancer Control and Population Sciences Program. This increase was mostly related to research on cancer disparities. While the evaluation of each of the cores and programs is detailed in the respective sections, it is appropriate to highlight some of the achievements. The Developmental Research Proaram continues to be strengthened and to produce competitive and productive investigators. Since its inception, 10 pilot projects and 1 full project have been awarded, and all but one pilot have been or are being successfully conducted. As of December 2010, 17 peer-reviewed publications directly related to the goals of U54 have been generated, a remarkable increase from 1 publication in 2008. Additionally, investigators of this Partnership have published 75 peer-reviewed manuscripts that are directly related to cancer disparities (see Appendix A-C). Over the past 5 years, the Cancer Training Program has trained 81 scholars (28 junior faculty and 53 graduate students) to perform cancer-related research. While 61% of the scholars have extramural funding, 21% have secured additional extramural funding since completing the program.), and 43% of them have published manuscripts. The Cancer Education Program, which is essential for ensuring a pipeline of well-trained students who elect to pursue research in cancer health disparities and related professions, has developed a cancer-related course (Foundations of Cancer Biology) that has been incorporated and sustained as part of the TU curriculum. Recently, Cancer Education Co-Leaders and Bioethics Shared Resource members of the Partnership have developed and offered a Health Disparities, Bioethics, and Policy course at TU. The Cancer Outreach Programs, based on the community health advisor model, have achieved their medium-term outcomes. Through a relationship with the Department of Public Health, the MSM program disseminated an intervention for colon cancer screening in the greater Atlanta area. UAB's Cancer Outreach Program increased participation of African Americans in cancer therapeutic trials, with 180 referrals to the program and 124 cancer survivors enrolling in their IMPACT program. At TU, outreach efforts led to a program addressing healthy lifestyles among rural residents, with participants increasing physical activity and making improved dietary choices. Bioethics activities continue to be highly rated within the Partnership and by other collaborators. As essential resources, Biostatistics and Bioethics are integrated throughout the Partnership. In summary, consistent with the outcomes outlined in our Evaluation Framework developed for the previous application, our tripartite Partnership has achieved short and medium-term outcomes and is now realizing long-term outcomes, including integrated, organizational changes at each of the institutions. These will lead to high-quality research on cancer health disparities, produce well-trained investigators, and reduce cancer disparities.

MSM/TU/UAB CCC伙伴关系的总体目标是减少和消除癌症健康差距。这是通过我们的癌症研究、癌症培训、癌症教育、癌症外展、生物伦理学和生物统计学计划实现的，这些计划正在导致这三个机构的持续、综合和组织变革。已经达到了重要的里程碑。 在MSM，2007年建立了一个癌症研究计划(CRP)，为以前相互脱节的癌症研究科学家和团队制定了一个组织框架。该计划由基础科学研究、社区和流行病学研究、临床试验探索性和 研究、培训和职业发展。来自不同科学学科的30名教职员工与CRP联系在一起。与此同时，TU通过培训和招募一大批专注于减少和消除癌症的科学家，证明了开展癌症健康差距研究的能力有所增强 这些差异。2005年，TU有7名科学家参与了某些方面的癌症研究，而2010年只有17名。在塔斯基吉大学的中心教学使命下，自2005年以来，对9名本科生和22名研究生进行了癌症研究方面的培训，证明了塔斯基吉大学有能力建立一条面向少数族裔的渠道 专注于癌症研究的研究人员。健康差距研究和教育的这种增长导致了 2010年12月，在理工大成立了健康差距研究和教育研究所。U54伙伴关系的共同PI罗伯塔·特洛伊博士被任命为其创始主任。HDIRE的使命是通过研究、教育和培训消除和/或缓解健康差距， 并通过宣传与未得到充分服务的人口有关的政策，特别是在阿拉巴马州的黑带地区。UAB CCC也同样扩大了其进行癌症健康差异研究的能力。在过去的5年里，UAB招聘了6名参与此类研究的新教职员工。 每一家机构的癌症研究资金都有所增加，这表明了科学生产率。在MSM，S8M于2000年获得支持，以支持癌症研究。到2005年，癌症研究经费增加到1800万美元，到2010年增加到2600万美元。同样，德克萨斯大学的癌症研究经费也有所增加，2010年超过600万美元。在… 在UAB CCC，其癌症控制和人口科学项目的年度资金从2005年的1200万美元增加到2010年的2200万美元。这一增长主要与癌症差异的研究有关。 虽然各节详细介绍了对每项核心和方案的评价，但应着重说明其中的一些成就。发展研究方案继续得到加强，并产生有竞争力和多产的调查人员。自成立以来，已授予10个试点项目和1个完整项目，除1个试点项目外，所有试点项目都已或正在成功进行。截至2010年12月，产生了17份与U54目标直接相关的同行评议出版物，比2008年的1份大幅增加。此外，该伙伴关系的调查人员发表了75篇与癌症差异直接相关的同行评议手稿(见附录A-C)。在过去的5年里，癌症培训计划已经培训了81名学者(28名初级教员和53名研究生)进行癌症相关研究。虽然61%的学者有外部资金，21%的人在完成项目后获得了额外的外部资金。)，其中43%的人出版了手稿。 癌症教育计划对于确保选择从事癌症健康差距和相关职业研究的训练有素的学生的渠道至关重要，该计划开发了一门与癌症相关的课程(癌症生物学基础)，该课程已被纳入并维持为TU课程的一部分。 最近，癌症教育联合领导者和该伙伴关系的生物伦理共享资源成员在TU开发并提供了一门健康差异、生物伦理和政策课程。 以社区健康顾问模式为基础的癌症外展计划已经取得了中期成果。通过与公共卫生部的关系，男男性接触者计划在大亚特兰大地区传播结肠癌筛查的干预措施。UAB的癌症外展计划增加了非裔美国人参与癌症治疗试验，有180人转诊到 计划和124名癌症幸存者登记参加他们的IMPACT计划。在TU，外展努力导致了一个解决农村居民健康生活方式的计划，参与者增加了身体活动，并做出了改善的饮食选择。生物伦理活动在伙伴关系内和其他合作者中继续受到高度评价。作为基本资源，生物统计学和生物伦理学在整个伙伴关系中得到整合。 总之，根据我们为前一次应用制定的评价框架中概述的结果，我们的三方伙伴关系已经取得了短期和中期成果，现在正在实现长期成果，包括每个机构的综合组织变革。这些将导致对癌症健康差异的高质量研究，产生训练有素的调查人员，并减少癌症差异。